Paul Calabresis Award in Clinical Oncology Research

描述（由申请人提供）：科罗拉多大学NCI综合癌症中心（UCCC） K12项目的目标是培养成功的以患者为导向的临床和基础研究研究者，他们可以在转化的团队研究环境中有效地相互合作。这些研究人员将能够独立设计、实施和管理临床试验研究的各个阶段，重点是将实验室发现转化为临床应用，以及促进实验室研究进入尚不清楚的临床现象的基本机制。具体目标是：1)为完成临床培训并致力于在学术环境中从事转化临床癌症研究的肿瘤医学博士和博士护士以及致力于以患者为导向研究的基础科学家提供灵活的职业发展计划；2)通过对项目学者的多次指导，促进跨学科的培训、交流和互动；3)在这些初级教师学者的正式职业发展计划结束后，为他们提供持续指导的机会，以确保他们成功过渡到临床研究的独立性。所有肿瘤学学科和基础研究人员的临床和科学导师将合作培训这些学者。一个多学科咨询委员会将与项目负责人一起监督该项目。整个培训期将持续2至7年，包括教学、对学科领域医学文献的批判性评估、临床经验、基于科学的临床研究培训和临床医生的基本研究经验。K30奖将提供教学课程，支持临床科学家培训计划，通过系列讲座、研讨会、期刊俱乐部、讲习班、参加国家会议和学者展示研究成果的机会来加强。通过各种培训经验，强调负责任的研究行为。每位学者必须在培训的最后一年内提交一份NIH风格资助申请。在UCCC的第一个五年奖励期间，五个肿瘤学学科的六名医学博士学者接受了培训。五人仍沉浸在临床转化为人类导向的研究中，四人是UCDHSC的教员，其中三人已经晋升。生产力包括70篇论文，23篇第一作者或高级作者，多篇摘要报告，50项临床试验作为PI或共同PI发起，13项拨款奖励，其中6项由主要赞助商提供。因此，K12项目已经非常成功地达到了培养以人为本的肿瘤研究人员的最终目标，这些研究人员成功地、独立地进行了扎实和创新的临床肿瘤研究。

DESCRIPTION (provided by applicant): The goal of the University of Colorado NCI Comprehensive Cancer Center (UCCC) K12 program is to train successful patient-oriented clinical and basic research investigators who can work effectively with each other in a translational, team research setting. These researchers will be able to independently design, implement and manage all phases of clinical trials research with an emphasis on translation of laboratory findings into clinical applications, as well as facilitating laboratory studies into the basic mechanisms of poorly understood clinical phenomena. The specific objectives are to: 1) Provide a flexible career development program for oncology medical doctors and Ph.D. nurses who have completed their clinical training and who are committed to a translational clinical cancer research career in an academic setting, as well as basic scientists committed to patient-oriented research; 2) Foster interdisciplinary training, communication and interaction through multiple mentoring of program scholars; 3) Create an opportunity of ongoing mentorship to support these junior faculty scholars after their formal career development program ends to ensure their successful transition to clinical research independence. Strong clinical and scientific mentors in all oncology disciplines and basic researchers will collaborate to train the Scholars. A multidisciplinary Advisory Committee will oversee the program together with Program Leader. Madeleine A. Kane, MD, Ph.D. The overall training period will last from two to seven years and will include didactics, critical evaluation of the medical literature in the subject area, clinical experience, scientifically-based clinical research training and a basic research experience for clinicians. Didactic coursework will be provided from the K30 Award supporting the Clinical Scientist Training Program enhanced by lecture series, seminars, journal clubs, workshops, attendance at national meetings and opportunities for scholars to present research results. Responsible conduct of research will be emphasized through various training experiences. Each scholar is required to submit an NIH style grant application within the last year of training. Six MD Scholars in five oncology disciplines received training during the first five-year award to UCCC. Five remain immersed in clinical-translational human-oriented research, four as UCDHSC faculty, three of whom have been promoted. Productivity includes 70 papers, 23 as first or senior author, multiple abstract presentations, 50 clinical trials initiated as PI or co-Pi, and 13 grant awards, 6 of which were by major sponsors. This K12 program has thus been highly successful in reaching the ultimate goal of producing human-oriented oncology research investigators who successfully and independently conduct solid and innovative clinical oncology research.