Paul Calabresis Award in Clinical Oncology Research

临床肿瘤学研究保罗·卡拉布雷西斯奖

• 批准号: 7470970
• 负责人: MADELEINE A. KANE
• 金额: $ 60.48万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-18 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470970
• 关键词: Adult; Advisory Committees; Applications Grants; Area; Arts; Award; Basic Behavioral Science; Basic Science; Behavioral Research; Cancer Center; Cancer Patient; Caring; Childhood; Clinical; Clinical Oncology; Clinical Protocols; Clinical Research; Clinical Trials; Clinical and Translational Science Awards; Colorado; Commit; Communication; Community Clinical Oncology Program; Comprehensive Cancer Center; Development; Discipline; Doctor of Philosophy; Educational workshop; Ensure; Environment; Evaluation; Faculty; Fostering; Goals; Grant; Health Sciences; Hospitals; Human; Institutes; Investigation; Journals; Laboratory Finding; Laboratory Study; Literature; Malignant Neoplasms; Medical; Medical Oncology; Mentored Clinical Scientist Development Program; Mentors; Mentorship; NCI Scholars Program; Nurses; Paper; Pediatric Hospitals; Phase; Populations at Risk; Productivity; Program Development; Purpose; Qualifying; Research; Research Activity; Research Infrastructure; Research Peer Review; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Series; Solid; Stress; Testing; Therapeutic; Therapeutic Human Experimentation; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; Work; abstracting; anticancer research; base; career; clinical application; design; experience; improved; innovation; lectures; multidisciplinary; oncology; patient oriented; patient oriented research; prevent; programs; research facility; success

DESCRIPTION (provided by applicant): The goal of the University of Colorado NCI Comprehensive Cancer Center (UCCC) K12 program is to train successful patient-oriented clinical and basic research investigators who can work effectively with each other in a translational, team research setting. These researchers will be able to independently design, implement and manage all phases of clinical trials research with an emphasis on translation of laboratory findings into clinical applications, as well as facilitating laboratory studies into the basic mechanisms of poorly understood clinical phenomena. The specific objectives are to: 1) Provide a flexible career development program for oncology medical doctors and Ph.D. nurses who have completed their clinical training and who are committed to a translational clinical cancer research career in an academic setting, as well as basic scientists committed to patient-oriented research; 2) Foster interdisciplinary training, communication and interaction through multiple mentoring of program scholars; 3) Create an opportunity of ongoing mentorship to support these junior faculty scholars after their formal career development program ends to ensure their successful transition to clinical research independence. Strong clinical and scientific mentors in all oncology disciplines and basic researchers will collaborate to train the Scholars. A multidisciplinary Advisory Committee will oversee the program together with Program Leader. Madeleine A. Kane, MD, Ph.D. The overall training period will last from two to seven years and will include didactics, critical evaluation of the medical literature in the subject area, clinical experience, scientifically-based clinical research training and a basic research experience for clinicians. Didactic coursework will be provided from the K30 Award supporting the Clinical Scientist Training Program enhanced by lecture series, seminars, journal clubs, workshops, attendance at national meetings and opportunities for scholars to present research results. Responsible conduct of research will be emphasized through various training experiences. Each scholar is required to submit an NIH style grant application within the last year of training. Six MD Scholars in five oncology disciplines received training during the first five-year award to UCCC. Five remain immersed in clinical-translational human-oriented research, four as UCDHSC faculty, three of whom have been promoted. Productivity includes 70 papers, 23 as first or senior author, multiple abstract presentations, 50 clinical trials initiated as PI or co-Pi, and 13 grant awards, 6 of which were by major sponsors. This K12 program has thus been highly successful in reaching the ultimate goal of producing human-oriented oncology research investigators who successfully and independently conduct solid and innovative clinical oncology research.

描述(由申请人提供)：科罗拉多大学NCI综合癌症中心(UCCC)K12项目的目标是培养成功的以患者为导向的临床和基础研究研究员，他们能够在翻译的团队研究环境中相互有效合作。这些研究人员将能够独立设计、实施和管理临床试验研究的所有阶段，重点是将实验室结果转化为临床应用，以及促进对鲜为人知的临床现象的基本机制的实验室研究。具体目标是：1)为已完成临床培训并致力于在学术环境中从事转化性临床癌症研究职业生涯的肿瘤学医生和博士护士以及致力于以患者为中心的研究的基础科学家提供灵活的职业发展计划；2)通过对计划学者的多重指导，促进跨学科培训、交流和互动；3)创造持续指导的机会，在这些初级教师学者的正式职业发展计划结束后为他们提供支持，以确保他们成功过渡到临床研究独立。所有肿瘤学学科的强大临床和科学导师和基础研究人员将合作培训学者。一个多学科咨询委员会将与项目负责人一起监督该项目。整个培训期将从两年到七年，包括教学、对学科领域医学文献的批判性评估、临床经验、以科学为基础的临床研究培训和临床医生的基础研究经验。教学课程将从K30奖中提供，以支持临床科学家培训计划，通过系列讲座、研讨会、期刊俱乐部、研讨会、出席全国会议和为学者提供展示研究成果的机会来加强。将通过各种培训经验强调负责任的研究行为。每位奖学金获得者必须在接受培训的最后一年内提交一份NIH风格的拨款申请。在UCCC的第一个五年奖期间，五个肿瘤学学科的六名MD学者接受了培训。五人仍然沉浸在临床翻译的以人为本的研究中，四人是UCDHSC的教员，其中三人已经晋升。生产力包括70篇论文，23篇第一作者或资深作者，多篇摘要报告，50项临床试验作为PI或联合PI发起，13个授予奖，其中6个由主要赞助商颁发。因此，K12项目非常成功地实现了最终目标，即培养以人为本的肿瘤学研究人员，他们成功并独立地进行扎实和创新的临床肿瘤学研究。