Maximum Drinks, Alcoholism and Psychopathology Risk

最大饮酒量、酗酒和精神病理学风险

• 批准号: 7493492
• 负责人: STEPHEN MATTHEW MALONE
• 金额: $ 7.54万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493492
• 关键词: Address; Adolescence; Adolescent; Age; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Arts; Award; Behavior; Behavioral Genetics; Belief; Brain; Candidate Disease Gene; Characteristics; Child; Classification; Cognitive; Complex; Conflict (Psychology); Consumption; Data; Data Analyses; Development; Diagnosis; Diagnostic and Statistical Manual; Disease; Environmental Risk Factor; Epidemiology, Other; Etiology; Event-Related Potentials; Freedom; Funding; Genetic; Genetic Risk; Goals; Image Analysis; Individual; Intervention; Investigation; K-Series Research Career Programs; Light; Magnetic Resonance Imaging; Measures; Mediating; Methods; Minor; Neurosciences; Numbers; Outcome; Parent-Child Relations; Parents; Pathway interactions; Personal Satisfaction; Personality; Phenotype; Prevention intervention; Problem behavior; Process; Psychiatric Diagnosis; Psychopathology; Qualifying; Research; Research Personnel; Resolution; Risk; Risk Factors; Role; Sampling; Statistical Methods; Structure; Substance abuse problem; Time; Training; Training Activity; alcohol related problem; alcohol research; base; consumption measures; developmental psychology; drinking; genetic epidemiology; genetic risk factor; improved; neuromechanism; novel; peer; problem drinker; relating to nervous system; sex; tool

DESCRIPTION (provided by applicant): The overarching goals of this proposal are twofold: 1) to develop a programmatic line of research aimed at shedding light on the development of alcohol-related problems in adolescence and into adulthood using an intermediate phenotype maximum 24-hr alcohol consumption that has shown considerable promise as an indicator of risk in preliminary studies; and 2) to augment the applicant's training in developmental psychology with additional training in psychopathology, statistical methods for longitudinal data analysis, neuroscience, genetics (behavioral genetics, genetic epidemiology, and other quantitative methods), and advanced methods of event-related potential and magnetic resonance imaging analysis of brain structure and dynamics. The proposed research plan will build on findings that maximum consumption appears to relate more directly to the mechanisms conferring risk for SUDs than a psychiatric diagnosis of alcohol dependence and will use a developmentally and genetically-informed, multimethod approach to 1) evaluate the construct validity of the maximum consumption phenotype, 2) describe developmental trajectories among adolescent youth in relation to substance abuse risk and 3) to characterize neural dynamics among high-risk adolescents. The training activities will better prepare the applicant to conduct the proposed research, and the award would provide the freedom to pursue systematic research on this important phenotype. Together these will allow the applicant to pursue his ultimate goal as an independent researcher investigating neural processes associated with externalizing disorders and substance abuse. In addition, this research is likely to yield theoretically and clinically useful findings. It will extend previous research on electrophysiological correlates of substance abuse risk and ultimately holds significant promise for intervention efforts with high-risk individuals.

描述（由申请人提供）：该提案的总体目标有两个：1）开发一项计划性研究，旨在利用中间表型最大 24 小时饮酒量来揭示青春期和成年期酒精相关问题的发展，该中间表型在初步研究中已显示出作为风险指标的巨大前景； 2）通过精神病理学、纵向数据分析统计方法、神经科学、遗传学（行为遗传学、遗传流行病学和其他定量方法）以及事件相关电位和大脑结构和动力学的磁共振成像分析的高级方法来增强申请人的发展心理学培训。拟议的研究计划将建立在以下发现的基础上：与酒精依赖的精神病学诊断相比，最大消费似乎与赋予 SUD 风险的机制更直接相关，并将使用发育和遗传信息的多方法方法来 1）评估最大消费表型的结构有效性，2）描述青少年中与药物滥用风险相关的发展轨迹，3）描述高风险人群中的神经动力学特征 青少年。培训活动将使申请人更好地准备进行拟议的研究，并且该奖项将提供对这一重要表型进行系统研究的自由。这些将使申请人能够作为一名独立研究人员追求他的最终目标，研究与外在疾病和药物滥用相关的神经过程。此外，这项研究可能会产生理论上和临床上有用的发现。它将扩展之前关于药物滥用风险的电生理学相关性的研究，并最终为高风险个体的干预工作带来重大希望。