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BMC--BHASIN

基本信息

批准号：
7422165
负责人：
SHALENDER BHASIN
金额：
$ 67.15万
依托单位：
BOSTON MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7422165
关键词：
Age Aging American Biological Markers Biological Models Biology Boston Caloric Restriction Centenarian Clinic Clinical Clinical Research Collaborations Communities Community Outreach Computer Assisted Core Facility Dependence Development Discipline Education Elderly Endocrinology Epidemiologic Studies Epidemiology Event Exercise Exercise Physiology Fostering Fracture Framingham Heart Study Funding Generations Geriatrics Grooming Health Services Human Individual Interdisciplinary Study Intervention Trial Investigation K-Series Research Career Programs Leadership Life Link Massachusetts Medical center Mentors Methods Modality Molecular Genetics Monitor Muscle New England Newsletter Nutritional Outcome Outcome Assessment Outcome Measure Physical Function Physical activity Pilot Projects Positioning Attribute Prevention Process Program Development Quality of life Range Recording of previous events Recruitment Activity Research Research Activity Research Infrastructure Research Personnel Research Training Resources Risk Scientist Signal Transduction Stem cells Structure Systems Biology Technology Testosterone Training Training Programs Translational Research Translations Universities Validation age related base bench to bedside career cohort concept cost disability drug discovery efficacy trial experience falls functional decline improved innovation instrument interdisciplinary approach interdisciplinary collaboration male member method development mortality next generation novel nutrition older men pre-clinical programs tool

项目摘要

Boston Medical Center, Boston, Massachusetts (BMC) Bhasin, Shalender Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers.

波士顿医疗中心，波士顿，马萨诸塞州（BMC）