Cell Culture and Molecular Technology Core

SDRC细胞培养和分子技术核心（CCMTC）在促进 皮肤为基础的研究活动在医学的案例学校在其十五年的历史。在此 在此期间，该中心提供了基本服务和培训，以及最先进的服务、设施和 专业知识CCMTC现已发展成为校园研究活动的主要中心，并拥有 在引入新的研究人员从事皮肤病研究方面发挥积极作用。核心正在全力投入 为研究者提供广泛的培养皮肤细胞，并提供细胞培养培训， 方法学和分子生物学技术。CCMTC的三大使命包括： 以下.具体目标I CCMTC的主要目标是提供最先进的细胞培养和 分子技术服务和专业知识，并节省成本，皮肤病研究中心 （SDRC）成员在凯斯西储大学医学院，并以更大的 凯斯医学院附属的研究人员社区。CCMTC一直非常 成功地为调查人员提供了新技术。这仍然是该委员会的核心目标。在 为了应对不断变化的科学环境的需求，核心在历史上增加了新的国家， 艺术技术，因为它变得可用。除了目前正在开发的大量技术之外， 提供，我们现在将提供先进的实时荧光成像，专业知识和培训， 细胞内蛋白质-蛋白质相互作用的可视化（FRET、FRAP等），芯片阵列分析，以及 蛋白质组学具体目标2 CCMTC的一个主要目标，与其他SDRC核心一起，是 提供细胞和分子技术，以及专业知识，促进和鼓励基本的翻译 把科学项目带到床边SDRC的一个主要目标是作为一个渠道， 皮肤科治疗，将新的诊断和治疗带到床边，目的是改善 病人护理具体目标3：职业培训中心的第三个目标是促进职业发展， 留住有才华的年轻博士和医学博士皮肤科科学的研究人员。这是通过 向新调查员和高级调查员提供有助于调查的技术培训 提供一个讨论皮肤病科学的论坛。

The SDRC Cell Culture and Molecular Technology Core (CCMTC) has played an important role in facilitating skin-based research activity at the Case School of Medicine throughout its fifteen year history. During this time, the core has provided basic services and training, and also state-of-the-art services, facilities and expertise. The CCMTC has now developed into a major hub of research activity on campus and has an active role in introducing new investigators to work on dermatological disease. The core is heavily engaged in providing a wide range of cultured skin cells to investigators, and in providing training in cell culture methodology and molecular biology technology. The three major missions of the CCMTC include the following. Specific Aim I A primary goal of the CCMTC is to provide state-of-the-art cell culture and molecular technology services and expertise, and cost savings to the Skin Diseases Research Center (SDRC) membership at the Case Western Reserve University School of Medicine, and to the larger community of researchers affiliated with the Case School of Medicine. The CCMTC has been very successful in supplying investigators with new technology. This remains a core goal of the CCMTC. In response to the demands of a changing scientific environment, the core has historically added new state-ofthe- art technology as it becomes available. In addition to the substantial list of technology that is presently offered, we will now provide access, expertise and training in advanced real-time fluorescent imaging for visualization of intracellular protein-protein interaction (FRET, FRAP, etc.), chip array analysis, and proteomics. Specific Aim 2 A major goal of the CCMTC, in conjunction with the other SDRC cores, is to provide cell and molecular technology, and expertise, that facilitates and encourages the translation of basic science projects to the bedside. A major goal of the SDRC is to serve as a conduit that benefits dermatologic therapy by bringing new diagnoistics and treatments to the bedside with the goal of improving patient care. Specific Aim 3 The third goal of the CCMTC is to promote career development with a goal of retaining talented young Ph.D. and M.D. investigators in the dermatologic sciences. This is achieved by providing training to new investigators and senior investigators in technologies that will facilitate investigation of dermatologic diseases and by providing a forum for discussion of dematologic science.