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Core--Non-Human Primate Facility

核心——非人类灵长类动物设施

基本信息

批准号：
7650393
负责人：
ANDREW A LACKNER
金额：
$ 35.89万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7650393
关键词：
AIDS neuropathy Acquired Immunodeficiency Syndrome Animal Experimentation Animals Autopsy Biopsy Blood Body Fluids Bronchoalveolar Lavage Caring Centers of Research Excellence Cerebrospinal Fluid Clinical Clinical Chemistry Clinical Management Collaborations Collection Confocal Microscopy Daily Development Dimensions Disease Ensure Experimental Designs Faculty Feces Flow Cytometry Funding Goals Health Sciences Hematology Housing Human Image Analysis Immunohistochemistry Immunology In Situ Hybridization Individual Infectious Diseases Research Institution Investigation Laboratories Liquid substance Louisiana Macaca Macaca mulatta Microbiology Mission Modeling Operative Surgical Procedures Ovum Parasites Pathogenesis Pathologic Pathology Philadelphia Pilot Projects Primates Procedures Production Publishing Purpose Research Research Personnel Resources SIV Saliva Scientist Services Strategic Planning Time Translations Universities Viral Visit Work animal care base concept expectation experience interdisciplinary approach member microbicide molecular pathology nonhuman primate programs simian human immunodeficiency virus success therapeutic vaccine transmission process

项目摘要

The objective of the Non-Human Primate Core is to provide highly integrated clinical management and laboratory investigations using non-human primate models of AIDS to CFAR investigators. The Core will enhance and facilitate the ability of CFAR investigators to perform studies in non-human primates and promote scientific collaborations between the TNPRC and CFAR colleagues in Philadelphia. The Core consists of clinical and laboratory components. The clinical component will acquire, house and care for the non-human primates and assist investigators with experimental design. The Core will also be responsible for the daily clinical care of animals and animal procedures such as immunizing the animals, blood draws, fluid collection, bronchoalveolar lavage, biopsies, etc. The laboratory component of the Core will perform routine hematology, clinical chemistry, ova and parasite examination of feces, microbiology, and pathologic examination of all necropsies and biopsies in support of the animal studies. The Core will also provide flow cytometry and immunology services, SIV and SHIV viral stocks and isolation, and specialized pathology services including in situ hybridization, immunohistochemistry, confocal microscopy and image analysis. The Core also includes animals and animal support for developmental studies. It is our expectation that the combination of non-human primate resources and specialized research expertise with non-human primate models of AIDS will enhance the AIDS research mission of the CFAR and result in new and stronger collaborations as well as attracting new investigators to use non-human primate models of AIDS.

非人灵长类核心的目标是提供高度集成的临床管理以及使用非人类灵长类动物艾滋病模型进行的实验室研究。核心将提高和促进CFAR研究人员在非人类灵长类动物中进行研究的能力，并促进TNPRC和费城CFAR同事之间的科学合作。核心由临床和实验室组成。临床部分将获得、安置和照顾非人灵长类动物，并协助研究人员进行实验设计。核心还将负责动物的日常临床护理和动物程序，如动物免疫接种、抽血、液体收集、支气管肺泡灌洗、活检等。核心的实验室部分将进行常规血液学、临床化学、粪便的虫卵和寄生虫检查、微生物学以及所有尸检和活检的病理学检查，以支持动物研究。该中心还将提供流式细胞术和免疫学服务、SIV和SHIV病毒储备和分离，以及专门的病理学服务，包括原位杂交、免疫组织化学、共聚焦显微镜和图像分析。核心还包括用于发育研究的动物和动物支持。我们期望，非人灵长类动物资源和专门研究知识与非人灵长类动物艾滋病模型的结合将增强CFAR的艾滋病研究使命，并导致新的和更强有力的合作，以及吸引新的研究人员使用非人灵长类动物艾滋病模型。