CORE--NEURAL AND DEVELOPMENTAL TOXICOLOGY

核心——神经和发育毒理学

• 批准号: 7392680
• 负责人: GEORGE WAGNER
• 金额: $ 5.99万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392680
• 关键词: Address; Age; Behavioral; Biochemical; Coupled; Data; Development; Exhibits; Goals; Impairment; Methods; Modeling; Molecular; Nervous System Trauma; Nervous system structure; Neurodegenerative Disorders; Neurosciences; Neurotoxins; Predisposition; Research; Toxic Environmental Substances; Toxicology; member; neurotoxicity; relating to nervous system; toxicant

Description (provided by applicant): The global aim of the core is to advance understanding of the mechanisms by which environmental toxicants damage the nervous system. This aim is being addressed using contemporary methods in neuroscience, coupled with approaches derived from Center members pursuing other avenues of toxicological research. The Specific Aims are to, a) elucidate the molecular and cellular changes during development, which underlie the age-specific susceptibilities to neurotoxicants; b) characterize the distinct regions of the nervous system, which exhibit differential sensitivity to environmental toxicants; c) examine the degree to which the developmental and regional sensitivity to toxicants might relate to or serve as models for neurodegenerative diseases or behavioral impairments; and d) obtain correlative molecular, biochemical, morphological and behavioral data to better understand mechanisms of neurotoxicity.

描述（由申请人提供）：核心的全球目标是促进对环境毒物损害神经系统的机制的理解。这一目标正在解决使用神经科学的当代方法，再加上来自中心成员追求毒理学研究的其他途径的方法。具体目的是：a）阐明发育过程中的分子和细胞变化，这些变化是年龄特异性神经毒物敏感性的基础; B）表征神经系统的不同区域，这些区域对环境毒物表现出不同的敏感性; c）检查发育和区域对毒物的敏感性可能与神经退行性疾病或行为障碍有关或作为其模型的程度;以及d）获得相关的分子、生物化学、形态学和行为学数据，以更好地理解神经毒性的机制。