CORE--HUMAN PHENOTYPING

核心——人类表型分析

基本信息

批准号：
7491107
负责人：
STEVEN SMITH
金额：
$ 37.87万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7491107
关键词：
Adipocytes Aging Appetitive Behavior Area Basic Science Behavior assessment Behavioral Biochemistry Biological Phenomena Biopsy Body Composition Body Weight decreased Caloric Restriction Cell Size Chromium Chronic Disease Clinical Research Clinical Sciences Commit Complex Condition Cultured Cells Data Development Diabetes Mellitus Diet Dietary Intervention Disease Energy Intake Energy Metabolism Environment Exhibits Feeding behaviors Fostering Funding Gene Expression Gene Expression Regulation Genetic Genomics Government Health Human In Situ Infiltration Insulin Insulin Resistance Intervention Intervention Trial Lead Lipids Lipoproteins Long-Term Effects Macronutrients Nutrition Maintenance Measurement Menopause Molecular Muscle Nutritional Obesity Phenotype Physical activity Physiological Play Range Regulation Research Research Infrastructure Research Personnel Research Project Grants Research Technics Reverse Transcriptase Polymerase Chain Reaction Risk Factors Role Scientist Services Signal Transduction Skeletal Muscle Structure Techniques Technology United States United States National Institutes of Health base behavior test bench to bedside bioimaging clinical phenotype design energy balance epigenomics gene interaction insulin sensitivity lifestyle intervention member programs response tool

项目摘要

The Human Phenotyping Core builds upon a strong research base in the clinical sciences encompassing a wide range of research techniques. The existing tools will be used to explore new avenues of multi-disciplinary clinical research in the area of Nutritional Programming. New data provides substantial evidence that the most common chronic diseases in the United States may have their origins in the regulation of gene expression and functioning vis-a-vis epigenomic regulation. Now, more than ever, the precise quantification of specific clinical phenotypes is essential for the application of genomic technologies and basic science discoveries to the human condition. Also, multi-disciplinary teams are needed to investigate complex, integrated biological phenomena. This Core will integrate established techniques with cutting edge measurements of in-situ biochemistry, ingestive behavior and physical activity to foster research in the area of nutritional programming.

人类的表型核心建立在临床科学的强大研究基础上包括广泛的研究技术。现有工具将用于探索营养编程领域的多学科临床研究的新途径。新的数据提供了充分的证据表明美国最常见的慢性疾病可能起源于基因表达的调节和功能性相位基因组学规定。现在，比以往任何时候都更重要的是特定临床表型的精确量化将基因组技术和基础科学发现在人类状况中的应用至关重要。此外，还需要多学科团队来调查复杂的集成生物学现象。该核心将将既定的技术与最先进的测量原位生物化学，摄取行为和体育锻炼以促进研究在营养编程领域。