REGULATION OF FOOD INTAKE AND OBESITY

食物摄入量和肥胖的调节

• 批准号: 7716402
• 负责人: Joseph W. Kemnitz
• 金额: $ 8.19万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716402
• 关键词: Aging; Animals; Appetitive Behavior; Computer Retrieval of Information on Scientific Projects Database; Desire for food; Developed Countries; Developing Countries; Diet; Energy Intake; Epidemic; Fatty acid glycerol esters; Feeding behaviors; Food Intake Regulation; Funding; Grant; Health; Healthcare Systems; Institution; Macaca mulatta; Maintenance; Modeling; Obesity; Peptides; Peripheral; Primates; Research; Research Personnel; Resources; Services; Source; Substance administration; Testing; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To identify peptides that modulate ingestive behavior in primates. Obesity has reached epidemic proportions in developed countries and this is having a profoundly negative impact on health and health care systems. Several peptides have recently been identified that may regulate appetite and feeding behaviors. We have been evaluating the effects of central and peripheral administration of these substances and their antagonists in rhesus monkeys, with the long-term aim of reducing obesity and ameliorating its consequences. In an effort to enhance the model we are using to study obesity, we developed and tested a fat-enriched maintenance diet. The diet was found to be highly palatable to rhesus monkeys and effective in increasing caloric intake. This research used WNPRC Animal Services and Aging Resources.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 确定调节灵长类动物摄入行为的肽。 肥胖症已经达到了发达国家的流行比例，这对健康和卫生保健系统产生了深远的负面影响。最近已经确定了几种可能调节食欲和喂养行为的肽。我们一直在评估这些物质及其拮抗剂在恒河猴中的中央和外围给药的影响，其长期目的是减少肥胖并改善其后果。 为了增强我们用于研究肥胖症的模型，我们开发并测试了富含脂肪的维护饮食。 发现该饮食对恒河猴非常可口，并且有效地增加了热量摄入量。 这项研究使用了WNPRC动物服务和老化资源。