2007 Molecular Mechansims in Lymphatic Function & Disease

描述(由申请人提供)： 在过去的十年中，淋巴管生物学和淋巴管生成已经成为一个快速发展的领域，在基础组织运输、了解淋巴生理和病理、免疫学、肿瘤生物学、转移和设计与淋巴系统相关疾病的新干预措施方面发挥着重要作用。在淋巴管的发育生物学和组织工程、淋巴管受体和淋巴细胞骨架结构和信号转导、生化和生物物理间质信号机制以及淋巴管和血管系统的遗传学方面创造了新的方向。淋巴研究的基础和应用领域的生物学家、生理学家、生物医学工程师和内科医生需要在一个论坛上举行会议，以促进这一领域的广泛对话并确定未来的方向。关于与肥胖、免疫抑制、充血性和继发性淋巴和组织水肿、肿瘤和转移相关的重要人类疾病的详细讨论，以及治疗性淋巴管生成的未来方向，需要得到促进。本申请旨在为将于2008年3月在加利福尼亚州文图拉举行的第三届戈登淋巴功能和疾病分子机制会议申请部分支持。这个收视率很高的两年一度的会议吸引了最大容量的世界各地的观众，他们对这个快速增长的领域有着全方位的兴趣。介绍了关于淋巴遗传学、生长和运输的丰富的基本发现。会议的广泛和长期目标是增加我们对正常和病理生理淋巴生物学和运输的基本机制的了解，重点是开发新的医学干预措施。会议的具体目标是召集38位代表淋巴研究的关键和前沿领域的演讲者，共有150名与会者参加为期5天的会议，会议的背景是最大限度地交流和规划未来的方向。这些主题包括淋巴管生成的遗传、生化和生物物理信号机制、淋巴管内皮细胞受体和信号机制、淋巴平滑肌分子生物学和生物物理学、淋巴组织血管生成和免疫学、脂肪组织、淋巴管和脂质运输之间的相互作用、淋巴管炎症、原发和继发淋巴管瓣膜系统的分子生物学、肿瘤细胞和淋巴管内皮细胞之间的转移化学吸引、淋巴疾病和相关病理的分子生物学，以及新的治疗进展。大多数出席者代表女性、少数族裔和年轻的调查人员。在戈登研究会议的传统中，会议日程和气氛旨在最大限度地提高高级和初级研究人员之间的非正式互动，并发展新的研究方向。(摘要结束)

DESCRIPTION (provided by applicant): In the past decade lymphatic vascular biology and lymphangiogenesis have become a rapidly advancing field that plays a major role in basic tissue transport, understanding of lymphatic physiology and pathology, immunology, tumor biology, metastasis, and design of new interventions for disorders associated with the lymphatic system. New directions were created in developmental biology and tissue engineering of lymphatics, lymphatic receptors and lymphatic cytoskeletal structures and signal transduction, biochemical and biophysical interstitial signaling mechanisms, as well as genetics of the lymphatic and vascular system. There is a significant need for biologists, physiologists, biomedical engineers and physicians in basic and applied areas of lymphatic research to meet in a forum that facilitates a broad dialog in this field and to determine future directions. Detailed discussion about important human diseases associated with obesity, immune suppression, congentital and secondary lymph and tissue edema, tumors and metastasis, as well as future directions in therapeutic lymph angiogenesis need to be facilitated. This application is designed to request partial support for the third Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease to be held in Ventura, California, in March 2008. This highly rated, biennial conference attracts a maximum capacity world-wide audience with a full spectrum of interests in this rapidly growing field. A rich assortment of fundamental discoveries about lymphatic genetics, growth, and transport are presented. The broad and long-term goal of the conference is to increase our understanding of the fundamental mechanisms of normal and pathophysiological lymphatic biology and transport with emphasis on development of new medical interventions. The Specific Aim of the conference is to convene 38 speakers that represent critical, cutting-edge areas of lymph research with a total of 150 participants for a five-day conference in a setting that maximizes exchange and planning of future directions. The topics include frontiers in the genetic, biochemical, and biophysical signaling mechanisms of lymphangiogenesis, lymphatic lymph endothelium receptor and signaling mechanisms, lymphatic smooth muscle molecular biology and biophysics, lymphoid tissue angiogenesis and immunology, interaction between adipose tissue, lymphatics and lipid transport, lymphatic inflammation, molecular biology of primary and secondary lymphatic valve systems, metastatic chemoattraction between tumor cells and lymphatic endothelium, molecular biology of lymphatic disease and associated pathologies, and new therapeutic developments. The majority of attendants represent women, minorities, and young investigators. In the tradition of the Gordon Research Conferences the meeting schedule and ambience is designed to maximize informal interactions between senior and junior investigators and development of new research directions. (End of Abstract)