2007 Molecular Mechansims in Lymphatic Function & Disease

2007 淋巴功能的分子机制

• 批准号: 7393930
• 负责人: Geert W. Schmid-Schoenbein
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-07 至 2009-01-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7393930
• 关键词: Adipose tissue; Area; Biochemical; Biochemical Genetics; Biology; Biomedical Engineering; Biophysics; Blood Vessels; California; Development; Developmental Biology; Disease; Edema; Endothelium; Future; Genetic; Goals; Growth; Immune; Immunology; Inflammation; Intervention; Lymph; Lymphangiogenesis; Lymphatic; Lymphatic Diseases; Lymphatic Endothelium; Lymphatic System; Lymphoid Tissue; Medical; Minority; Molecular; Molecular Biology; Neoplasm Metastasis; Obesity; Participant; Pathology; Physicians; Physiology; Play; Rate; Receptor Signaling; Research; Research Personnel; Role; Schedule; Signal Transduction; Smooth Muscle; Structure; System; Therapeutic; Tissue Engineering; Tissues; Tumor Biology; Vascular System; Woman; abstracting; angiogenesis; day; design; frontier; human disease; interest; interstitial; lipid transport; neoplastic cell; novel therapeutics; receptor; symposium; tumor

DESCRIPTION (provided by applicant): In the past decade lymphatic vascular biology and lymphangiogenesis have become a rapidly advancing field that plays a major role in basic tissue transport, understanding of lymphatic physiology and pathology, immunology, tumor biology, metastasis, and design of new interventions for disorders associated with the lymphatic system. New directions were created in developmental biology and tissue engineering of lymphatics, lymphatic receptors and lymphatic cytoskeletal structures and signal transduction, biochemical and biophysical interstitial signaling mechanisms, as well as genetics of the lymphatic and vascular system. There is a significant need for biologists, physiologists, biomedical engineers and physicians in basic and applied areas of lymphatic research to meet in a forum that facilitates a broad dialog in this field and to determine future directions. Detailed discussion about important human diseases associated with obesity, immune suppression, congentital and secondary lymph and tissue edema, tumors and metastasis, as well as future directions in therapeutic lymph angiogenesis need to be facilitated. This application is designed to request partial support for the third Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease to be held in Ventura, California, in March 2008. This highly rated, biennial conference attracts a maximum capacity world-wide audience with a full spectrum of interests in this rapidly growing field. A rich assortment of fundamental discoveries about lymphatic genetics, growth, and transport are presented. The broad and long-term goal of the conference is to increase our understanding of the fundamental mechanisms of normal and pathophysiological lymphatic biology and transport with emphasis on development of new medical interventions. The Specific Aim of the conference is to convene 38 speakers that represent critical, cutting-edge areas of lymph research with a total of 150 participants for a five-day conference in a setting that maximizes exchange and planning of future directions. The topics include frontiers in the genetic, biochemical, and biophysical signaling mechanisms of lymphangiogenesis, lymphatic lymph endothelium receptor and signaling mechanisms, lymphatic smooth muscle molecular biology and biophysics, lymphoid tissue angiogenesis and immunology, interaction between adipose tissue, lymphatics and lipid transport, lymphatic inflammation, molecular biology of primary and secondary lymphatic valve systems, metastatic chemoattraction between tumor cells and lymphatic endothelium, molecular biology of lymphatic disease and associated pathologies, and new therapeutic developments. The majority of attendants represent women, minorities, and young investigators. In the tradition of the Gordon Research Conferences the meeting schedule and ambience is designed to maximize informal interactions between senior and junior investigators and development of new research directions. (End of Abstract)

描述（由申请人提供）： 在过去的十年中，淋巴管生物学和淋巴管生成已经成为一个快速发展的领域，在基础组织运输、淋巴生理学和病理学的理解、免疫学、肿瘤生物学、转移和与淋巴系统相关的疾病的新干预措施的设计中发挥重要作用。在发育生物学和组织工程的淋巴管，淋巴受体和淋巴细胞骨架结构和信号转导，生物化学和生物物理间质信号传导机制，以及淋巴和血管系统的遗传学方面创造了新的方向。淋巴研究的基础和应用领域的生物学家，生理学家，生物医学工程师和医生非常需要在一个论坛上会面，以促进该领域的广泛对话并确定未来的方向。详细讨论与肥胖，免疫抑制，先天性和继发性淋巴和组织水肿，肿瘤和转移，以及在治疗淋巴血管生成的未来方向有关的重要人类疾病需要促进。此申请旨在请求对将于2008年3月在加州文图拉举行的第三届戈登淋巴功能和疾病分子机制会议的部分支持。这个评价很高的两年一次的会议吸引了全世界最大容量的观众，他们对这个快速发展的领域感兴趣。一个关于淋巴遗传学，生长和运输的基本发现丰富的品种。会议的广泛和长期目标是增加我们对正常和病理生理淋巴生物学和运输的基本机制的理解，重点是开发新的医疗干预措施。会议的具体目标是召集38位代表淋巴研究关键前沿领域的演讲者，共有150名与会者参加为期五天的会议，最大限度地交流和规划未来方向。主题包括淋巴管生成的遗传，生物化学和生物物理信号机制的前沿，淋巴管内皮受体和信号机制，淋巴平滑肌分子生物学和生物物理学，淋巴组织血管生成和免疫学，脂肪组织之间的相互作用，代谢和脂质转运，淋巴炎症，初级和次级淋巴瓣膜系统的分子生物学，肿瘤细胞和淋巴管内皮之间的转移性化学吸引，淋巴疾病和相关病理的分子生物学，以及新的治疗进展。大多数与会者代表妇女、少数民族和年轻的研究人员。在戈登研究会议的传统，会议时间表和氛围的目的是最大限度地提高高级和初级研究人员之间的非正式互动和新的研究方向的发展。(End摘要）