2008 Cell Biology of the Neuron

描述（由申请人提供）：“神经元细胞生物学”戈登会议将于2008年6月举行第八届，已成为讨论快速发展的细胞神经生物学领域进展的首要国际会议。会议的重点将放在神经功能的细胞生物学方面。会议将涵盖多种跨学科方法，包括遗传、分子、细胞、生物物理和行为方法来理解大脑。会议将代表从秀丽隐杆线虫到人类的各种模型系统。今年将涵盖以下主题：突触发育，突触前机制，突触后信号，轴突和树突形态发生，皮质连接，成像电路和突触可塑性。被选中的演讲者都是该领域最活跃的人，也是善于表达的思想家，他们应该通过将自己的工作和想法与其他领域的工作和想法结合起来，产生有益的讨论。这种形式包括20分钟的演讲，然后是10分钟或更长时间的讨论。会议花名册上既有前途光明、事业刚刚起步的年轻科学家，也有成熟的科学家。演讲者中有9位是女性，5位来自美国以外。此外，还保留了8个名额，供选择演讲者就令人兴奋的最新发展进行简短演讲。大多数参与者（演讲者除外）将展示其作品的海报，以确保参与者之间最大程度的沟通和思想交流。本次会议以跨学科的神经机制为重点，对理解情感和行为障碍、大脑发育中的遗传缺陷、心理健康和药物成瘾具有特别的兴趣。强调神经发育和可塑性与儿童健康和发展有关。演讲者包括专门研究药物耐受性和成瘾的分子基础、情感和认知障碍（如焦虑和自闭症）、大脑发育中的遗传缺陷和衰老疾病（如阿尔茨海默氏症和帕金森病）的研究人员。本次会议对包括NIMH、NINDS、NICHD、NIA、NIDA和NIAAA在内的研究所的任务具有巨大的潜在兴趣。本提案请求基金支持将于2008年6月举行的“神经元细胞生物学”戈登研究会议。这次会议汇集了各种各样的神经生物学家，他们都研究大脑的基本组成部分，神经元和突触。特别地，这次会议将重点介绍大脑如何发展其复杂的突触连接，以及这些连接在发育过程中或在不同疾病状态下如何被修改的最新发现。因此，这次会议将进一步推动几个研究所的使命，包括NIGMS， NINDS， NIMH， NIDA， NEI和NIAAA。

DESCRIPTION (provided by applicant): The "Cell Biology of the Neuron" Gordon Conference, to be held for the eighth time in June 2008, has become the premier international meeting for discussing progress in the rapidly moving field of cellular neurobiology. The focus of the meeting will be on the cell biological aspects of neural function. The meeting will encompass a diverse set of interdisciplinary approaches, including genetic, molecular, cellular, biophysical, and behavioral approaches to understanding the brain. A diverse set of model systems will be represented at the meeting, ranging from C. elegans to humans. This year the following themes will be covered: synapse development, pre-synaptic mechanisms, post-synaptic signaling, axon and dendrite morphogenesis, cortical connectivity, imaging circuits, and synaptic plasticity. The chosen speakers are among the most active in the field and are also articulate thinkers who should generate useful discussion by integrating their work and ideas with those in other fields. The format consists of 20 minute talks followed by a discussion of 10 minutes or more. The meeting roster contains a mixture of promising young scientists near the beginning of their careers and established scientists. Nine of the speakers are women and five are from outside the US. In addition, eight slots are being kept open to select speakers for short talks on exciting, late-breaking developments. Most participants (except speakers) will present posters on their work, ensuring maximum communication and exchange of ideas among participants. With its interdisciplinary focus on neural mechanisms, this conference is of special interest for understanding affective and behavioral disorders, hereditary defects in brain development, mental health and drug addiction. The emphasis on neural development and plasticity has relevance for child health and development. The speakers include investigators who are specifically studying the molecular basis of drug tolerance and addiction, affective and cognitive disorders (e.g. anxiety and autism), hereditary defects in brain development, and diseases of aging such as Alzheimer's and Parkinson,s diseases. The conference should be of great potential interest to the missions of institutes including NIMH, NINDS, NICHD, NIA, NIDA and NIAAA. This proposal requests fund to support the "Cell Biology of the Neuron" Gordon Research Conference, to be held in June 2008. This conference brings together a diverse set of neurobiologists, all of whom study the fundamental building blocks of the brain, neurons and synapses. In particular, this meeting will highlight recent discoveries in how the brain develops its complex set of synaptic connections, and how these connections are modified during development, or in different disease states. Thus, this meeting will further the mission of several institutes, including NIGMS, NINDS, NIMH, NIDA, NEI, and NIAAA. .