Yeast Chromosome Structure, Replication and Segregation

描述(申请人提供)：第九届酵母染色体结构、复制和分离会议将于2006年6月24-29日在加利福尼亚州的印第安威尔斯举行，随后将于2008年(第10届会议)和2010年(第11届会议)举行。会议将为学生、博士后和高级调查人员提供多达250个名额，让他们见面并讨论过去一年的新发现。这次会议是一个非常成功的系列中的最新一次迭代，该系列独特地结合了研究染色体功能不同方面的研究人员。像过去一样，受邀的演讲者将介绍他们的最新作品，其中一些演讲选自摘要。此外，还有充足的时间进行讨论和海报演示。 对酵母染色体结构的研究，以及染色体复制和分离的机制和控制，继续以快速的速度进行，并为哺乳动物细胞的相关研究奠定了基础。最近的进展提供了对核组织、组蛋白修饰在染色质沉默和DNA损伤反应中的作用、DNA复制的控制、蛋白质降解在细胞周期转变中的作用特别是染色体分离、检查点反应的分子途径、动粒结构和功能、端粒维持与DNA双链断裂修复之间的联系以及有丝分裂纺锤体的组装和功能等方面的新见解。由于生化、细胞生物学和遗传工具的强大组合，以及最近酵母研究人员可以使用的基因组技术，芽殖酵母和分裂酵母的研究在许多领域处于领先地位。酵母细胞使用的大部分蛋白质和机制在人类细胞中是保守的，这使得这项工作与人类生物学直接相关。事实上，染色体功能和基因组完整性是人类健康的许多方面的基础，并直接与癌症、衰老和出生缺陷有关。所有这些都以正常染色体功能的中断为特征，这一点很容易在酵母中进行研究。

DESCRIPTION (provided by applicant): The 9th Yeast Chromosome Structure, Replication, and Segregation Conference sponsored by FASEB will be held on 24-29 June, 2006 at Indian Wells, California, and thereafter in 2008 (10th Conference) and 2010 (11th Conference). The Conference will provide up to 250 places for students, postdocs, and senior investigators to meet and discuss novel findings of the past year. This conference is the latest iteration in a highly successful series that uniquely combines researchers investigating different aspects of chromosome function. As in the past, invited speakers will present their most recent work, with some talks chosen from the abstracts. In addition, there is ample time for discussion and poster presentations. Research into yeast chromosome structure, and the mechanisms and control of chromosome replication and segregation, continues at a rapid pace and underpins related research in mammalian cells. Recent advances provide new insights into nuclear organization, the role of histone modification in chromatin silencing and DNA damage response, the control of DNA replication, the role of protein degradation in cell cycle transitions in general and chromosome segregation in particular, the molecular pathways of checkpoint responses, kinetochore structure and function, the connection between telomere maintenance and DNA double stranded break repair, and the assembly and function of the mitotic spindle. Because of the powerful combination of biochemical, cell biological, and genetic tools, as well as more recently genomic technologies now at the disposal of yeast researchers, studies in budding and fission yeasts have led the field in many of these areas. Most of the proteins and mechanisms employed by yeast cells are conserved in human cells, making this work directly relevant to human biology. Indeed, chromosome function and genome integrity are fundamental to many aspects of human health, and are directly implicated in cancer, aging, and birth defects. All of these are characterized by disruptions in normal chromosome function, which can be readily studied in yeast.