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Birth, Muscle Injury and Pelvic Floor Dysfunction

出生、肌肉损伤和盆底功能障碍

基本信息

批准号：
7288130
负责人：
JOHN O.L. DELANCEY
金额：
$ 112.67万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-25 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7288130
关键词：
3-Dimensional Accounting Acute Address Adult Adverse event Affect African American Age Aging American Anatomy Anterior Anterior vaginal wall prolapse Anthropology Anus Apical Area Athletic Injuries Atrial Natriuretic Factor Attention Award Basic Science Behavior Biological Assay Biological Factors Biomechanics Biomedical Engineering Biometry Biostatistics Core Birth Birth trauma Bladder Body Image Budgets Businesses Cadaver Caliber Cancer Center Planning Grant Caring Case-Control Studies Categories Cell Nucleus Cells Cellular biology Cephalopelvic Disproportions Cesarean section Characteristics Childbirth Chronic Clinical Clinical Data Clinical Research Clinical Trials Closure Collection Complex Computer Simulation Computer software Computers Condition Confidentiality Conflict (Psychology)Connective Tissue Control Groups Cost Savings Daily Data Data Analyses Data Files Data Quality Data Set Databases Decision Analysis Defect Denervation Dental crowns Detection Deterioration Development Diagnostic Dimensions Direct Costs Discipline Discipline of Nursing Discipline of obstetrics Disease Disruption Distal Distress Doctor of Philosophy Early Diagnosis Edema Educational workshop Elastic Tissue Elderly Elements End Point Energy Metabolism Engineering Ensure Enterocele Environment Epidemic Epidemiologist Epidural Anesthesia Episiotomy Equipment Etiology Evaluation Event Exercise Failure Fascia Fatigue Fecal Incontinence Feeling Fees Fellowship Female First Births Forcep Fostering Frequencies Functional disorder Funding Future Gender Gender Issues Generations Genetic Predisposition to Disease Gerontology Goals Grant Gray unit of radiation dose Group Meetings Growth and Development function Gynecologist Gynecology Hand Head Health Health Priorities High Prevalence Home environment Housing Human Human Resources Hybrids Image Image Analysis Incidence Incontinence Individual Infant Inferior Injury Inpatients Institutes Institution Interdisciplinary Study Intervention Intervention Studies Invasive Investigation Isometric Exercise Knee Knowledge Label Laceration Lead Learning Left Length Life Life Style Lifting Light Linear Models Link Liquid substance Localized Location Longevity MRI Scans Magnetic Resonance Magnetic Resonance Elastography Magnetic Resonance Imaging Maintenance Measurement Measures Mechanical Stress Mechanics Medical Medicine Menopause Mentors Mentorship Michigan Minor Minority Mission Modeling Molecular Molecular Biology Monitor Morbidity - disease rate Morphology Mothers Muscle Muscle Contraction Muscle Tonus Muscle strain NCI Scholars Program National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases Nature Neonatal Numbers Nurse Midwives Nurse Practitioners Nurses Odds Ratio Operative Surgical Procedures Organ Outcome Outcomes Research Paralysed Participant Pathology Patient currently pregnant Patients Pattern Pelvic Floor Disorders Pelvic Floor Muscle Pelvic floor dysfunction Pelvic floor structure Pelvis Phase Physiological Physiology Population Population Heterogeneity Population Study Positioning Attribute Postmenopause Postpartum Period Predisposition Pregnancy Pregnant Women Preparation Prevalence Prevention Prevention strategy Preventive Principal Investigator Procedures Process Progress Review Group Property Prophylactic treatment Proprotein Convertase 2 Protocols documentation Protons Psychology Ptosis Public Health Public Health Nurses Public Health Nursing Public Health Schools Publications Published Comment Quality Control Quality of life Questionnaires Race Randomized Controlled Clinical Trials Range Rate Rattus Recording of previous events Recovery Recruitment Activity Rectocele Rectum Regulation Rehabilitation therapy Relative (related person)Relative Risks Reporting Reproductive Process Research Research Design Research Ethics Committees Research Infrastructure Research Institute Research Personnel Research Project Grants Research Subjects Research Support Resistance Resolution Resources Rest Risk Risk Factors Role Rupture Safety Saimiri Sampling Scanning Schedule Scholarship Schools Science Scientist Second Labor Stage Series Services Sexual Dysfunction Shame Shapes Signal Transduction Simulate Site Smooth Muscle Social Interaction Societies Source Specific qualifier value Specimen Speculums Speed Staging Standards of Weights and Measures Statistical Models Strategic Planning Stress Stress Urinary Incontinence Stretching Striated Muscles Structure Students Study Section Study models Surgeon Surveys Symptoms TNFRSF5 gene Taboo Techniques Technology Testing Textiles Thick Thinking Three-dimensional analysis Time TimeLine Tissues Training Trauma Ultrasonography Uncontrolled Study United States United States National Institutes of Health Universities Urethra Urethral sphincter Urinary Incontinence Urodynamics Urologist Urology Vagina Vaginal Prolapses Vaginal delivery procedure Validation Variant Week Weight Weight Gain Woman Women&apos s Health Work advanced maternal age age related base biomechanical engineering career case control caucasian American child bearing clinically relevant clinically significant cohort collaboratory cost data acquisition data management day density design experience fetal functional loss genetic epidemiology health disparity hip bone human subject improved injured injury prevention innovation insight instrument interest levator ani muscle medical schools men model development multidisciplinary muscle strength neglect nerve injury new technology novel parity practical application pressure prevent programs psychologic pubis bone structure rectal repaired reproductive research clinical testing research study sex simulation size social soft tissue sphincter ani muscle structure success symposium theories tissue trauma tool urinary volunteer

项目摘要

DESCRIPTION (provided by applicant): This proposal seeks to improve care for the women who suffer the priority health conditions of pelvic floor dysfunction; problems that arise due to women's unique role in giving birth. It addresses the sex disparities that exist in these problems. Each year 3 million women deliver babies and 300,000 women need surgery for pelvic floor dysfunction. A lack of basic understanding of the mechanisms of birth-related injury and recovery during reproductive years and mechanisms of prolapse later in life block efforts to prevent damage, improve recovery, or improve treatment. We seek continued support for a broadly interdisciplinary group of researchers from 4 schools and 2 institutes to that has expedited development of new knowledge needed to improve treatment and prevention. Project 1: "Birth Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor injury during vaginal birth; the single largest factor in causing pelvic floor dysfunction to identify specific situations may increase or decrease injury risk. Project 2: "Injury Recovery" will identify risk factors associated with levator injury, test the hypothesis that these injuries are, in fact, related to vaginal delivery and determine early predictors of eventual recovery. Project 3, "Mechanisms of Posterior Vaginal Prolapse" will use advanced imaging and deformation analysis to test hypotheses concerning the basic disease mechanisms responsible for posterior vaginal wall prolapse, one of the most common and strongly birth-associated pelvic floor dysfunction. Core A: Administrative / Human Subjects / Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Science Futures to discuss expanding the issues raised by this research. Core B: Measurement and Imaging core will provide technical support for the projects along with integrated analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce insights to address the women's health problem of pelvic floor dysfunction

描述（由申请人提供）：本提案旨在改善对盆底功能障碍优先健康状况的妇女的护理；由于妇女在分娩中的独特作用而产生的问题。它解决了这些问题中存在的性别差异。每年有300万妇女分娩，30万妇女因盆底功能障碍需要手术。缺乏对生育期间出生相关损伤和恢复机制以及生命后期脱垂机制的基本了解，阻碍了预防损伤、改善恢复或改善治疗的努力。我们寻求继续支持一个由来自4所学校和2个研究所的广泛跨学科研究人员组成的小组，该小组加快了改善治疗和预防所需新知识的开发。项目一：“分娩生物力学”将检验关于阴道分娩时盆底损伤基本机制的假设；导致盆底功能障碍的最大因素是确定具体情况可能增加或减少损伤风险。项目2：“损伤恢复”将确定与提肛肌损伤相关的风险因素，测试这些损伤实际上与阴道分娩有关的假设，并确定最终恢复的早期预测因素。项目3，“阴道后壁脱垂的机制”将使用先进的成像和变形分析来检验关于阴道后壁脱垂的基本疾病机制的假设，阴道后壁脱垂是最常见和与出生密切相关的盆底功能障碍之一。核心A：行政/人类受试者/生物统计学核心通过招募受试者、汇编和分析数据以及保护受试者安全为项目提供支持。在核心A中，将形成两个研究小组，分别涉及1)性别影响和2)基础科学未来，以讨论扩大本研究提出的问题。核心B：测量和成像核心将为项目提供技术支持，并对项目收集的二维和三维空间数据进行综合分析。这项研究将产生见解，以解决妇女盆底功能障碍的健康问题