Biostatistics and Biomechanical Measurement Core

生物统计学和生物力学测量核心

基本信息

批准号：
8549849
负责人：
JOHN O.L. DELANCEY
金额：
$ 29.16万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8549849
关键词：
3-Dimensional Address Biomechanics Biomedical Engineering Biometry Birth Cadaver Clinical Collaborations Complex Conceptions Data Data Analyses Data Base Management Database Management Systems Defect Engineering Faculty Fostering Funding Goals Grant Histology Injury Institutional Review Boards Instruction Magnetic Resonance Imaging Measurement Measures Mechanics Mentors Methods Muscle Pelvic floor dysfunction Pelvic floor structure Physicians Physiology Property Research Design Research Personnel Research Project Grants Scientific Advances and Accomplishments Scientist Secure Services Speculums Staging Techniques Testing Three-Dimensional Imaging Tissues Training Ultrasonography Vagina Woman Writing data acquisition data management design elastography graduate student human subject industry partner instrument instrumentation novel research study user-friendly

项目摘要

The Biostatistical and Biomechanical Measurements Core (BBMC) will provide biostatistics and biomechanical support to SCOR Projects I, II, and III. AIM1 is to assist with study design, power analyses and data analysis plans. AIM 2 is to provide engineering support for experimental, clinical and 3-D imaging measurements. AIM 3 is to provide support for database management and information exchange across SCOR Projects. AIM 4 is to conduct high quality statistical analyses across SCOR Projects, and AIM 5 is to provide mentoring and training of young investigators in these methods in conjunction with Core C. Core B will assist with technical aspects of tissue property and quantitative histology measurements in Project 1 (30 cadavers), as well as human subjects measurements (n=60) in Project 1. In Project 11 it will assist with post-natal quantification of pubovisceral muscles and their defects in MR images from up to 88 women. In Project 111 it will assist with measurements of vaginal support using biomechanical instrumentation, standardized 3-D MR images and clinical measurements in up to 100 women. Finally, Core B will continue to foster new academic collaborations and interface with industry partners, developing novel instrumentation and analytical techniques as needed.

生物统计和生物力学测量核心（BBMC）将为SCOR项目I，II和III提供生物力学和生物力学支持。 AIM1是协助研究设计，功率分析和数据分析计划。 AIM 2是为实验，临床和3-D成像测量提供工程支持。 AIM 3是在SCOR项目中为数据库管理和信息交换提供支持。 AIM 4是在SCOR项目中进行高质量的统计分析，并且 AIM 5是在这些方法中与CoreC结合提供对年轻研究者的指导和培训。核心B将有助于项目1（30尸体）中组织特性和定量组织学测量的技术方面，以及项目1中的人类受试者的测量（n = 60）。在项目11中，它将有助于对Pubovisceral Muscles及其在MR图像中的缺陷及其在MR图像中的缺陷进行量化。在项目111中，它将使用生物力学仪器，标准化的3-D MR图像和多达100名女性的临床测量来帮助测量阴道支持。最后，Core B将继续促进新的学术合作，并与行业合作伙伴进行交互，并根据需要开发新颖的工具和分析技术。