Biostatistics and Biomechanical Measurement Core

生物统计学和生物力学测量核心

• 批准号: 8549849
• 负责人: JOHN O.L. DELANCEY
• 金额: $ 29.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8549849
• 关键词: 3-Dimensional; Address; Biomechanics; Biomedical Engineering; Biometry; Birth; Cadaver; Clinical; Collaborations; Complex; Conceptions; Data; Data Analyses; Data Base Management; Database Management Systems; Defect; Engineering; Faculty; Fostering; Funding; Goals; Grant; Histology; Injury; Institutional Review Boards; Instruction; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Mentors; Methods; Muscle; Pelvic floor dysfunction; Pelvic floor structure; Physicians; Physiology; Property; Research Design; Research Personnel; Research Project Grants; Scientific Advances and Accomplishments; Scientist; Secure; Services; Speculums; Staging; Techniques; Testing; Three-Dimensional Imaging; Tissues; Training; Ultrasonography; Vagina; Woman; Writing; data acquisition; data management; design; elastography; graduate student; human subject; industry partner; instrument; instrumentation; novel; research study; user-friendly

The Biostatistical and Biomechanical Measurements Core (BBMC) will provide biostatistics and biomechanical support to SCOR Projects I, II, and III. AIM1 is to assist with study design, power analyses and data analysis plans. AIM 2 is to provide engineering support for experimental, clinical and 3-D imaging measurements. AIM 3 is to provide support for database management and information exchange across SCOR Projects. AIM 4 is to conduct high quality statistical analyses across SCOR Projects, and AIM 5 is to provide mentoring and training of young investigators in these methods in conjunction with Core C. Core B will assist with technical aspects of tissue property and quantitative histology measurements in Project 1 (30 cadavers), as well as human subjects measurements (n=60) in Project 1. In Project 11 it will assist with post-natal quantification of pubovisceral muscles and their defects in MR images from up to 88 women. In Project 111 it will assist with measurements of vaginal support using biomechanical instrumentation, standardized 3-D MR images and clinical measurements in up to 100 women. Finally, Core B will continue to foster new academic collaborations and interface with industry partners, developing novel instrumentation and analytical techniques as needed.

生物统计和生物力学测量核心 (BBMC) 将为 SCOR 项目 I、II 和 III 提供生物统计和生物力学支持。 AIM1 旨在协助研究设计、功效分析和数据分析计划。 AIM 2 旨在为实验、临床和 3D 成像测量提供工程支持。 AIM 3 旨在为 SCOR 项目之间的数据库管理和信息交换提供支持。 目标 4 是在 SCOR 项目中进行高质量的统计分析，并且 AIM 5 旨在与核心 C 一起为年轻研究者提供这些方法的指导和培训。 核心 B 将协助项目 1（30 具尸体）中的组织特性和定量组织学测量的技术方面，以及项目 1 中的人类受试者测量（n=60）。在项目 11 中，它将协助对多达 88 名女性的 MR 图像中的耻骨内脏肌肉及其缺陷进行产后量化。在 Project 111 中，它将使用生物力学仪器、标准化 3D MR 图像和临床测量来协助多达 100 名女性测量阴道支撑。最后，核心 B 将继续促进新的学术合作以及与行业合作伙伴的联系，根据需要开发新颖的仪器和分析技术。