Birth, Muscle Injury and Pelvic Floor Dysfunction

出生、肌肉损伤和盆底功能障碍

• 批准号: 8131257
• 负责人: JOHN O.L. DELANCEY
• 金额: $ 9.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8131257
• 关键词: 3-Dimensional; Address; Anesthetics; Anterior; Basic Science; Behavior; Biomechanics; Biostatistics Core; Birth; Caliber; Caring; Cephalopelvic Disproportions; Cesarean section; Data; Data Analyses; Dental crowns; Development; Disease; Elastic Tissue; Elements; Episiotomy; Forcep; Future; Gender; Head; Health Priorities; Human; Image; Injury; Institutes; Isometric Exercise; Knowledge; Life; Location; Measurement; Measures; Minor; Modeling; Muscle; Muscle Contraction; Muscle strain; Nature; Operative Surgical Procedures; Paralysed; Pelvic Floor Muscle; Pelvic floor dysfunction; Pelvic floor structure; Predisposition; Pregnancy; Pregnant Women; Prevention; Property; Ptosis; Rattus; Recording of previous events; Recovery; Recruitment Activity; Research; Research Personnel; Resistance; Risk; Risk Factors; Role; Rupture; Safety; Saimiri; Schools; Second Labor Stage; Shapes; Simulate; Specimen; Speculums; Spinal; Staging; Stress; Testing; Time; Tissues; Traction; Tube; Vagina; Vaginal Prolapses; Vaginal delivery procedure; Validation; Weight; Woman; Women' s Health; fetal; human subject; improved; insight; instrument; levator ani muscle; pregnant; pressure; prevent; reproductive; sex; sphincter ani muscle structure; volunteer

This proposal seeks to improve care for the women who suffer the priority health conditions of pelvic floor dysfunction; problems that arise due to women's unique role in giving birth. It addresses the sex disparities that exist in these problems. Each year 3 million women deliver babies and 300,000 women need surgery for pelvic floor dysfunction. A lack of basic understanding of the mechanisms of birth-related injury and recovery during reproductive years and mechanisms of prolapse later in life block efforts to prevent damage, improve recovery, or improve treatment. We seek continued support for a broadly interdisciplinary group of researchers from 4 schools and 2 institutes to that has expedited development of new knowledge needed to improve treatment and prevention. Project 1: "Birth Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor injury during vaginal birth; the single largest factor in causing pelvic floor dysfunction to identify specific situations may increase or decrease injury risk. Project 2: "Injury Recovery" will identify risk factors associated with levator injury, test the hypothesis that these injuries are, in fact, related to vaginal delivery and determine early predictors of eventual recovery. Project 3, "Mechanisms of Posterior Vaginal Prolapse" will use advanced imaging and deformation analysis to test hypotheses concerning the basic disease mechanisms responsible for posterior vaginal wall prolapse, one of the most common and strongly birth-associated pelvic floor dysfunction. Core A: Administrative / Human Subjects / Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Science Futures to discuss expanding the issues raised by this research. Core B: Measurement and Imaging core will provide technical support for the projects along with integrated analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce insights to address the women's health problem of pelvic floor dysfunction.

该提案旨在改善对患有骨盆底优先健康状况的妇女的护理 功能障碍;由于妇女在分娩中的独特作用而产生的问题。它解决了性别差异， 存在于这些问题中。每年有300万妇女分娩，30万妇女需要手术 治疗骨盆底功能障碍对产伤机制缺乏基本了解， 生殖期的恢复和生命后期脱垂的机制阻碍了防止损害的努力， 改善恢复或改善治疗。我们寻求继续支持一个广泛的跨学科小组， 来自4所学校和2个研究所的研究人员加速了所需新知识的发展， 改善治疗和预防。 项目1：“出生生物力学”将测试有关骨盆底损伤的基本机制的假设 阴道分娩期间;导致盆底功能障碍的单一最大因素，以确定具体情况 可能会增加或减少受伤的风险。 项目2：“损伤恢复”将识别与提肌损伤相关的风险因素，检验以下假设： 事实上，这些损伤与阴道分娩有关，并决定了最终康复的早期预测因素。 项目3，“后阴道脱垂的机制”将使用先进的成像和变形分析 为了检验关于导致阴道后壁脱垂的基本疾病机制的假设， 最常见的和强烈的出生相关的骨盆底功能障碍之一。 核心A：行政/人类受试者/生物统计学核心通过招募受试者提供项目支持， 编辑和分析数据，保护受试者安全。在核心A中，将形成两个研究组 关于（1）性别影响和（2）基础科学未来，讨论扩大这一问题所提出的问题， research. 核心B：测量和成像核心将为项目提供技术支持，沿着集成 分析跨项目收集的二维和三维空间数据。这项研究将产生见解， 解决女性盆底功能障碍的健康问题。