Birth, Muscle Injury and Pelvic Floor Dysfunction

这项建议旨在改善对患有盆底优先健康状况的妇女的护理 功能障碍；由于妇女在生育中的独特作用而出现的问题。它解决了性别差异问题 这些问题中存在的问题。每年有300万妇女接生，30万妇女需要手术 盆底功能障碍。对出生相关伤害的发生机制缺乏基本认识 生殖年间的恢复和生命后期脱垂的机制阻碍了防止损害的努力， 提高恢复率，或改善治疗。我们寻求继续支持一个广泛的跨学科小组 来自4所学校和2个研究所的研究人员加快了所需新知识的开发 提高治疗和预防水平。 项目1：“分娩生物力学”将测试有关盆底损伤基本机制的假说。 在阴道分娩期间；导致盆底功能障碍的单一最大因素，以确定特定情况 可能会增加或降低受伤风险。 项目2：“损伤恢复”将确定与提升器损伤相关的风险因素，检验假设 事实上，这些损伤与阴道分娩有关，并决定了最终康复的早期预测因素。 项目3“阴道后脱垂的机制”将使用先进的成像和变形分析 为了测试关于导致阴道后壁脱垂的基本疾病机制的假设， 盆底功能障碍是最常见也是与出生密切相关的疾病之一。 核心A：行政/人类科目/生物统计学核心通过招募科目提供项目支持， 整理和分析数据，保护受试者安全。在核心A中，将组成两个学习小组 关于1)性别影响和2)基础科学未来，以讨论扩大 研究。 核心B：测量和成像核心将为项目提供技术支持，以及集成 对跨项目收集的二维和三维空间数据进行分析。这项研究将产生深刻的见解 解决女性盆底功能障碍的健康问题。

This proposal seeks to improve care for the women who suffer the priority health conditions of pelvic floor dysfunction; problems that arise due to women's unique role in giving birth. It addresses the sex disparities that exist in these problems. Each year 3 million women deliver babies and 300,000 women need surgery for pelvic floor dysfunction. A lack of basic understanding of the mechanisms of birth-related injury and recovery during reproductive years and mechanisms of prolapse later in life block efforts to prevent damage, improve recovery, or improve treatment. We seek continued support for a broadly interdisciplinary group of researchers from 4 schools and 2 institutes to that has expedited development of new knowledge needed to improve treatment and prevention. Project 1: "Birth Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor injury during vaginal birth; the single largest factor in causing pelvic floor dysfunction to identify specific situations may increase or decrease injury risk. Project 2: "Injury Recovery" will identify risk factors associated with levator injury, test the hypothesis that these injuries are, in fact, related to vaginal delivery and determine early predictors of eventual recovery. Project 3, "Mechanisms of Posterior Vaginal Prolapse" will use advanced imaging and deformation analysis to test hypotheses concerning the basic disease mechanisms responsible for posterior vaginal wall prolapse, one of the most common and strongly birth-associated pelvic floor dysfunction. Core A: Administrative / Human Subjects / Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Science Futures to discuss expanding the issues raised by this research. Core B: Measurement and Imaging core will provide technical support for the projects along with integrated analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce insights to address the women's health problem of pelvic floor dysfunction.