ORWH: SCOR on Sex and Gender Factors Affecting Women's *

描述（由申请人提供）： 该提案旨在改善对患有尿失禁和盆腔器官脱垂等优先健康状况的妇女的护理。这些问题的出现是由于妇女在分娩中的独特作用，因此，在男子中发生的情况要少得多。每年有300万妇女分娩，11%的妇女需要手术治疗尿失禁和脱垂。缺乏对这些疾病的机制及其对治疗的影响的基本了解阻碍了进展。我们建议建立一个SCOR，以联合5名现有的多学科研究人员，并增加4名新的研究人员，以加快开发改善治疗和预防所需的新知识。项目1，“生物力学”将测试有关骨盆底结构和功能的基本机制的假设。它将分析骨盆底组成部分的机械排列和特性，以及阴道分娩如何损害其完整性。项目2，“临床机制”将测试大陆和压力性尿失禁的妇女，以检测独特的失败的组成部分，单独和组合，与压力性尿失禁。项目3，“治疗选择”将确定分娩引起的肌肉损伤对压力性尿失禁妇女的影响，并从这些数据中建立和测试模型，以确定哪些缺陷将预测骨盆肌肉治疗的成功或失败。核心A，管理/人类受试者/生物统计学核心通过招募受试者、编辑和分析数据以及保护受试者安全提供项目支持。在核心A中，将成立两个研究小组，分别涉及（1）性别影响和（2）基础科学未来，以讨论扩大这项研究提出的问题。核心B，测量和成像将为项目提供技术支持，沿着集成图像分析，用于跨项目收集的二维和三维空间数据。这项研究将产生所需的见解，以帮助女性盆底功能障碍。

DESCRIPTION (provided by applicant): This proposal seeks to improve care for the women who suffer the priority health conditions of urinary incontinence and pelvic organ prolapse. These problems arise due to women's unique role in giving birth and, therefore, occur much less often in men. Each year 3 million women deliver babies and 11 % of women need surgery for incontinence and prolapse. A lack of basic understanding of the mechanisms involved in these conditions and their implications for treatment impedes progress. We propose a SCOR to unite 5 existing multidisciplinary researchers and to add 4 new investigators to expedite development of new knowledge needed to improve treatment and prevention. Project 1, "Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor structure and function. It will analyze the mechanical arrangement and properties of the components of the pelvic floor as well as how vaginal birth damages their integrity. Project 2, "Clinical Mechanisms" will test continent and stress incontinent women to detect the unique failure of component parts that, singularly and in combinations, are associated with stress incontinence. Project 3, "Treatment Selection" will identify the effects of birth induced muscle damage in women with stress incontinence and from these data, build and test a model to determine which defects will predict success or failure of pelvic muscle treatment. Core A, Administrative/Human Subjects/Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Sciences Futures to discuss expanding the issues raised by this research. Core B, Measurement & Imaging will provide technical support for the projects along with integrated image analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce needed insights to help women with pelvic floor dysfunction.