ORWH: SCOR on Sex and Gender Factors Affecting Women's *

ORWH：影响女性的性和性别因素的 SCOR *

• 批准号: 6575865
• 负责人: JOHN O.L. DELANCEY
• 金额: $ 106.97万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6575865
• 关键词: clinical research; human subject; urinary incontinence; women's health

DESCRIPTION (provided by applicant): This proposal seeks to improve care for the women who suffer the priority health conditions of urinary incontinence and pelvic organ prolapse. These problems arise due to women's unique role in giving birth and, therefore, occur much less often in men. Each year 3 million women deliver babies and 11 % of women need surgery for incontinence and prolapse. A lack of basic understanding of the mechanisms involved in these conditions and their implications for treatment impedes progress. We propose a SCOR to unite 5 existing multidisciplinary researchers and to add 4 new investigators to expedite development of new knowledge needed to improve treatment and prevention. Project 1, "Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor structure and function. It will analyze the mechanical arrangement and properties of the components of the pelvic floor as well as how vaginal birth damages their integrity. Project 2, "Clinical Mechanisms" will test continent and stress incontinent women to detect the unique failure of component parts that, singularly and in combinations, are associated with stress incontinence. Project 3, "Treatment Selection" will identify the effects of birth induced muscle damage in women with stress incontinence and from these data, build and test a model to determine which defects will predict success or failure of pelvic muscle treatment. Core A, Administrative/Human Subjects/Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Sciences Futures to discuss expanding the issues raised by this research. Core B, Measurement & Imaging will provide technical support for the projects along with integrated image analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce needed insights to help women with pelvic floor dysfunction.

描述（由申请人提供）： 该提议旨在改善遭受尿失禁和骨盆器官脱垂优先健康状况的妇女的护理。这些问题是由于女性在分娩中的独特作用而引起的，因此在男性中发生的频率要少得多。每年有300万妇女分娩婴儿，11％的妇女需要手术治疗尿失禁和脱垂。缺乏对这些疾病中涉及的机制及其对治疗的影响的基本了解会阻碍进步。我们提出一个SCOR，以团结5名现有的多学科研究人员，并添加4位新的研究人员，以加快改善治疗和预防所需的新知识的发展。项目1“生物力学”将检验有关骨盆底结构和功能基本机制的假设。它将分析骨盆底部成分的机械排列和特性，以及阴道出生如何损害其完整性。项目2“临床机制”将测试非洲大陆和压力失盗的妇女，以检测组件部分的独特失败，这些部分与压力尿失禁有关。项目3，“治疗选择”将确定出生诱导的肌肉损害对压力尿失禁的女性的影响，并通过这些数据，构建和测试模型，以确定哪些缺陷将预测骨盆肌肉治疗的成功或失败。核心A，行政/人类受试者/生物统计学核心通过招募主题，编译和分析数据并保护主题安全来提供项目支持。在核心A中，将成立两个研究小组，以了解1）性别影响和2）基本科学期货，以讨论扩大本研究提出的问题。核心B，测量和成像将为项目提供技术支持，以及针对跨项目收集的2和3维空间数据的集成图像分析。这项研究将产生所需的见解，以帮助骨盆底功能障碍的女性。