Cell Growth and Survival

细胞生长和存活(CGS)计划的重点是调节生长的信号通路， 正常细胞和肿瘤细胞的存活和死亡。这项研究的目标是开发新的战略 利用这种理解来改进抗癌治疗。CGS计划目前有27名科学家 来自维克森林大学医学院10个系的成员。会员资格的变更 自2000年上次审查以来的CGS方案反映了具体的、有针对性的招聘以改进 整合节目的主要主题。这些变化现在正在产生红利，在以下方面 科学生产力。该项目的总资金大幅增长，从244万美元增加到 S438万年度同行评审资金的直接成本。此外，科学合作的程度已经 在本供资期间，以该方案的主要主题为中心，这一数字显著增加。CGS 计划成员在2001-2005年间发表了242篇同行评议文章。在这些人中，20%至少有两个CG 计划成员作为共同作者，而在2000年的审查中，这一比例为5%。2004年，道格拉斯·莱尔斯博士 教授兼生物化学主席，被任命为CGS计划主任(前主任， 索伯恩博士离职后在科罗拉多大学担任癌症中心领导职位)。莱尔斯医生已经 26年来一直是CCCWFU的成员。他对病毒组装和病毒与宿主相互作用的研究 为开发治疗癌症的新型溶瘤病毒带来了新的想法。他认为 2004年担任生物化学系主任，坚定地致力于招聘新的教员 在癌症研究方面继续加强现有的实质性关系 生物化学系和CCCWFU。莱尔斯博士的任命进一步整合了 在这个项目中的教师发展。以下部分重点介绍了CGS中选定的主要主题 程序。来自CGS计划对国家癌症努力的几项新贡献已经显现为 自上次审查以来的主题。它们是：1)维生素D和食用大豆之间迷人的协同作用 异黄酮类化合物对前列腺癌和乳腺癌增殖的调节作用；2)膳食效应的探讨 脂类对癌细胞增殖和转移的影响；3)活性氧作为信号转导的新作用 与细胞增殖有关的分子；4)低氧时的翻译调控和内质网应激；5)低氧时的 先天抗肿瘤免疫机制的遗传控制；6)抗病毒和抗病毒药物的拮抗关系 增殖信号与新型溶瘤病毒的发展。这些主题直接反映了 CCCWFU带来的增值：癌症中心的主题开发和教师招聘 领导力；由计划主任领导这些主题的发展；高度 在CGS内部和与其他计划的合作，主要参与英才中心，以及 有效利用共享设施。

The Cell Growth and Survival (CGS) Program is focused on the signaling pathways that regulate the growth, survival and death of normal and neoplastic cells. The goal of this research is to develop novel strategies that exploit this understanding to improve anti-cancer therapy. The CGS Program currently has 27 scientific members from 10 departments in the Wake Forest University School of Medicine. Changes in membership of the CGS program since the previous review in 2000 reflect specific, targeted recruiting to improve integration of the major themes of the program. These changes are now paying dividends in terms of scientific productivity. This program has undergone substantial growth in its total funding, from $2.44M to S4.38M direct costs in annual peer-reviewed funding. In addition, the extent of scientific collaboration has increased markedly during the present funding period, centered on the major themes of the Program. CGS Program members published 242 peer-reviewed articles in 2001-2005. Of these, 20% had at least two CGS program members as coauthors, compared to 5% in the review in 2000. In 2004, Dr. Douglas Lyles, Professor and Chair of Biochemistry, was appointed as Director of the CGS Program (the previous director, Dr. Thorburn, left to assume a cancer center leadership position at University of Colorado). Dr. Lyles has been a member of the CCCWFU for 26 years. His research on virus assembly and virus-host interactions has led to new ideas for the development of novel oncolytic viruses for the treatment of cancer. He assumed the chairmanship of the Department of Biochemistry in 2004 with a strong commitment to recruit new faculty in cancer research and to continue to strengthen the substantial existing relationship between the Department of Biochemistry and the CCCWFU. Dr. Lyles' appointment has further integrated efforts in faculty development within this program. The following sections highlight selected major themes in the CGS program. Several novel contributions from the CGS Program to the national cancer effort have emerged as themes since the previous review. They are: 1) a fascinating synergy between vitamin D and dietary soy isoflavones in regulation of proliferation in prostate and breast cancer; 2) explorations of the effects of dietary lipids on cancer cell proliferation and metastasis; 3) a novel role of reactive oxygen species as signaling molecules in cell proliferation; 4) translational control and endoplasmic reticulum stress in hypoxia, 5) the genetic control of innate anti-tumor immune mechanisms; and 6) the antagonistic relationship of antiviral and proliferative signaling and the development of novel oncolytic viruses. These themes directly reflect the value-added as a result of the CCCWFU: thematic development and faculty recruiting by the Cancer Center leadership; shepherding the development of these themes by the Program Director; a high degree of collaboration within the CGS and with other Programs, major participation in the Centers of Excellence, and effective use of shared facilities.