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Cell Growth and Survival

细胞生长和存活

基本信息

批准号：
7529427
负责人：
DOUGLAS S. LYLES
金额：
$ 1.58万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-11 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7529427
关键词：
Affect Antiviral Agents Antiviral Response Apoptosis Apoptotic Appointment Area Basic Science Biochemistry Bioinformatics Biological Markers Biology Biostatistics Core Brain Neoplasms Breast Breast Cancer Treatment Cancer Biology Cancer Cell Growth Cancer Center Cancer Control Cell Death Cell Proliferation Cell Proliferation Regulation Cells Cessation of life Clinical Research Clinical Trials Collaborations Colorado Complementary and alternative medicine Comprehensive Cancer Center of Wake Forest University Computational Biology Core Facility Cultured Cells DNA Sequence Data Analyses Dendritic Cells Development Dietary Factors Dietary Fats Dietary Intervention Direct Costs Electron Microscopy Facility Employee Strikes Endoplasmic Reticulum Enzymes Epidemiologic Studies Epithelial Cells Faculty Fluorescence Focus Groups Funding Gene Expression Generations Genes Genetic Genetic Polymorphism Genomics Glioma Goals Growth Heart Diseases Human Hypoxia Immune Immune response Immunity Immunologic Surveillance Immunologist Indium Induction of Apoptosis Inflammation Inflammatory Institutes Investigation Iris Isoflavones Laboratories Lead Leadership Left Link Lipids Malignant Neoplasms Malignant neoplasm of prostate Mass Spectrum Analysis Mathematics Mediating Metabolism Microscopy Modeling Modification Molecular Target Mus Mutant Strains Mice Natural Immunity Neoplasm Metastasis Oncolytic viruses Oxidation-Reduction Oxygen Oxygen measurement, partial pressure, arterial Pathway interactions Patients Peer Review Phosphoric Monoester Hydrolases Platelet Activating Factor Play Polyunsaturated Fatty Acids Positioning Attribute Post-Translational Protein Processing Predisposition Prevention Primates Process Production Productivity Prostate Prostatic Protein Analysis Proteins Proteomics Publishing Radiation therapy Radiosensitization Reactive Oxygen Species Recombinants Recruitment Activity Regulation Reporting Research Research Personnel Research Project Grants Resistance Resources Risk Rodent Model Role Sampling Series Signal Pathway Signal Transduction Signaling Molecule Solid Neoplasm Specimen Standards of Weights and Measures Stress Systems Biology T-Lymphocyte Technology Therapeutic Thinking Time Toll-like receptors Transcriptional Regulation Translating Translational Research Translations Tumor Tissue Universities Viral Genome Viral Vector Virginia Virus Virus Assembly Virus Diseases Vitamin D Vitamin D Analog Work Zemplar anticancer research base bench to bedside biological adaptation to stress cancer cell cancer therapy cell growth cell growth regulation cell injury chemotherapeutic agent computer science concept cysteinesulfenic acid fascinate forest improved interest killings lycopene malignant breast neoplasm medical schools member multidisciplinary mutant neoplastic cell novel novel strategies outcome forecast professor programs prohormone rapid growth soy soy protein isolate success synergism trait transcription factor tumor tumorigenesis virus host interaction

项目摘要

The Cell Growth and Survival (CGS) Program is focused on the signaling pathways that regulate the growth, survival and death of normal and neoplastic cells. The goal of this research is to develop novel strategies that exploit this understanding to improve anti-cancer therapy. The CGS Program currently has 27 scientific members from 10 departments in the Wake Forest University School of Medicine. Changes in membership of the CGS program since the previous review in 2000 reflect specific, targeted recruiting to improve integration of the major themes of the program. These changes are now paying dividends in terms of scientific productivity. This program has undergone substantial growth in its total funding, from $2.44M to S4.38M direct costs in annual peer-reviewed funding. In addition, the extent of scientific collaboration has increased markedly during the present funding period, centered on the major themes of the Program. CGS Program members published 242 peer-reviewed articles in 2001-2005. Of these, 20% had at least two CGS program members as coauthors, compared to 5% in the review in 2000. In 2004, Dr. Douglas Lyles, Professor and Chair of Biochemistry, was appointed as Director of the CGS Program (the previous director, Dr. Thorburn, left to assume a cancer center leadership position at University of Colorado). Dr. Lyles has been a member of the CCCWFU for 26 years. His research on virus assembly and virus-host interactions has led to new ideas for the development of novel oncolytic viruses for the treatment of cancer. He assumed the chairmanship of the Department of Biochemistry in 2004 with a strong commitment to recruit new faculty in cancer research and to continue to strengthen the substantial existing relationship between the Department of Biochemistry and the CCCWFU. Dr. Lyles' appointment has further integrated efforts in faculty development within this program. The following sections highlight selected major themes in the CGS program. Several novel contributions from the CGS Program to the national cancer effort have emerged as themes since the previous review. They are: 1) a fascinating synergy between vitamin D and dietary soy isoflavones in regulation of proliferation in prostate and breast cancer; 2) explorations of the effects of dietary lipids on cancer cell proliferation and metastasis; 3) a novel role of reactive oxygen species as signaling molecules in cell proliferation; 4) translational control and endoplasmic reticulum stress in hypoxia, 5) the genetic control of innate anti-tumor immune mechanisms; and 6) the antagonistic relationship of antiviral and proliferative signaling and the development of novel oncolytic viruses. These themes directly reflect the value-added as a result of the CCCWFU: thematic development and faculty recruiting by the Cancer Center leadership; shepherding the development of these themes by the Program Director; a high degree of collaboration within the CGS and with other Programs, major participation in the Centers of Excellence, and effective use of shared facilities.

细胞生长和存活 (CGS) 计划专注于调节生长的信号通路，正常细胞和肿瘤细胞的存活和死亡。这项研究的目标是制定新颖的策略利用这种理解来改善抗癌治疗。 CGS 计划目前有 27 项科学成员来自维克森林大学医学院的 10 个系。成员资格的变化自 2000 年上次审查以来 CGS 计划的进展反映了具体的、有针对性的招募，以改善计划的主要主题的整合。这些变化现在正在带来红利科学生产力。该计划的总资金大幅增长，从 244 万美元增加到 S4.38M 年度同行评审资金的直接成本。此外，科学合作的程度在当前供资期间，围绕该计划的主要主题显着增加。中国地质调查局 2001 年至 2005 年期间，计划成员发表了 242 篇同行评审文章。其中，20% 至少拥有两项 CGS 计划成员作为共同作者，而 2000 年审查中的比例为 5%。2004 年，Douglas Lyles 博士，教授兼生物化学系主任，被任命为CGS项目主任（前任主任， Thorburn 博士，离开后担任科罗拉多大学癌症中心的领导职务）。莱尔斯博士有成为 CCCWFU 会员已 26 年。他对病毒组装和病毒与宿主相互作用的研究引发了开发用于治疗癌症的新型溶瘤病毒的新想法。他假设 2004年担任生物化学系系主任，坚定致力于招募新教师癌症研究并继续加强之间的实质性现有关系生物化学系和CCCWFU。莱尔斯博士的任命进一步整合了以下方面的努力：该计划内的教师发展。以下部分重点介绍 CGS 中选定的主要主题程序。 CGS 计划对国家癌症工作做出的几项新贡献如下：自上次审查以来的主题。它们是：1) 维生素 D 和食用大豆之间令人着迷的协同作用异黄酮调节前列腺癌和乳腺癌的增殖； 2）饮食影响的探索脂质对癌细胞增殖和转移的影响； 3）活性氧作为信号传导的新作用细胞增殖中的分子； 4）缺氧时的翻译控制和内质网应激，5）先天抗肿瘤免疫机制的遗传控制； 6）抗病毒药物和抗病毒药物的拮抗关系增殖信号传导和新型溶瘤病毒的开发。这些主题直接反映了 CCCWFU 带来的增值：癌症中心的主题开发和教师招聘领导;由项目主任引导这些主题的发展；高度 CGS 内部以及与其他计划的合作，主要参与卓越中心，以及有效利用共享设施。