Structural and Computational Biophysics Training Program

描述（由申请人提供）：本提案旨在从国家普通医学科学研究所（NIGMS）的分子生物物理学计划中为NRSA机构博士前培训补助金提供资金。该补助金将支持结构和计算生物物理学（SCB）的博士前培训，以获得博士学位。在维克森林大学获得学位。SCB培训计划的目标是弥合生物医学科学和更基础的定量科学之间的培训差距。SCB培训教师是跨部门的高度合作，包括物理，化学，生物化学和分子医学的教师。学生接受结构生物学（X射线和NMR），计算生物学，蛋白质组学和生物物理学的培训。SCB培训计划的主要科学主题包括DNA损伤和修复，氧化还原生物学和分子信号的重叠领域。该计划有一个灵活的课程，旨在满足学生在该计划的个人需求，并包括一个跨学科研讨会和教程，以促进该计划的成员之间的互动发达的系统。除了SCB培训教师，谁将担任导师的博士。除了培养学生外，我们还有一个完善的资源教师网络，通过教育创新，核心实验室的方向，对结构生物学和生物物理学的培训至关重要，并提供职业咨询和与生物技术行业的网络，为研究生的培训做出贡献。我们为我们的博士提供各种潜在职业的特定技能培训。毕业生，包括学术生涯，在生物技术和制药行业的职业生涯，以及在知识产权竞技场的职业生涯。我们已经开发了一个管道，其中物理，数学和计算机科学硕士学位的学生可以获得结构和计算生物物理学证书，提供了一个过渡到博士学位。在我们的培训计划中。同样，我们有一个优秀的跟踪记录，从事博士。学生在生物科学的结构和计算研究。我们有一个积极的计划，从科学领域代表性不足的少数民族中招募学生参加我们的培训计划。在培训学院实验室的25-30名学生的稳定状态水平中，要求为4个博士前职位提供资金。这些职位将用于支持学生在第二年或以后，在这个时候，它将是显而易见的，他们的论文研究是符合该计划的目标。支持将最多两年，之后学生将由他们的顾问或他们自己的个人奖学金的研究资金支持。

DESCRIPTION (provided by applicant): This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Molecular Biophysics Program of the National Institute for General Medical Sciences (NIGMS). This grant will support predoctoral training in Structural and Computational Biophysics (SCB) leading to a Ph.D. degree at Wake Forest University. The goal of the SCB Training Program is to bridge the gap in training between biomedical sciences and more basic quantitative sciences. The SCB training faculty is highly collaborative across departmental lines, and includes faculty members from Physics, Chemistry, Biochemistry, and Molecular Medicine. Students are trained in structural biology (X-ray and NMR), computational biology, proteomics, and biophysics. The major scientific themes of the SCB Training Program include the overlapping areas of DNA damage and repair, redox biology, and molecular signaling. The Program has a flexible curriculum that is designed to meet the individual needs of the students in the program, and includes a well-developed system of interdisciplinary seminars and tutorials to promote interaction among members of the program. In addition to the SCB training faculty, who will serve as mentors for Ph.D. students, we also have a well-established network of resource faculty that contribute to the training of graduate students through educational innovation, direction of Core Laboratories that are central to training in structural biology and biophysics, and provision of career advice and networking with biotechnology industries. We offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including academic careers, careers in the biotechnology and pharmaceutical industries, as well as careers in the intellectual property arena. We have developed a pipeline in which Masters' degree students in Physics, Mathematics and Computer Science can obtain a certificate in Structural and Computational Biophysics that provides a transition into Ph.D. training in our program. Similarly, we have an excellent track record of engaging Ph.D. students in biological sciences in structural and computational research. We have an active program of recruiting students from ethnic groups that are underrepresented in science into our training program. Funding is requested for 4 predoctoral positions out of the steady state level of 25-30 students in the laboratories of the training faculty. These positions will be used to support students in the second year or beyond, at which time it will be apparent that their dissertation research is consistent with the goals of the Program. Support will be for a maximum of two years, after which the students will be supported by the research funding of their advisors or their own individual fellowships.