Structural and Computational Biophysics Training Program

结构和计算生物物理学培训计划

• 批准号: 8691895
• 负责人: DOUGLAS S. LYLES
• 金额: $ 18.05万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8691895
• 关键词: Biophysics; Training Programs

DESCRIPTION (provided by applicant): This proposal seeks funding for an NRSA Institutional Predoctoral Training Grant from the Molecular Biophysics Program of the National Institute for General Medical Sciences (NIGMS). This grant will support predoctoral training in Structural and Computational Biophysics (SCB) leading to a Ph.D. degree at Wake Forest University. The goal of the SCB Training Program is to bridge the gap in training between biomedical sciences and more basic quantitative sciences. The SCB training faculty is highly collaborative across departmental lines, and includes faculty members from Physics, Chemistry, Biochemistry, and Molecular Medicine. Students are trained in structural biology (X-ray and NMR), computational biology, proteomics, and biophysics. The major scientific themes of the SCB Training Program include the overlapping areas of DNA damage and repair, redox biology, and molecular signaling. The Program has a flexible curriculum that is designed to meet the individual needs of the students in the program, and includes a well-developed system of interdisciplinary seminars and tutorials to promote interaction among members of the program. In addition to the SCB training faculty, who will serve as mentors for Ph.D. students, we also have a well-established network of resource faculty that contribute to the training of graduate students through educational innovation, direction of Core Laboratories that are central to training in structural biology and biophysics, and provision of career advice and networking with biotechnology industries. We offer specific training in skills for a wide variety of potential careers for our Ph.D. graduates, including academic careers, careers in the biotechnology and pharmaceutical industries, as well as careers in the intellectual property arena. We have developed a pipeline in which Masters' degree students in Physics, Mathematics and Computer Science can obtain a certificate in Structural and Computational Biophysics that provides a transition into Ph.D. training in our program. Similarly, we have an excellent track record of engaging Ph.D. students in biological sciences in structural and computational research. We have an active program of recruiting students from ethnic groups that are underrepresented in science into our training program. Funding is requested for 4 predoctoral positions out of the steady state level of 25-30 students in the laboratories of the training faculty. These positions will be used to support students in the second year or beyond, at which time it will be apparent that their dissertation research is consistent with the goals of the Program. Support will be for a maximum of two years, after which the students will be supported by the research funding of their advisors or their own individual fellowships.

描述(由申请人提供)：本提案寻求从国家普通医学科学研究所(NIGMS)的分子生物物理学计划中获得NRSA机构博士前培训补助金。这笔赠款将支持在维克森林大学获得博士学位的结构和计算生物物理学(SCB)博士前培训。SCB培训计划的目标是弥合生物医学科学和更基础的定量科学之间的培训差距。SCB的培训人员跨部门高度协作，包括来自物理、化学、生物化学和分子医学的教员。学生接受结构生物学(X射线和核磁共振)、计算生物学、蛋白质组学和生物物理学方面的培训。SCB培训计划的主要科学主题包括DNA损伤和修复、氧化还原生物学和分子信号的重叠领域。该计划有一个灵活的课程，旨在满足计划中学生的个人需求，并包括一套完善的跨学科研讨会和教程系统，以促进计划成员之间的互动。除了担任博士生导师的渣打大学培训学院外，我们还拥有完善的资源教师网络，通过教育创新、对结构生物学和生物物理学培训至关重要的核心实验室的指导，以及提供职业建议和与生物技术行业建立网络，为研究生的培训做出贡献。我们为我们的博士毕业生提供针对各种潜在职业的具体技能培训，包括学术职业、生物技术和制药行业的职业以及知识产权领域的职业。我们开发了一条管道，让物理学、数学和计算机科学的硕士研究生可以获得结构和计算生物物理学的证书，这将为我们的项目提供过渡到博士培训的机会。同样，我们在让生物科学博士生参与结构和计算研究方面也有很好的记录。我们有一个积极的计划，将科学领域中代表性不足的少数族裔的学生纳入我们的培训计划。在培训学院实验室的25-30名学生的稳定水平中，需要为4个博士前职位申请经费。这些职位将被用来支持第二年或以后的学生，那时他们的论文研究显然与项目的目标是一致的。资助期限最长为两年，在此之后，学生将由其导师的研究经费或自己的个人奖学金提供支持。