Retrovirology Services

核心H：反病毒学服务 LIFESPAN/Tuft/Brown CFAR的反病毒服务核心(核心H)的具体目标是(1) 为CFAR调查人员提供基本的病毒学实验室服务，以支持他们以艾滋病毒-1为中心的基础 科学调查，重点是初级调查人员和那些接受CFAR的个人 发展资助奖，(2)处理和存档正在进行的单站点和多站点的临床标本 试验(AACTG、HPTN、HVTN、SUN)，以及(3)促进艾滋病毒-1基础科学培训/教育 CFAR机构的博士后学生和参加布朗/塔夫茨大学的个人 Fogarty艾滋病国际研究培训计划(D43TW000237)。核心于#年开始运行 在过去的4年里创造和维护了3500平方英尺的新 有强有力的制度支持的实验室空间。这一基础设施最近已被七家公司部分使用 招募了从事艾滋病毒-1病毒学各个方面工作的初级调查人员。所有七个人都有 他们的各种项目获得了新的联邦和/或私人资金。目前，对的研究兴趣 核心用户分为以下大类：杀微生物剂的设计和交付、抗逆转录病毒的进化 资源贫乏地区的抗药性，开发艾滋病毒-1及其相关的新治疗方法 恶性肿瘤和感染，HIV-1生殖器负担的特征，设计最佳HIV-1治疗 难以接触到的人口或居住在资源贫乏地区的人的范例以及对 HIV-1感染的自然病史。在当前授权期内，核心将维持所有当前的检测 和存档功能，并扩大服务范围，为基于RNAi的分析提供工具。在……里面 此外，核心将协助调查人员进行小动物实验，以支持NIH 资助杀微生物剂设计和投放的调查。核心将继续管理50,000+ 存档临床样本，并支持CFAR教职员工进行新的临床试验。核心意志 继续以收费方式向最近获得资助的调查人员提供化验支持，并继续 支持未获得独立资助的初级教职员工的有功项目。

Core H: Retrovirology Services The specific aims of the Retrovirology Services Core (Core H) of the Lifespan/Tufts/Brown CFAR are to (1) Provide basic virology laboratory services to CFAR investigators in support of their HIV-1 centered basic science investigation with emphasis on junior investigators and those individuals who have received CFAR developmental grant awards, (2) Process and archive clinical specimens from ongoing single and multi-site trials (AACTG, HPTN, HVTN, SUN), and (3) Facilitate the HIV-1 basic science training/education of pre- and postdoctoral students at CFAR institutions and those individuals participating in the Brown/Tufts University Fogarty AIDS International Research Training Program (D43TW000237). The Core began operations in September of 2002 and over the past 4 years has created and maintained 3500 square feet of new laboratory space with strong institutional support. This infrastructure has been used in part by seven recently recruited junior investigators working on various aspects of HIV-1 virology. All seven individuals have received new federal and/or private funding for their various projects. Presently, the research interests of Core users fall into the following broad categories: Microbicide design and delivery, Evolution of antiretroviral resistance in resource-poor areas, Development of novel therapeutic approaches to HIV-1 and related malignancies and infections, Characterization of HIV-1 genital burden, Designing optimum HIV-1 treatment paradigms in hard-to-reach populations or those residing in resource poor areas and, Longitudinal studies of the natural history of HIV-1 infection. In the current granting period, the Core will maintain all current assay and archiving capabilities and expand the range of services to provide tools for RNAi based assays. In addition, the Core will assist investigators in performing experiments with small animals in support of NIH funded investigations of microbicide design and delivery. The Core will continue to manage the 50,000+ archive of clinical samples and support the pursuit of new clinical trials by CFAR faculty. The Core will continue to offer assay support to recently funded investigators on a fee-for-service basis and continue to support meritorious projects by junior faculty who have not garnered independent grant support.