SCID Mouse : Human Xenograft Core

SCID小鼠：皮肤异种移植核心利用严重联合免疫缺陷（SCID）米色双突变小鼠以分裂厚度皮肤移植物或合成皮肤结构的形式宿主人类皮肤（和皮肤相关细胞）。核心的三个具体目标是：(1)为YSDRC的成员（包括成熟的和初级的研究者，包括YSDRC P/F项目的研究者）提供有限数量的c - b -17 SCID/beige小鼠移植健康成人皮肤或用于各种皮肤的皮肤构建物

The SCID Mouse: Skin xenograft core utilizes severe combined immunodeficient (SCID) beige double mutant mice to host living of human skin (and skin-related cells) in the form of split thickness skin grafts or synthetic skin constructs. The three specific aims of the core are (1) to provide members of the YSDRC (both established and junior investigators, including investigators with YSDRC P/F projects) with limited numbers of C.B-17 SCID/beige mice engrafted with healthy adult human skin or skin constructs for use in a variety of skin disease-related studies, including feasibility studies; (2) to train members of the YSDRC to generate such mice once feasibility has been established; and (3) to develop variant models of this technique for new and novel applications, specifically focussing on synthetic skin equivalents constructed from distinct populations of cells, that in some cases may be genteically modified to alter biologic functions.