SCID Mouse : Human Xenograft Core

SCID小鼠：皮肤异种移植核心利用严重联合免疫缺陷(SCID)米色双突变小鼠，以中厚皮肤移植或合成皮肤结构的形式寄生人类皮肤(和皮肤相关细胞)。该核心的三个具体目标是：(1)向YSDRC成员(包括YSDRC P/F项目的调查人员)提供有限数量的C.B-17 SCID/Beige小鼠，植入健康的成人皮肤或皮肤构造，用于各种皮肤 与疾病相关的研究，包括可行性研究；(2)一旦可行性确定，训练YSDRC的成员产生这种小鼠；以及(3)开发这项技术的变种模型，用于新的和新的应用，特别是专注于由不同的细胞群体构建的合成皮肤等价物，在某些情况下，可能会经过绅士式的修改，以改变生物功能。

The SCID Mouse: Skin xenograft core utilizes severe combined immunodeficient (SCID) beige double mutant mice to host living of human skin (and skin-related cells) in the form of split thickness skin grafts or synthetic skin constructs. The three specific aims of the core are (1) to provide members of the YSDRC (both established and junior investigators, including investigators with YSDRC P/F projects) with limited numbers of C.B-17 SCID/beige mice engrafted with healthy adult human skin or skin constructs for use in a variety of skin disease-related studies, including feasibility studies; (2) to train members of the YSDRC to generate such mice once feasibility has been established; and (3) to develop variant models of this technique for new and novel applications, specifically focussing on synthetic skin equivalents constructed from distinct populations of cells, that in some cases may be genteically modified to alter biologic functions.