SCID Mouse : Human Xenograft Core

SCID 小鼠：人类异种移植核心

• 批准号: 7392297
• 负责人: JORDAN S POBER
• 金额: $ 9.84万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392297
• 关键词: Adult; Allogenic; Autologous; B-Lymphocytes; Blood Cells; Cells; Cutaneous; Development; Endothelium; Engraftment; Family suidae; Feasibility Studies; Future; Human; Life; Modeling; Mus; Mutant Strains Mice; Neonatal; Numbers; Population; Preparation; Research Personnel; SCID Mice; Skin; Skin graft; Sus scrofa; T-Lymphocyte; Techniques; Technology; Thick; Time; Training; Variant; Work; Xenograft Model; Xenograft procedure; implantation; in vivo; member; neutrophil; novel; penis foreskin; research study; skin disorder; skin xenograft; tumor; vascular bed; volunteer

The SCID Mouse: Skin xenograft core utilizes severe combined immunodeficient (SCID) beige double mutant mice to host living of human skin (and skin-related cells) in the form of split thickness skin grafts or synthetic skin constructs. The three specific aims of the core are (1) to provide members of the YSDRC (both established and junior investigators, including investigators with YSDRC P/F projects) with limited numbers of C.B-17 SCID/beige mice engrafted with healthy adult human skin or skin constructs for use in a variety of skin disease-related studies, including feasibility studies; (2) to train members of the YSDRC to generate such mice once feasibility has been established; and (3) to develop variant models of this technique for new and novel applications, specifically focussing on synthetic skin equivalents constructed from distinct populations of cells, that in some cases may be genteically modified to alter biologic functions.

SCID小鼠：皮肤异种移植核心利用严重联合免疫缺陷（SCID）米色双突变小鼠以分层厚度皮肤移植物或合成皮肤构建体的形式宿主人皮肤（和皮肤相关细胞）的存活。核心的三个具体目标是（1）为YSDRC的成员（既有成熟的研究者，也有初级研究者，包括YSDRC P/F项目的研究者）提供有限数量的C.B-17 SCID/米色小鼠，这些小鼠移植有健康的成年人皮肤或皮肤构建体，用于各种皮肤 疾病相关的研究，包括可行性研究;（2）一旦可行性已经建立，训练YSDRC的成员产生这样的小鼠;和（3）开发用于新的和新颖的应用的该技术的变体模型，特别关注由不同的细胞群体构建的合成皮肤等同物，在某些情况下，可以通过遗传修饰来改变生物功能。