Underage Alcohol Use: Sequence and Progression of Early Drinking Milestones

描述（由申请人提供）：尽管美国的法律的饮酒年龄是21岁，但未成年人饮酒非常普遍，甚至是规范性的。早期饮酒与许多后续适应不良结果的风险增加有关，包括重度或问题饮酒，发展酒精使用障碍的可能性，其他物质参与和行为问题。然而，对未成年饮酒者的早期饮酒过程的研究相对不足。该应用程序的目标是探索早期饮酒生涯的特征，包括与饮酒相关的里程碑的顺序和进展，如第一次饮酒，第一次醉酒，第一次定期饮酒，第一次酗酒，以及第一次经历与酒精相关的问题。此外，尽管早发性与晚发性患者的早期饮酒过程可能不同，但这种关联的性质尚不清楚。与问题行为理论和工作表明，早发性个体可能会更快地发展为有问题的酒精使用和相关问题，这与早发性个体和随后的酒精参与的常见脆弱性一致。相比之下，早发性个体由于酒精的社会和身体可用性有限，可能进展较慢。该研究项目将使用三个二级数据集，包括国家青少年健康纵向研究（AddHealth），国家青年纵向调查（NLSY 97）和青少年药物滥用治疗结果研究（DATOS-A），对青少年早期至中期的饮酒过程进行分析。其中两个数据集是具有全国代表性的前瞻性样本，第三个是治疗样本，对不同里程碑的开始年龄进行了丰富的评估。这三个数据集的不同特征允许解决发挥每个数据集优势的具体问题。此外，通过使用临床治疗样本，我们可以描述饮酒过程中的高风险样本谁已经开始大量饮酒，这将补充使用两个一般人群样本的结果，主要包括青少年的饮酒是在一个非常早期和非危险的阶段。本研究的具体目的是通过早期饮酒里程碑来探索正常的以及个体间和个体内的进展速度变化，并使用项目反应理论建模、生存分析和潜在转换分析的技术来研究早期饮酒过程与外源性、内源性、分组和混杂变量的关联。当这些具体的目标得到满足，我们将能够更好地了解第一次饮酒年龄的预后意义，我们将更接近了解是否年轻人显示早期危险饮酒不同于一般人群，他们的经验与各种早期饮酒里程碑。

DESCRIPTION (provided by applicant): Although the legal drinking age in the United States is age 21, underage drinking is highly prevalent, even normative. Early onset of alcohol use is associated with increased risk of a number of subsequent maladaptive outcomes, including heavy or problem drinking, likelihood of developing an alcohol use disorder, other substance involvement, and behavioral problems. However, early course of drinking among underage drinkers has been relatively understudied. The goal of this application is to explore characteristics of the early drinking career including sequencing of and progression through drinking-related milestones such as first drink, first time drunk, first regular drinking, first binge drinking, and first experience of an alcohol-related problem. In addition, although it is likely that early drinking course differs for those with early versus late onset, the nature of this association is unclear. Consistent with problem behavior theory and work showing common vulnerability to early initiation and subsequent alcohol involvement, early onset individuals may have a more rapid progression to problematic alcohol use and related problems. In contrast, early onset individuals may progress more slowly due to the limited social and physical availability of alcohol. This research project will conduct analysis of drinking course in early- to mid- adolescence using three secondary datasets, including the National Longitudinal Study of Adolescent Health (AddHealth), the National Longitudinal Survey of Youth (NLSY97), and the Drug Abuse Treatment Outcome Study for Adolescents (DATOS-A). Two of these datasets are nationally representative prospective samples and the third is a treatment sample which has a rich assessment of age of initiation of different milestones. The different characteristics of the three datasets permit resolution of specific questions that play to the strengths of each dataset. In addition, by using a clinical treatment sample, we can depict drinking course among a high-risk sample who has already initiated heavy drinking which will complement findings using two general population samples primarily comprised of adolescents whose drinking is at a very early and non-risky stage. Specific aims of the proposed study are to explore normative as well as inter- and intra-individual variation in velocity of progression through early drinking milestones, and to examine the association of early drinking course with exogenous, endogenous, grouping, And confounding variables using techniques of item response theory modeling, survival analysis, and latent transition analysis. When these specific aims are met, we will better be able to understand the prognostic significance of age of first drink and we will be closer to understanding whether youth who show early risky drinking differ from the general population with regard to their experience with various early drinking milestones.