Identification and characterization of novel proteins in endosomal cholesterol transport

内体胆固醇转运中新型蛋白质的鉴定和表征

• 批准号: nhmrc : 1041301
• 负责人: Prof Andrew Brown
• 金额: $ 36.05万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterization-novel-cholesterol-transport/111368
• 关键词: Identification; characterization; novel; proteins; endosomal

Abnormal subcellular distribution of cholesterol is associated with a number of common diseases including heart disease and Alzheimer’s disease. The overall aim of this proposal is to identify and characterize novel molecules that regulate the transport of intracellular cholesterol. Results from the proposed studies will provide important insights into the molecular mechanisms governing intracellular cholesterol transport and distribution, and will lead to better treatment strategies against heart disease and dementia.

胆固醇的异常亚细胞分布与包括心脏病和阿尔茨海默病在内的许多常见疾病有关。这项提议的总体目标是确定和表征调节细胞内胆固醇运输的新分子。拟议研究的结果将为控制细胞内胆固醇运输和分布的分子机制提供重要见解，并将导致更好的治疗心脏病和痴呆的策略。