Lipid trafficking at membrane contact sites: the role of Oxysterol-Binding Protein-Related Protein 5 and 8 (ORP5 and ORP8)

膜接触位点的脂质运输：氧甾醇结合蛋白相关蛋白 5 和 8（ORP5 和 ORP8）的作用

• 批准号: nhmrc : GNT1141939
• 负责人: Prof Andrew Brown
• 金额: $ 46.64万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipid-trafficking-membrane-orp5-orp8/1348418
• 关键词: Lipid; trafficking; membrane; contact; sites

Abnormal subcellular lipid distribution is associated with a number of common diseases including cancer, cardiovascular disease, and Alzheimer’s disease. The overall aim of this proposal is to identify and characterize new molecules that regulate the transport of lipids between different cell membranes. Results from the proposed studies will help developing novel therapeutic agents against common human diseases.

亚细胞脂质分布异常与许多常见疾病相关，包括癌症、心血管疾病和阿尔茨海默病。该提案的总体目标是确定和表征调节不同细胞膜之间脂质转运的新分子。拟议研究的结果将有助于开发针对常见人类疾病的新型治疗药物。