Novel control points in cholesterol synthesis

胆固醇合成的新控制点

• 批准号: nhmrc : 1008081
• 负责人: Prof Andrew Brown
• 金额: $ 24.45万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-control-points-cholesterol-synthesis/109278
• 关键词: Novel; control; points; cholesterol; synthesis

Our goal is to discover new mechanisms involved in our cells’ delicate balancing act with respect to cholesterol levels. Understanding how production of cholesterol is controlled in our cells is key to developing new drugs aimed at preventing its excessive accumulation. This will have long-term benefits for health considering that a cellular imbalance in cholesterol is involved in two of the most common conditions threatening the health of Australians, namely heart disease and Alzheimer’s disease.

我们的目标是发现与我们的细胞在胆固醇水平方面的微妙平衡有关的新机制。了解胆固醇的产生是如何在我们的细胞中被控制的，是开发旨在防止其过度积累的新药的关键。考虑到威胁澳大利亚人健康的两种最常见疾病，即心脏病和阿尔茨海默病与细胞胆固醇失衡有关，这将对健康产生长期益处。