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Characterising an important control point in cholesterol synthesis beyond HMG-CoA reductase

Characterising an important control point in cholesterol synthesis beyond HMG-CoA reductase
表征 HMG-CoA 还原酶之外的胆固醇合成的重要控制点
批准号：
nhmrc : 1060515
负责人：
Prof Andrew Brown
金额：
$32.06万
依托单位：
The University of New South Wales
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2014
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2014-01-01 至 2018-12-31
来源：
https://researchdata.edu.au/characterising-an-important-coa-reductase/454833
关键词：
Characterisingimportantcontrolpointcholesterol

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英文摘要
The statins are the ‘go-to’ drugs for treating heart disease; blocking a very early, highly-controlled step in the pathway producing cholesterol. However, they inhibit the production of other vital molecules which explains why some patients do not tolerate them. We have identified that a later enzyme in this pathway is also highly controlled and here aim to characterise the molecular mechanisms involved. This work could translate into the development of even safer drugs for treating cholesterol-related diseases.
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Lipid trafficking at membrane contact sites: the role of Oxysterol-Binding Protein-Related Protein 5 and 8 (ORP5 and ORP8)
  • 批准号：
    nhmrc : 1141939
  • 项目类别：
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  • 资助金额：
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  • 财政年份：
    2018
  • 负责人：
    Prof Andrew Brown
  • 依托单位：
    The University of New South Wales
The role of adipose tissue cholesterol in metabolic diseases
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    nhmrc : 1141938
  • 项目类别：
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    $60.06万
  • 财政年份：
    2018
  • 负责人：
    Prof Andrew Brown
  • 依托单位：
    The University of New South Wales
Lipid trafficking at membrane contact sites: the role of Oxysterol-Binding Protein-Related Protein 5 and 8 (ORP5 and ORP8)
  • 批准号：
    nhmrc : GNT1141939
  • 项目类别：
    Project Grants
  • 资助金额：
    $46.64万
  • 财政年份：
    2018
  • 负责人：
    Prof Andrew Brown
  • 依托单位：
The role of adipose tissue cholesterol in metabolic diseases
  • 批准号：
    nhmrc : GNT1141938
  • 项目类别：
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  • 资助金额：
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  • 财政年份：
    2018
  • 负责人：
    Prof Andrew Brown
  • 依托单位：
海外基金