Characterising an important control point in cholesterol synthesis beyond HMG-CoA reductase

表征 HMG-CoA 还原酶之外的胆固醇合成的重要控制点

• 批准号: nhmrc : 1060515
• 负责人: Prof Andrew Brown
• 金额: $ 32.06万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-an-important-coa-reductase/454833
• 关键词: Characterising; important; control; point; cholesterol

The statins are the ‘go-to’ drugs for treating heart disease; blocking a very early, highly-controlled step in the pathway producing cholesterol. However, they inhibit the production of other vital molecules which explains why some patients do not tolerate them. We have identified that a later enzyme in this pathway is also highly controlled and here aim to characterise the molecular mechanisms involved. This work could translate into the development of even safer drugs for treating cholesterol-related diseases.

他汀类药物是治疗心脏病的“首选”药物;阻断产生胆固醇的途径中非常早期、高度受控的步骤。然而，它们抑制其他重要分子的产生，这解释了为什么有些患者不能耐受它们。我们已经确定，在这一途径中的后期酶也是高度受控的，这里的目的是阐明所涉及的分子机制。这项工作可以转化为治疗胆固醇相关疾病的更安全药物的开发。