Exploratory Analysis of RR and MBSR for Stress Reduction

摘要 在美国各地的医疗机构中有300多个独立的减压项目， 世界是仿照赫伯特本森的松弛反应（RR）计划或 正念减压（Mindfulness-Based Stress Reduction，MBSR）是由Jon Kabat-Zinn开发的一种减压方法。虽然两 治疗是基于冥想，科学哲学和冥想的传统， 每一个都是不同的，这些差异反映在指令和练习中。 教给病人。有相当多的公开发表的证据支持每一个程序的有效性 我们的初步数据表明，每种干预措施可能与不同的 行动机制。我们的功能性核磁共振成像数据表明，每种冥想方式都与 在区域激活方面存在统计学显著差异;此外，每种形式的冥想都是 与呼吸变化的不同模式和幅度相关。 这是第一次与每个干预的创始机构和马蒂诺的合作 MGH生物医学成像中心。在这项试点研究中，功能性MRI将与 用于确定放松反应的深度和正念变化的行为测量 评估RR和MBSR的特定神经、生理和心理结局 干预措施。从这些研究中获得的数据将提供第一个直接证据， 这两种流行的减压干预措施之间的作用机制。这些目标在 根据NCCAM的规定，研究的资助重点是为了阐明 有效的补充和替代医学实践的作用机制。 我们将对60名自我报告有亚临床心理困扰的成年人进行临床试验。 受试者将随机接受RR（n=30）或MBSR（n=30）计划。前后 接受其中一种干预后，所有受试者将参加GCRC的数据收集会议， 核磁共振扫描仪和完整的心理问卷。维持临床结局将是 在3个月随访时间点进行评估。

Abstract More than 300 independent stress reduction programs in medical facilities throughout the US and the world are modeled on either Herbert Benson's Relaxation Response (RR) program or the Mindfulness-Based Stress Reduction (MBSR) program developed by Jon Kabat-Zinn. Although both treatments are based on meditation, the scientific philosophies and meditative traditions upon which each is founded are different and these differences are reflected in the instructions and exercises taught to patients. There is considerable published evidence supporting the efficacy of each program and our preliminary data suggests that each intervention may be associated with differential mechanisms of action. Our functional MRI data suggests that each style of meditation is associated with statistically significant differences in regional activation; furthermore each form of meditation is associated with a differential pattern and magnitude of respiratory change. This is a first-time collaboration with the founding institutions of each intervention and the Martinos Center for Biomedical Imaging at the MGH. In this pilot study, functional MRI will be combined with behavioral measures for determining the depth of the relaxation response and changes in mindfulness to evaluate specific neurological, physiological and psychological outcomes of the RR and MBSR interventions. The data gained from these studies will provide the first direct evidence of differential mechanisms of action between these two popular stress reduction interventions. These aims are in accordance with NCCAM's stated research priority for the funding of studies geared to elucidating mechanisms of action underlying efficacious complementary and alternative medical practices. We will conduct a clinical trial of 60 adults with self-reported sub-clinical psychological distress. Subjects will be randomized to receiving the RR (n=30) or MBSR (n=30) program. Before and after recieveing one of the interventions, all subjects will attend data collection sessions in the GCRC and MRI scanner, and complete psychological questionnaires. Maintenance of clinical outcome will be assessed at the three-month follow-up timepoint.