Exploratory Analysis of RR and MBSR for Stress Reduction

摘要 全美和美国各地医疗机构的300多个独立的压力缓解计划 世界是以赫伯特·本森的放松反应(RR)程序或 Jon Kabat-Zinn开发的基于正念的压力减轻(MBSR)计划。虽然两者都是 治疗是基于冥想、科学哲学和冥想传统 每个建立的都是不同的，这些差异反映在说明和练习中 传授给病人。有大量公开发表的证据支持每一种方案的有效性。 我们的初步数据表明，每一次干预都可能与差异有关 行动机制。我们的功能核磁共振数据表明，每种冥想方式都与 在统计上有显着的区域激活差异；此外，每种形式的冥想 与呼吸变化的不同模式和大小有关。 这是第一次与每个干预和马蒂诺的创始机构合作 麻省理工学院生物医学成像中心。在这项初步研究中，功能磁共振成像将与 确定放松反应深度和正念变化的行为测量 评估RR和MBSR的特定神经、生理和心理结果 干预措施。从这些研究中获得的数据将提供差异的第一个直接证据。 这两种流行的减压干预措施之间的作用机制。这些目标是在 根据NCCAM规定的研究优先顺序，资助旨在澄清的研究 有效的补充和替代医疗做法背后的作用机制。 我们将对60名自报亚临床心理障碍的成年人进行临床试验。 受试者将随机接受RR(n=30)或MBSR(n=30)计划。前前后后 接受其中一项干预后，所有受试者都将参加GCRC的数据收集会议，并 核磁共振扫描仪，并完成心理问卷。维护临床结果将是 在三个月的随访时间点进行评估。

Abstract More than 300 independent stress reduction programs in medical facilities throughout the US and the world are modeled on either Herbert Benson's Relaxation Response (RR) program or the Mindfulness-Based Stress Reduction (MBSR) program developed by Jon Kabat-Zinn. Although both treatments are based on meditation, the scientific philosophies and meditative traditions upon which each is founded are different and these differences are reflected in the instructions and exercises taught to patients. There is considerable published evidence supporting the efficacy of each program and our preliminary data suggests that each intervention may be associated with differential mechanisms of action. Our functional MRI data suggests that each style of meditation is associated with statistically significant differences in regional activation; furthermore each form of meditation is associated with a differential pattern and magnitude of respiratory change. This is a first-time collaboration with the founding institutions of each intervention and the Martinos Center for Biomedical Imaging at the MGH. In this pilot study, functional MRI will be combined with behavioral measures for determining the depth of the relaxation response and changes in mindfulness to evaluate specific neurological, physiological and psychological outcomes of the RR and MBSR interventions. The data gained from these studies will provide the first direct evidence of differential mechanisms of action between these two popular stress reduction interventions. These aims are in accordance with NCCAM's stated research priority for the funding of studies geared to elucidating mechanisms of action underlying efficacious complementary and alternative medical practices. We will conduct a clinical trial of 60 adults with self-reported sub-clinical psychological distress. Subjects will be randomized to receiving the RR (n=30) or MBSR (n=30) program. Before and after recieveing one of the interventions, all subjects will attend data collection sessions in the GCRC and MRI scanner, and complete psychological questionnaires. Maintenance of clinical outcome will be assessed at the three-month follow-up timepoint.