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Continuous Phoswich Detector for Molecular Imaging

用于分子成像的连续磷光探测器

基本信息

批准号：
7537072
负责人：
VIVEK V NAGARKAR
金额：
$ 18万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2010-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7537072
关键词：
Address Animals Area Arizona Biological Process Bite Cardiovascular system Collaborations Collimator Complex Data Data Analyses Deposition Depth Detection Development Devices Diagnosis Diagnostic radiologic examination Discipline of Nuclear Medicine Disease Disease model Evaluation Event Face Film Foundations Future Gamma Rays Goals Government Grant Growth Head Heart Heart Diseases Human Image Imaging Techniques Industry Ions Laboratory Animals Lanthanoid Series Elements Lead Letters Light Localized Malignant Neoplasms Measurement Measures Medical Imaging Methods Monitor Morphology Mus Noise Numbers Penetration Performance Persons Pharmaceutical Preparations Phase Photons Positron-Emission Tomography Process Property Protocols documentation Public Health Purpose Radial Radiation Radiation Monitoring Radioimmunoconjugate Radioisotopes Radiolabeled Rate Rattus Reporting Research Research Personnel Resolution Rewards Roentgen Rays Role Saints Salts Security Signal Transduction Source Staging Standards of Weights and Measures Structure System Techniques Technology Testing Therapeutic Intervention Thick Time Universities Vacuum Variant Width Work Writing X ray diffraction analysis X-Ray Computed Tomography X-Ray Diffraction absorption attenuation base cerous chloride concept cost cost effective data acquisition desire detector evaporation human disease improved in vivo instrumentation light emission molecular imaging monitoring device novel professor programs radiotracer reconstruction research study seal sensor single photon emission computed tomography thallium-doped sodium iodide tool tumor

项目摘要

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) imaging systems used in Nuclear Medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- interaction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them had significant performance limitations. The goal of the proposed Phase I research is to demonstrate the feasibility of developing a novel DOI scintillator in which the decay time of the light emission varies continuously with depth. The material processing techniques will be used to form a continuous phoswich detector, which will create a structure where the decay time of the light emission varies continuously with depth. Our approach is likely applicable to a number of new scintillators that are actively under development because of their superior properties, as well as to other scintillators known to show dramatic variations in decay times with dopant concentration. A number of most likely candidates will be initially investigated. Scintillator fabrication and initial characterization will be performed at RMD, and tests pertinent to molecular imaging will be performed at our collaborator's facilities at the University of Arizona. Molecular imaging techniques are well suited for imaging radiolabeled antibodies and other substances that can be used to localize and characterize tumors, and are well suited to the development of new radiolabeled agents for diagnosing and treating diseases in humans. The development of this detector will significantly improve the resolution and sensitivity with which measurements can be made. In turn, this will encourage the development of superior drugs and technologies to diagnose, stage and treat to curtail the progression of and even cure certain cancers, diseases of the heart and disorders of the circulatory system. Outside medical imaging, the proposed development will have widespread applications in industrial radiography, nondestructive evaluations, homeland security, and advanced imaging systems. PUBLIC HEALTH RELEVANCE: Positron Emission Tomography (PET) imaging systems used in nuclear medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- interaction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them had significant performance limitations. The proposed research will demonstrate the feasibility of developing a novel DOI scintillator in which the decay time of the light emission varies continuously with depth. The successful completion of the research will lead to widespread applications in medical imaging, industrial radiography, nondestructive evaluations, homeland security, and advanced imaging systems.

描述（由申请人提供）：核医学中使用的正电子发射断层扫描（PET）成像系统可能会因视差效应（称为径向伸长）而损失空间分辨率。一个允许相互作用深度（DOI）测定的闪烁探测器将是一个重要的进步。以前曾尝试开发用于PET的DOI消除器，但所有这些都具有显著的性能限制。拟议的第一阶段研究的目标是证明开发一种新型DOI闪烁体的可行性，其中光发射的衰减时间随深度连续变化。材料处理技术将用于形成连续的phoswich探测器，这将创建一个结构，其中光发射的衰减时间随深度连续变化。我们的方法可能适用于一些新的衰减器，这些衰减器由于其上级特性而正在积极开发中，以及其他已知衰减时间随掺杂剂浓度而发生剧烈变化的衰减器。将对一些最有可能的候选人进行初步调查。闪烁体的制造和初步表征将在RMD进行，与分子成像相关的测试将在我们的合作者在亚利桑那大学的设施进行。分子成像技术非常适合于对放射性标记的抗体和可用于定位和表征肿瘤的其他物质进行成像，并且非常适合于开发用于诊断和治疗人类疾病的新的放射性标记剂。该探测器的研制将大大提高测量的分辨率和灵敏度。反过来，这将鼓励开发用于诊断、分期和治疗的上级药物和技术，以遏制甚至治愈某些癌症、心脏病和循环系统疾病。在医学成像之外，拟议的发展将在工业射线照相、无损评估、国土安全和先进成像系统中得到广泛应用。公共卫生相关性：用于核医学的正电子发射断层扫描（PET）成像系统可能由于视差效应（称为径向伸长）而遭受空间分辨率损失。一个允许相互作用深度（DOI）测定的闪烁探测器将是一个重要的进步。以前曾尝试开发用于PET的DOI消除器，但所有这些都具有显著的性能限制。该研究将证明开发一种新型DOI闪烁体的可行性，其中光发射的衰减时间随深度连续变化。该研究的成功完成将导致在医学成像，工业射线照相，无损评估，国土安全和先进成像系统中的广泛应用。