Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT

用于平板锥形束 CT 中骨微结构成像的新型高分辨率闪烁体

基本信息

  • 批准号:
    9555332
  • 负责人:
  • 金额:
    $ 21.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-06-01 至 2019-08-31
  • 项目状态:
    已结题

项目摘要

Abstract Pathological changes in bone microarchitecture are associated with a broad range of musculoskeletal (MSK) diseases, including osteoporosis (OP) and osteoarthritis (OA). OP and OA carry significant healthcare burden, with an estimated 10 million US adults suffering from OP and 27 million afflicted by OA. This motivates quantitative assessment of bone microstructure on clinical imaging systems. Quantitative metrics of bone microarchitecture remain, however, underutilized in OP and OA because of limited spatial resolution of current orthopedic imaging modalities. Application of extremity CBCT in quantitative imaging of bone microstructure is likely to have high impact in OA and OP because (a) OA occurs primarily in the extremities, and (b) in OP, morphological measurements in distal extremities were shown to be indicative of fracture risk, including of hip fractures. Again, the spatial resolution of current extremity CBCT (≥0.25 mm) is insufficient to fully resolve the ≤0.1 mm trabeculae, limiting the performance in assessment of bone quality. We intend to address this specific issue through the development of a novel sensor that promises to provide the necessary resolution without compromising detector sensitivity. Efficacy of such a detector will be demonstrated through CBCT scanning and comparing results to those obtained using the current state-of-the-art system.
摘要 骨微结构的病理变化与广泛的骨损伤相关。 肌肉骨骼(MSK)疾病,包括骨质疏松症(OP)和骨关节炎(OA)。OP和OA进位 严重的医疗保健负担,估计有1000万美国成年人患有OP,2700万人患有OP。 患有OA这促使定量评估骨显微结构的临床成像 系统.然而,骨微结构的定量指标在OP和OA中仍未得到充分利用 这是因为当前矫形成像模态的有限空间分辨率。四肢的应用 CBCT在骨显微结构定量成像中可能对OA和OP具有很高的影响, (a)OA主要发生在四肢,和(B)在OP中,远端四肢的形态学测量 表明有骨折风险,包括髋部骨折。再次,空间分辨率 当前肢体CBCT(≥0.25 mm)不足以完全分辨≤0.1 mm的骨小梁,限制了 评估骨质量的性能。我们打算通过 开发一种新的传感器,承诺提供必要的分辨率,而不损害 探测器灵敏度这种探测器的有效性将通过CBCT扫描证明, 将结果与使用当前最先进的系统获得的结果进行比较。

项目成果

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VIVEK V NAGARKAR其他文献

VIVEK V NAGARKAR的其他文献

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{{ truncateString('VIVEK V NAGARKAR', 18)}}的其他基金

Dual Mode, Hand-held Intraoperative Imager
双模式手持式术中成像仪
  • 批准号:
    8455692
  • 财政年份:
    2012
  • 资助金额:
    $ 21.68万
  • 项目类别:
Dual Mode, Hand-held Intraoperative Imager
双模式手持式术中成像仪
  • 批准号:
    8551648
  • 财政年份:
    2012
  • 资助金额:
    $ 21.68万
  • 项目类别:
New Design of a Sensor for Ultrahigh Performance SPECT Imaging
用于超高性能 SPECT 成像的传感器的新设计
  • 批准号:
    7800158
  • 财政年份:
    2010
  • 资助金额:
    $ 21.68万
  • 项目类别:
New Design of a Photon Counting Detector for Breast CT
乳腺CT光子计数探测器的新设计
  • 批准号:
    7669824
  • 财政年份:
    2009
  • 资助金额:
    $ 21.68万
  • 项目类别:
Tunable Wavelength, High Efficiency Scintillator for Neutron Crystallography
用于中子晶体学的可调谐波长、高效闪烁体
  • 批准号:
    7746047
  • 财政年份:
    2009
  • 资助金额:
    $ 21.68万
  • 项目类别:
Low Cost High Frame Rate Detector for Macromolecular Diffraction and Scattering
用于大分子衍射和散射的低成本高帧率探测器
  • 批准号:
    7744537
  • 财政年份:
    2009
  • 资助金额:
    $ 21.68万
  • 项目类别:
Continuous Phoswich Detector for Molecular Imaging
用于分子成像的连续磷光探测器
  • 批准号:
    7537072
  • 财政年份:
    2008
  • 资助金额:
    $ 21.68万
  • 项目类别:
Reduced Afterglow Scintillator Films for High Speed Medical Imaging
用于高速医学成像的减少余辉闪烁体薄膜
  • 批准号:
    7537767
  • 财政年份:
    2008
  • 资助金额:
    $ 21.68万
  • 项目类别:
Reduced Afterglow Scintillator Films for High Speed Medical Imaging
用于高速医学成像的减少余辉闪烁体薄膜
  • 批准号:
    7932004
  • 财政年份:
    2008
  • 资助金额:
    $ 21.68万
  • 项目类别:
Reduced Afterglow Scintillator Films for High Speed Medical Imaging
用于高速医学成像的减少余辉闪烁体薄膜
  • 批准号:
    7688127
  • 财政年份:
    2008
  • 资助金额:
    $ 21.68万
  • 项目类别:

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