NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 7958413
• 负责人: STEVEN G. KOHAMA
• 金额: $ 32.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958413
• 关键词: 17 year old; Aging; Animals; Archives; Biological; Biological Models; Breeding; Collection; Computer Retrieval of Information on Scientific Projects Database; Disease; District of Columbia; Drug or chemical Tissue Distribution; Enrollment; Ensure; Equilibrium; Female; Funding; Future; Goals; Grant; Head; Human; Institutes; Institution; Macaca mulatta; Mails; Maintenance; National Institute on Aging; Neurosciences; Paper; Persons; Primates; Reporting; Research; Research Personnel; Research Project Grants; Resource Development; Resources; Role; Scientist; Societies; Source; Specimen; Telephone; United States National Institutes of Health; animal colony; animal resource; meetings; middle age; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are all Indian-derived, rhesus macaques with the majority being females, reflecting harem breeding practices. Management of the colony balances prognostication for immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. This is accomplished by interfacing with investigators and animal colony manager in the Division of Animal Resources. Overall colony issues are discussed through the Animal Utilization Committee. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. National concerns are coordinated through the Head of the NIA Office of Biological Resources and Resource Development, Dr. Nancy Nadon, either in person (Society for Neuroscience, 2008, Washington DC) and by phone calls and e-mail. A discussion with investigators outside of ONPRC, who also conduct aging research in nonhuman primates, was held at the AGE meeting held in Boulder, CO in 2008. Another role of the Aging Resource is the collection, archiving and distribution of tissue to scientists both locally and nationally (eg- see paper in press).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 国家老龄化研究所（NIA）为ONPRC的100只老年（17岁以上）非人灵长类动物提供每日生活费支持，称为灵长类动物衰老研究（PAS）。 PAS群体的目标是为研究人员提供一个模型系统，以探索人类衰老和疾病的潜在机制。这些动物都是来自印度的恒河猴，大多数是雌性，反映了后宫繁殖的做法。 殖民地的管理平衡了研究项目中的短期使用，并通过跟踪和招募中年候选人（如有必要）来确保持续更换。 这是通过与动物资源部的研究者和动物群经理进行沟通来完成的。 通过动物利用委员会讨论总体群体问题。 PAS管理的其他方面还包括收集、存档和分发被淘汰动物的组织标本，向NIA报告PAS的使用情况，并向NIA提供关于研究中使用老龄灵长类动物问题的意见。 通过NIA生物资源和资源开发办公室负责人Nancy Nadon博士亲自（神经科学学会，2008年，华盛顿DC）或通过电话和电子邮件协调国家关注的问题。 2008年在科罗拉多州博尔德举行的AGE会议上，与ONPRC以外的研究人员进行了讨论，他们也在非人类灵长类动物中进行衰老研究。 老龄化资源的另一个作用是收集、存档和分发组织给当地和全国的科学家（例如-见出版中的论文）。