NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 7958413
• 负责人: STEVEN G. KOHAMA
• 金额: $ 32.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958413
• 关键词: 17 year old; Aging; Animals; Archives; Biological; Biological Models; Breeding; Collection; Computer Retrieval of Information on Scientific Projects Database; Disease; District of Columbia; Drug or chemical Tissue Distribution; Enrollment; Ensure; Equilibrium; Female; Funding; Future; Goals; Grant; Head; Human; Institutes; Institution; Macaca mulatta; Mails; Maintenance; National Institute on Aging; Neurosciences; Paper; Persons; Primates; Reporting; Research; Research Personnel; Research Project Grants; Resource Development; Resources; Role; Scientist; Societies; Source; Specimen; Telephone; United States National Institutes of Health; animal colony; animal resource; meetings; middle age; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are all Indian-derived, rhesus macaques with the majority being females, reflecting harem breeding practices. Management of the colony balances prognostication for immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. This is accomplished by interfacing with investigators and animal colony manager in the Division of Animal Resources. Overall colony issues are discussed through the Animal Utilization Committee. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. National concerns are coordinated through the Head of the NIA Office of Biological Resources and Resource Development, Dr. Nancy Nadon, either in person (Society for Neuroscience, 2008, Washington DC) and by phone calls and e-mail. A discussion with investigators outside of ONPRC, who also conduct aging research in nonhuman primates, was held at the AGE meeting held in Boulder, CO in 2008. Another role of the Aging Resource is the collection, archiving and distribution of tissue to scientists both locally and nationally (eg- see paper in press).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 美国国家老化研究所（NIA）为ONPRC的100岁（17岁以上）非人类灵长类动物的殖民地提供了DIEM支持，称为灵长类动物衰老研究（PAS）。 PAS菌落的目的是为研究人员提供模型系统，以探索人类衰老和疾病的基础机制。这些动物都是印度衍生的，恒河猕猴，大多数是女性，反映了后宫繁殖的做法。 殖民地的管理平衡预测，以在研究项目中立即使用，并在必要时通过跟踪和注册中年候选人来确保持续替代。 这是通过与调查人员和动物殖民地经理接触动物资源部门来实现的。 整体殖民地问题将通过动物利用委员会讨论。 PAS管理的其他方面还包括收集，归档和分布从被淘汰动物的组织标本，向NIA报告PAS使用情况，并向NIA投入研究中的灵长类动物利用率问题。 NIA生物资源与资源开发办公室主管Nancy Nadon博士（神经科学协会，2008年，华盛顿特区）以及通过电话和电子邮件进行了协调。 与ONPRC之外的研究人员的讨论也在2008年在科罗拉多州博尔德举行的年龄会议上进行。衰老资源的另一个作用是在本地和全国范围内将组织的收集，归档和分配给科学家（例如，请参见《印刷中的论文》）。