NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 7715876
• 负责人: STEVEN G. KOHAMA
• 金额: $ 32.35万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715876
• 关键词: 17 year old; Age; Aging; Animals; Archives; Autopsy; Biological Markers; Biological Models; Breeding; Cognitive aging; Collection; Computer Retrieval of Information on Scientific Projects Database; Databases; Disease; Drug or chemical Tissue Distribution; Enrollment; Female; Funding; Future; Gender; Goals; Grant; Human; Individual; Institutes; Institution; Macaca mulatta; Maintenance; Menopause; Phenotype; Primates; Reporting; Research; Research Personnel; Resources; Sampling; Scientist; Source; Specimen; Tissue Banks; Tissues; United States National Institutes of Health; aged; animal resource; endometriosis; genetic pedigree; middle age; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. Individual animals are all Indian-derived, rhesus monkeys, with a gender ratio currently favoring females, reflecting harem breeding practices. Management includes: 1. Identification and tracking of middle-aged candidates for future enrollment; 2. Identification of animals with desirable phenotypes by scientists from all Divisions (the User's Group); 3. Coordination with the colony manager (Dr. Bland) of the Division of Animal Resources; and 4. Overall colony issues are discussed through the Animal Utilization Committee. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. For the latter, meetings have been held that deal with primate aging and biomarkers, menopause, endometriosis and cognitive aging. We also support the NIA Primate Aging Database (at WNPRC), and Tissue Bank (BioReliance). Tissue from aged animals has been distributed right from necropsy or from archives, to scientists internal and external to ONPRC. For example, archived samples were very useful for retrospective pedigree analysis of animals at the Center, since many of the aged animals were a part of the original Founder group.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 国家老龄研究所(NIA)为ONPRC的100名老年(17岁以上)非人类灵长类动物提供每日支持，该群体被称为灵长类衰老研究(PAS)。PAS群体的目标是为研究人员提供一个模型系统，在其中探索人类衰老和疾病的潜在机制。个体动物都是来自印度的恒河猴，目前的性别比例倾向于雌性，这反映了后宫繁殖的做法。管理包括：1.识别和跟踪未来登记的中年候选人；2.所有部门(用户组)的科学家识别具有理想表型的动物；3.与动物资源部的群体经理(Bland博士)协调；4.通过动物利用委员会讨论整体群体问题。 PAS管理的其他方面还包括收集、存档和分发被扑杀的动物的组织标本，向NIA报告PAS的使用情况，并就研究中使用的老化灵长类动物问题向NIA提供意见。对于后者，已经召开了处理灵长类衰老和生物标记物、更年期、子宫内膜异位症和认知衰老的会议。我们还支持NIA灵长类老龄化数据库(在WNPRC)和组织银行(BioReliance)。来自老年动物的组织已经从尸检或档案中直接分发给了ONPRC内外的科学家。例如，存档的样本对该中心的动物追溯系谱分析非常有用，因为许多老年动物是原始创建者群体的一部分。