NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 8357739
• 负责人: STEVEN G. KOHAMA
• 金额: $ 28.15万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357739
• 关键词: 17 year old; Aging; Animals; Applications Grants; Archives; Biological Models; Collection; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Female; Funding; Future; Goals; Grant; Human; Institutes; Macaca mulatta; Maintenance; National Center for Research Resources; National Institute on Aging; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Source; Specimen; United States National Institutes of Health; animal resource; cost; male; middle age; nonhuman primate; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are Indian-derived, male and female rhesus macaques with management of the colony reflecting immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. Management issues are discussed with the Division of Animal Resources, the Animal Utilization Committee, as well as with the Aging Working Group. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. This resource is making good progress in the maintenance and allocation of animals as well as archival services. Several grant applications have been submitted in the past year to utilize these animals and scores reflect a fundable range for at least a couple of studies.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 美国国家老化研究所（NIA）为ONPRC的100岁（17岁以上）非人类灵长类动物的殖民地提供了DIEM支持，称为灵长类动物衰老研究（PAS）。 PAS菌落的目的是为研究人员提供模型系统，以探索人类衰老和疾病的基础机制。这些动物是印度衍生的，男性和女恒河猕猴的管理，并管理着殖民地的管理，反映了未来在研究项目中的使用，并通过跟踪和招募中年候选人的持续替代。 管理问题与动物资源部，动物利用委员会以及老龄化工作组讨论。 PAS管理的其他方面还包括收集，归档和分布从被淘汰动物的组织标本，向NIA报告PAS使用情况，并向NIA投入研究中的灵长类动物利用率问题。该资源在动物的维护和分配以及档案服务方面取得了良好的进步。 在过去的一年中，已经提交了几项赠款申请，以利用这些动物，而得分反映了至少一些研究的资金范围。