NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 8357739
• 负责人: STEVEN G. KOHAMA
• 金额: $ 28.15万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357739
• 关键词: 17 year old; Aging; Animals; Applications Grants; Archives; Biological Models; Collection; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Female; Funding; Future; Goals; Grant; Human; Institutes; Macaca mulatta; Maintenance; National Center for Research Resources; National Institute on Aging; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Source; Specimen; United States National Institutes of Health; animal resource; cost; male; middle age; nonhuman primate; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are Indian-derived, male and female rhesus macaques with management of the colony reflecting immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. Management issues are discussed with the Division of Animal Resources, the Animal Utilization Committee, as well as with the Aging Working Group. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. This resource is making good progress in the maintenance and allocation of animals as well as archival services. Several grant applications have been submitted in the past year to utilize these animals and scores reflect a fundable range for at least a couple of studies.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 国家老龄研究所(NIA)为ONPRC的100名老年(17岁以上)非人类灵长类动物提供每日支持，该群体被称为灵长类衰老研究(PAS)。PAS群体的目标是为研究人员提供一个模型系统，在其中探索人类衰老和疾病的潜在机制。这些动物是来自印度的雄性和雌性恒河猴，它们对种群的管理反映了未来在研究项目中的即时使用，并在必要时通过跟踪和招募中年候选人来确保不断更换。与动物资源司、动物利用委员会以及老龄工作组讨论管理问题。PAS管理的其他方面还包括收集、存档和分发被扑杀的动物的组织标本，向NIA报告PAS的使用情况，并就研究中使用的老化灵长类动物问题向NIA提供意见。该资源在动物的维护和分配以及档案服务方面取得了良好的进展。在过去的一年里，已经提交了几份利用这些动物的拨款申请，分数反映了至少几项研究的资金范围。