NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

国家老龄化研究所 (NIA)：老龄化群体维护

• 批准号: 8173184
• 负责人: STEVEN G. KOHAMA
• 金额: $ 33.19万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173184
• 关键词: 17 year old; Age; Aging; Animals; Archives; Biological Models; Collection; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Female; Funding; Future; Goals; Grant; Human; Institutes; Institution; Macaca mulatta; Maintenance; National Institute on Aging; Primates; Reporting; Research; Research Personnel; Research Project Grants; Resources; Services; Source; Specimen; United States National Institutes of Health; animal resource; male; middle age; nonhuman primate; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are Indian-derived, male and female rhesus macaques with management of the colony reflecting immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. Management issues are discussedwith the Division of Animal Resources, the Animal Utilization Committee, as well as with the Aging Working Group. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. This resource is making good progress in the maintenance and allocation of animals as well as archival services.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 美国国家老化研究所（NIA）为ONPRC的100岁（17岁以上）非人类灵长类动物的殖民地提供了DIEM支持，称为灵长类动物衰老研究（PAS）。 PAS菌落的目的是为研究人员提供模型系统，以探索人类衰老和疾病的基础机制。这些动物是印度衍生的，男性和女恒河猕猴的管理，并管理着殖民地的管理，反映了未来在研究项目中的使用，并通过跟踪和招募中年候选人的持续替代。 与动物资源分工，动物利用委员会以及老龄化工作组讨论了管理问题。 PAS管理的其他方面还包括收集，归档和分布从被淘汰动物的组织标本，向NIA报告PAS使用情况，并向NIA投入研究中的灵长类动物利用率问题。该资源在动物的维护和分配以及档案服务方面取得了良好的进步。