NATIONAL INSTITUTE ON AGING (NIA): AGING COLONY MAINTENANCE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 国家老龄化研究所（NIA）为ONPRC的100只老年（17岁以上）非人灵长类动物提供每日生活费支持，称为灵长类动物衰老研究（PAS）。 PAS群体的目标是为研究人员提供一个模型系统，以探索人类衰老和疾病的潜在机制。这些动物是源自印度的雄性和雌性恒河猴，对殖民地的管理反映了研究项目的近期使用，并确保通过跟踪和招募中年候选人（如有必要）进行持续替换。 管理问题与动物资源司、动物利用委员会以及老龄化工作组讨论。 PAS管理的其他方面还包括收集、存档和分发被淘汰动物的组织标本，向NIA报告PAS的使用情况，并向NIA提供关于研究中使用老龄灵长类动物问题的意见。这一资源在动物的维护和分配以及档案服务方面取得了良好的进展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of Aging (NIA) provides per diem support for a colony of 100 aged (17+ years old) nonhuman primates at ONPRC called the Primate Aging Study (PAS). The goal of the PAS colony is to provide investigators with a model system in which to explore mechanisms underlying human aging and disease. The animals are Indian-derived, male and female rhesus macaques with management of the colony reflecting immediate future use in research projects and ensuring continual replacement by tracking and enrolling middle-aged candidates, as necessary. Management issues are discussedwith the Division of Animal Resources, the Animal Utilization Committee, as well as with the Aging Working Group. Other aspects of PAS management also include the collection, archiving and distribution of tissue specimens from culled animals, reports to the NIA on PAS usage and input to the NIA on issues of aging primate utilization in research. This resource is making good progress in the maintenance and allocation of animals as well as archival services.