CHARACTERIZATION OF NHPS DISPLAYING PHENOTYPES OF HUMAN DISEASES

显示人类疾病表型的 NHPS 特征

• 批准号: 7957962
• 负责人: Anthony G. Comuzzie
• 金额: $ 0.08万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957962
• 关键词: Adult; Animal Model; Animals; Blood; Body Weights and Measures; Chronic; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Data; Diabetes Mellitus; Disease; Environment; Fatty acid glycerol esters; Female; Funding; Genetic; Glucose; Grant; Human; Institution; Lead; Lipids; Macaca mulatta; Measures; Metabolic; Metabolic Diseases; Natural History; Obesity; Phenotype; Physiological; Primate Diseases; Primates; Public Health; Research; Research Personnel; Resources; Risk; Sampling; Solid; Source; United States National Institutes of Health; Urine; Variant; cohort; comparative; human disease; nonhuman primate; therapy development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Metabolically related diseases such as obesity, diabetes, and coronary heart disease represent major threats to public health in the modern environment. The establishment of solid animal models, such as non-human primates, of these diseases is paramount in furthering our understanding of their triggers and natural history of these conditions. Ultimately this increased understnding should lead to the development of interventions or preventions for these common human diseases. Because of its genetic and physiological similarity to humans, the rhesus macaque is an ideal animal for such studies. For the current study we will collect a single blood and urine sample along with measures of body weight, and fat distribution from a cohort of 40 adult female rhesus monkeys. We will use the blood and urine samples to measure basic parameters such as glucose and lipid levels. The data generated from the present study will be pooled with similar data collected from other colonies of rhesus monkeys in order to generate basic comparative data on variation in these important metabolic parameters which are know to be associated with risk for a variety of chronic metabolic diseases in humans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 肥胖、糖尿病和冠心病等代谢相关疾病是现代环境中公共健康的主要威胁。建立这些疾病的实体动物模型（例如非人类灵长类动物）对于进一步了解这些疾病的诱因和自然史至关重要。 最终，这种了解的加深应该会导致针对这些常见人类疾病的干预措施或预防措施的发展。 由于恒河猴的遗传和生理学与人类相似，因此它是此类研究的理想动物。 在当前的研究中，我们将从 40 只成年雌性恒河猴中采集一份血液和尿液样本，并测量体重和脂肪分布。 我们将使用血液和尿液样本来测量基本参数，例如血糖和血脂水平。 本研究产生的数据将与从其他恒河猴群体收集的类似数据汇总，以生成这些重要代谢参数变化的基本比较数据，这些参数已知与人类多种慢性代谢疾病的风险相关。