BASAL HEPATIC GLUCOSE AND INSULIN SENSITIVITY IN BABOONS

狒狒的基础肝葡萄糖和胰岛素敏感性

• 批准号: 7562448
• 负责人: Anthony G. Comuzzie
• 金额: $ 1.29万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562448
• 关键词: Animals; Computer Retrieval of Information on Scientific Projects Database; Fatty acid glycerol esters; Funding; Gene Expression; Glucose; Gold; Grant; Hepatic; Infusion procedures; Institution; Insulin; Longitudinal Studies; Measures; Molecular Genetics; Muscle; Obesity; Papio; Pattern; Procedures; Protocols documentation; Purpose; Research; Research Personnel; Resources; Source; Standards of Weights and Measures; Techniques; Tissues; United States National Institutes of Health; diabetic; glucose metabolism; human subject; insulin sensitivity; insulin signaling; liver biopsy; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study was to conduct assessments of glucose metabolism by performing the euglycemic-hyperinsulinemic clamp procedure in baboons in order to compare the difference in glucose clearance between obese, lean, and diabetic animals. The euglycemic- hyperinsulinemic clamp procedure is considered the "Gold Standard" technique to measure insulin sensitivity, and is routinely performed in human subjects, and will allow us to evaluate insulin sensitivity in these animals. During the euglycemic-hyperinsulinemic clamp procedure circulating glucose is held constant by infusion of exogenous glucose in response to rising insulin levels. As part of this project we have also collected muscle, fat and liver biopsies while under insulin administration to examine tissue-specific differences in glucose utilization, insulin signaling, and gene expression patterns. Our major objective is to validate this protocol for long term studies in molecular genetics of the insulin-glucose axis.

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