BASAL HEPATIC GLUCOSE AND INSULIN SENSITIVITY IN BABOONS

狒狒的基础肝葡萄糖和胰岛素敏感性

基本信息

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study was to conduct assessments of glucose metabolism by performing the euglycemic-hyperinsulinemic clamp procedure in baboons in order to compare the difference in glucose clearance between obese, lean, and diabetic animals. The euglycemic- hyperinsulinemic clamp procedure is considered the "Gold Standard" technique to measure insulin sensitivity, and is routinely performed in human subjects, and will allow us to evaluate insulin sensitivity in these animals. During the euglycemic-hyperinsulinemic clamp procedure circulating glucose is held constant by infusion of exogenous glucose in response to rising insulin levels. As part of this project we have also collected muscle, fat and liver biopsies while under insulin administration to examine tissue-specific differences in glucose utilization, insulin signaling, and gene expression patterns. Our major objective is to validate this protocol for long term studies in molecular genetics of the insulin-glucose axis.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Anthony G. Comuzzie其他文献

ENTENDIENDO LAS CAUSAS DE LA OBESIDAD A TRAVÉS DE LA BIOLOGÍA CELULAR DEL ADIPOCITO. Revisión
ENTENDIENDO LAS CAUSAS DE LA OBESIDAD A TRAVÉS DE LA BIOLOGÍA CELULAR DEL ADIPOCITO。
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Raul A. Bastarrachea;Ramón E. Fuenmayor;I. Brajkovich;Anthony G. Comuzzie
  • 通讯作者:
    Anthony G. Comuzzie
Heritability of Ambulatory and Beat-to-Beat Office Blood Pressure in Large Multigenerational Arab Pedigrees: The ‘Oman Family Study’
大型多代阿拉伯谱系中动态血压和逐次搏动办公室血压的遗传性:“阿曼家庭研究”
  • DOI:
    10.1017/thg.2012.59
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0.9
  • 作者:
    S. Albarwani;M. Munoz;V. S. Voruganti;D. Jaju;V. Saeed Al;S. Rizvi;J. López;Zahir M Al;R. Bayoumi;Anthony G. Comuzzie;H. Snieder;M. Hassan
  • 通讯作者:
    M. Hassan
Genómica de la regulación del peso corporal: mecanismos moleculares que predisponen a la obesidad
Genómica de la regulación del peso corporal: mecanismos moleculares que predisponen a la obesidad
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Raul A. Bastarrachea;Shelley A. Cole;Anthony G. Comuzzie
  • 通讯作者:
    Anthony G. Comuzzie
A Family Study in Oman: Large, Consanguineous, Polygamous Omani Arab Pedigrees
阿曼的家庭研究:庞大、近亲、一夫多妻制的阿曼阿拉伯血统
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    M. Hassan;S. Albarwani;S. A. Yahyaee;S. A. Haddabi;S. Rizwi;A. Jaffer;J. Al;G. Cai;Anthony G. Comuzzie;R. Bayoumi
  • 通讯作者:
    R. Bayoumi
Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects
瘦、超重和肥胖受试者对精神和身体压力的血流动力学和自主反应
  • DOI:
    10.15744/2455-7633.2.105
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    D. Jaju;M. Alabri;Hassan Mo;Alvarenga Jl;Anthony G. Comuzzie;S. Albarwani;S. AlYahyee;R. Bayoumi;K. Alhashmi
  • 通讯作者:
    K. Alhashmi

Anthony G. Comuzzie的其他文献

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{{ truncateString('Anthony G. Comuzzie', 18)}}的其他基金

FASEB SRC on From Causes to Consequences, to Treatment: Obesity in Perspective
FASEB SRC 探讨从原因到后果,再到治疗:肥胖的视角
  • 批准号:
    8400279
  • 财政年份:
    2012
  • 资助金额:
    $ 1.29万
  • 项目类别:
IDENTIFYING GENES FOR OBESITY QTLS RELATED TO CVD
识别与 CVD 相关的肥胖 QTLS 基因
  • 批准号:
    8357655
  • 财政年份:
    2011
  • 资助金额:
    $ 1.29万
  • 项目类别:
IDENTIFYING GENES FOR OBESITY QTLS RELATED TO CVD
识别与 CVD 相关的肥胖 QTLS 基因
  • 批准号:
    8172661
  • 财政年份:
    2010
  • 资助金额:
    $ 1.29万
  • 项目类别:
IDENTIFICATION OF OBESITY-RELATED QTLs
肥胖相关 QTL 的鉴定
  • 批准号:
    8147524
  • 财政年份:
    2010
  • 资助金额:
    $ 1.29万
  • 项目类别:
Identifying Genes for Obesity QTLs Related to CVD
识别与 CVD 相关的肥胖 QTL 基因
  • 批准号:
    8147442
  • 财政年份:
    2010
  • 资助金额:
    $ 1.29万
  • 项目类别:
GASTROINTESTINAL PEPTIDES IN GLUCOSE REGULATION
胃肠肽在血糖调节中的作用
  • 批准号:
    7957924
  • 财政年份:
    2009
  • 资助金额:
    $ 1.29万
  • 项目类别:
CHARACTERIZATION OF NHPS DISPLAYING PHENOTYPES OF HUMAN DISEASES
显示人类疾病表型的 NHPS 特征
  • 批准号:
    7957962
  • 财政年份:
    2009
  • 资助金额:
    $ 1.29万
  • 项目类别:
PLEIOTROPIC EFFECTS ON OBESITY AND LIPOPROTEINS
对肥胖和脂蛋白的多效作用
  • 批准号:
    7716119
  • 财政年份:
    2008
  • 资助金额:
    $ 1.29万
  • 项目类别:
Identification of Obesity-Related QTLs
肥胖相关 QTL 的鉴定
  • 批准号:
    7470230
  • 财政年份:
    2008
  • 资助金额:
    $ 1.29万
  • 项目类别:
GASTROINTESTINAL PEPTIDES IN GLUCOSE REGULATION
胃肠肽在血糖调节中的作用
  • 批准号:
    7716149
  • 财政年份:
    2008
  • 资助金额:
    $ 1.29万
  • 项目类别:
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