BASAL HEPATIC GLUCOSE AND INSULIN SENSITIVITY IN BABOONS

狒狒的基础肝葡萄糖和胰岛素敏感性

• 批准号: 7562448
• 负责人: Anthony G. Comuzzie
• 金额: $ 1.29万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562448
• 关键词: Animals; Computer Retrieval of Information on Scientific Projects Database; Fatty acid glycerol esters; Funding; Gene Expression; Glucose; Gold; Grant; Hepatic; Infusion procedures; Institution; Insulin; Longitudinal Studies; Measures; Molecular Genetics; Muscle; Obesity; Papio; Pattern; Procedures; Protocols documentation; Purpose; Research; Research Personnel; Resources; Source; Standards of Weights and Measures; Techniques; Tissues; United States National Institutes of Health; diabetic; glucose metabolism; human subject; insulin sensitivity; insulin signaling; liver biopsy; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study was to conduct assessments of glucose metabolism by performing the euglycemic-hyperinsulinemic clamp procedure in baboons in order to compare the difference in glucose clearance between obese, lean, and diabetic animals. The euglycemic- hyperinsulinemic clamp procedure is considered the "Gold Standard" technique to measure insulin sensitivity, and is routinely performed in human subjects, and will allow us to evaluate insulin sensitivity in these animals. During the euglycemic-hyperinsulinemic clamp procedure circulating glucose is held constant by infusion of exogenous glucose in response to rising insulin levels. As part of this project we have also collected muscle, fat and liver biopsies while under insulin administration to examine tissue-specific differences in glucose utilization, insulin signaling, and gene expression patterns. Our major objective is to validate this protocol for long term studies in molecular genetics of the insulin-glucose axis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是通过在狒狒中执行伯糖囊纤维蛋白酶夹程序进行评估，以比较肥胖，瘦肉和糖尿病动物之间的葡萄糖清除率差异。 毛囊高胰岛素夹程序被认为是测量胰岛素敏感性的“黄金标准”技术，并在人类受试者中通常进行，并且将使我们能够评估这些动物中的胰岛素敏感性。 在尿糖血糖蛋白酶夹子过程中，循环葡萄糖通过响应胰岛素水平上升而持续循环葡萄糖。 作为该项目的一部分，我们还收集了胰岛素给药，以检查葡萄糖利用，胰岛素信号传导和基因表达模式的组织特异性差异。我们的主要目的是验证该方案以在胰岛素 - 葡萄糖轴的分子遗传学中进行长期研究。