FASEB SRC on From Causes to Consequences, to Treatment: Obesity in Perspective

FASEB SRC 探讨从原因到后果，再到治疗：肥胖的视角

• 批准号: 8400279
• 负责人: Anthony G. Comuzzie
• 金额: $ 1.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8400279
• 关键词: Academia; Address; Adipose tissue; Adult; Area; Basic Science; Behavior; Behavioral Genetics; Biological Factors; Body Weight; Clinical; Collaborations; Communities; Comorbidity; Complex; Deposition; Development; Environment; Environmental Risk Factor; Fostering; Genes; Heterogeneity; Individual; Industry; Investigation; Lead; Life Style; Lipids; Metabolic Diseases; Methods; Nature; Obesity; Overweight; Pattern; Physiology; Population; Prevalence; Prevention; Prevention program; Preventive; Process; Public Health; Public Policy; Regulation; Research; Research Design; Research Personnel; Risk; Scientist; Shapes; United States Dept. of Health and Human Services; Work; base; career development; design; effective therapy; falls; holistic approach; improved; meetings; obesity in children; obesity treatment; pre-clinical; success; symposium; treatment program

DESCRIPTION (provided by applicant): Among the adult population of the US it is now estimated that over 60 percent are overweight or obese, and the prevalence of childhood obesity is increasing at a staggering rate. The Department of Health and Human Services has ranked obesity among the most significant public health threats/burdens of the twenty-first century. To date efforts at prevention and treatment for obesity have met with mixed success, undoubtedly reflecting the underlying heterogeneity in its origin and expression. Therefore, given the multitude of factors impacting body weight regulation, patterns of lipid deposition, and adipose tissue function and their impact on metabolic and disease processes, it is critical for the field of obesity research to seek an integrative perspective in order to better understand the intricate interplay between genetics, behavior, and the external environment in order to identify the most productive avenues of treatment and prevention. While there are many conferences on obesity and its associated co-morbidities, few take such an integrative approach bringing together such topics in a vertically integrated format. In order to develop effective methods of prevention and treatment for obesity and its associated co-morbidities it is incumbent that we understand all aspects of the contributing factors, and their interactions, to the development of obesity. Therefore, the objective of the proposed conference is to provide an opportunity for researchers working on the various facets of obesity to interact and initiate a dialogue in an effort to encourage increased interaction and collaboration from a more integrated perspective. PROGRAM NARRATIVE: Among the adult population of the US it is now estimated that over 60 percent are overweight or obese, and the prevalence of childhood obesity is increasing at a staggering rate. The Department of Health and Human Services has ranked obesity among the most significant public health threats/burdens of the twenty-first century. To date efforts at prevention and treatment for obesity have met with mixed success, undoubtedly reflecting the underlying heterogeneity in its origin and expression. Therefore, given the multitude of factors impacting body weight regulation, patterns of lipid deposition, and adipose tissue function and their impact on metabolic and disease processes, it is critical for the field of obesity research t seek an integrative perspective in order to better understand the intricate interplay between genetics, behavior, and the external environment in order to identify the most productive avenues of treatment and prevention. While there are many conferences on obesity and its associated co-morbidities, few take such an integrative approach bringing together such topics in a vertically integrated format. In order to develop effective methods of prevention and treatment for obesity and its associated co-morbidities it is incumbent that we understand all aspects of the contributing factors, and their interactions, to the development of obesity. Therefore, the objective of the proposed conference is to provide an opportunity for researchers working on the various facets of obesity to interact and initiate a dialogue in an effort to encourage increased interaction and collaboration from a more integrated perspective.

描述（由申请人提供）：在美国的成年人口中，现在估计超过60％的超重或肥胖，儿童肥胖的患病率正在以惊人的速度增加。卫生和公共服务部已将肥胖症列为二十一世纪最重要的公共卫生威胁/负担。迄今为止，预防和肥胖治疗的努力取得了混乱的成功，无疑反映了其起源和表达的潜在异质性。因此，鉴于影响体重调节的多种因素，脂质沉积的模式以及脂肪组织功能及其对代谢和疾病过程的影响，这对于 肥胖研究领域要寻求综合观点，以便更好地了解遗传学，行为和外部环境之间的复杂相互作用，以确定最有生产力的治疗和预防途径。尽管关于肥胖及其相关的合并症有很多会议，但很少有人采用这种综合方法将这种主题汇总为垂直整合的格式。为了开发有效的预防和治疗方法及其相关的合并症，我们有责任了解肥胖发展的各个方面及其相互作用的各个方面。因此，拟议会议的目的是为从事肥胖的各个方面的研究人员提供一个机会，以互动和发起对话，以鼓励从更一体化的角度来鼓励增加互动和协作。 计划叙述：在美国的成年人口中，现在估计超过60％的超重或肥胖，儿童肥胖症的流行率正在以惊人的速度增加。卫生和公共服务部已将肥胖症列为二十一世纪最重要的公共卫生威胁/负担。迄今为止，预防和肥胖治疗的努力取得了混乱的成功，无疑反映了其起源和表达的潜在异质性。因此，鉴于影响体重调节的多种因素，脂质沉积的模式以及脂肪组织功能及其对代谢和疾病过程的影响，对于肥胖研究领域而言，它至关重要，以寻求综合的观点，以便更好地了解遗传学，行为和外部环境之间的复杂相互作用，以确定最有生产力的治疗和预测的外部环境。尽管关于肥胖及其相关的合并症有很多会议，但很少有人采用这种综合方法将这种主题汇总为垂直整合的格式。为了开发有效的预防和治疗方法及其相关的合并症，我们有责任了解肥胖发展的各个方面及其相互作用的各个方面。因此，拟议会议的目的是为从事肥胖的各个方面的研究人员提供一个机会，以互动和发起对话，以鼓励从更一体化的角度来鼓励增加互动和协作。