FASEB SRC on From Causes to Consequences, to Treatment: Obesity in Perspective

描述(申请人提供)：据估计，在美国成年人口中，超过60%的人超重或肥胖，儿童肥胖症的患病率正在以惊人的速度增长。卫生与公众服务部将肥胖症列为21世纪最严重的公共卫生威胁/负担之一。到目前为止，预防和治疗肥胖症的努力取得了好坏参半的结果，这无疑反映了肥胖症的起源和表达的潜在异质性。因此，考虑到影响体重调节、脂肪沉积模式和脂肪组织功能的多种因素及其对新陈代谢和疾病过程的影响，对于 为了更好地理解遗传、行为和外部环境之间错综复杂的相互作用，以确定最有效的治疗和预防途径，肥胖症研究领域寻求综合的视角。虽然有许多关于肥胖及其相关共病的会议，但很少有人采取这样一种综合的方法，将这些主题以垂直整合的形式聚集在一起。为了开发有效的预防和治疗肥胖症及其相关共病的方法，我们有责任了解肥胖症发展的各个方面的促成因素及其相互作用。因此，拟议会议的目标是为致力于肥胖各个方面的研究人员提供一个互动和发起对话的机会，以努力从更综合的角度鼓励更多的互动和合作。 节目简介：据估计，在美国成年人口中，超过60%的人超重或肥胖，儿童肥胖症的患病率正在以惊人的速度增长。卫生与公众服务部将肥胖症列为21世纪最严重的公共卫生威胁/负担之一。到目前为止，预防和治疗肥胖症的努力取得了好坏参半的结果，这无疑反映了肥胖症的起源和表达的潜在异质性。因此，考虑到影响体重调节、脂肪沉积模式和脂肪组织功能的多种因素及其对代谢和疾病过程的影响，肥胖症研究领域寻求综合视角以更好地了解遗传、行为和外部环境之间的复杂相互作用，以确定最有效的治疗和预防途径是至关重要的。虽然有许多关于肥胖及其相关共病的会议，但很少有人采取这样一种综合的方法，将这些主题以垂直整合的形式聚集在一起。为了开发有效的预防和治疗肥胖症及其相关共病的方法，我们有责任了解肥胖症发展的各个方面的促成因素及其相互作用。因此，拟议会议的目标是为致力于肥胖各个方面的研究人员提供一个互动和发起对话的机会，以努力从更综合的角度鼓励更多的互动和合作。

DESCRIPTION (provided by applicant): Among the adult population of the US it is now estimated that over 60 percent are overweight or obese, and the prevalence of childhood obesity is increasing at a staggering rate. The Department of Health and Human Services has ranked obesity among the most significant public health threats/burdens of the twenty-first century. To date efforts at prevention and treatment for obesity have met with mixed success, undoubtedly reflecting the underlying heterogeneity in its origin and expression. Therefore, given the multitude of factors impacting body weight regulation, patterns of lipid deposition, and adipose tissue function and their impact on metabolic and disease processes, it is critical for the field of obesity research to seek an integrative perspective in order to better understand the intricate interplay between genetics, behavior, and the external environment in order to identify the most productive avenues of treatment and prevention. While there are many conferences on obesity and its associated co-morbidities, few take such an integrative approach bringing together such topics in a vertically integrated format. In order to develop effective methods of prevention and treatment for obesity and its associated co-morbidities it is incumbent that we understand all aspects of the contributing factors, and their interactions, to the development of obesity. Therefore, the objective of the proposed conference is to provide an opportunity for researchers working on the various facets of obesity to interact and initiate a dialogue in an effort to encourage increased interaction and collaboration from a more integrated perspective. PROGRAM NARRATIVE: Among the adult population of the US it is now estimated that over 60 percent are overweight or obese, and the prevalence of childhood obesity is increasing at a staggering rate. The Department of Health and Human Services has ranked obesity among the most significant public health threats/burdens of the twenty-first century. To date efforts at prevention and treatment for obesity have met with mixed success, undoubtedly reflecting the underlying heterogeneity in its origin and expression. Therefore, given the multitude of factors impacting body weight regulation, patterns of lipid deposition, and adipose tissue function and their impact on metabolic and disease processes, it is critical for the field of obesity research t seek an integrative perspective in order to better understand the intricate interplay between genetics, behavior, and the external environment in order to identify the most productive avenues of treatment and prevention. While there are many conferences on obesity and its associated co-morbidities, few take such an integrative approach bringing together such topics in a vertically integrated format. In order to develop effective methods of prevention and treatment for obesity and its associated co-morbidities it is incumbent that we understand all aspects of the contributing factors, and their interactions, to the development of obesity. Therefore, the objective of the proposed conference is to provide an opportunity for researchers working on the various facets of obesity to interact and initiate a dialogue in an effort to encourage increased interaction and collaboration from a more integrated perspective.