PLEIOTROPIC EFFECTS ON OBESITY AND LIPOPROTEINS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is Project 3 of Program Project "Diet and Genotype in Primate Atherosclerosis." The overarching objective of this project is to map, characterize and identify polymorphic genes that contribute to variation in susceptibility to obesity and their relationship to cardiovascular disease (CVD). Research in this project during the current and previous grant periods has led to the chromosomal localization of numerous quantitative trait loci (QTLs) contributing to the risk for obesity in baboons. The primary goal of the currently proposed work is the identification and characterization of specific gene(s) that underly QTLs previously identified, and that are associated with variation in obesity-related phenotypes reflecting adipose tissue accumulation or function. Secondly, we will examine the effects of chronic exposure to a high cholesterol high fat (HCHF) diet on the expression levels of important obesity-related proteins that are thought to play a role in mediating insulin resistance, and ultimately to increased risk for the development of atherosclerosis. Finally, we will attempt to strengthen previously detected obesity-related QTLs and to discover new QTLs by including additional covariates and by investigating a variety of interaction models.