GASTROINTESTINAL PEPTIDES IN GLUCOSE REGULATION
胃肠肽在血糖调节中的作用
基本信息
- 批准号:7716149
- 负责人:
- 金额:$ 0.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-05-01 至 2009-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAnimal ModelBlood VolumeComputer Retrieval of Information on Scientific Projects DatabaseDataDevelopmentDiabetes MellitusDiseaseEmployee StrikesFundingFutureGlucoseGlucose IntoleranceGrantHumanInfusion proceduresInstitutionIntestinesModalityModelingNon-Insulin-Dependent Diabetes MellitusPapioPeptide YYPeptidesPhysiologyPilot ProjectsPrimatesProtocols documentationResearchResearch PersonnelResolutionResourcesRodent ModelSourceStudy modelsUnited States National Institutes of Healthbariatric surgeryblood glucose regulationdesigngastric inhibitory polypeptide receptorgastrointestinalghrelinglucagon-like peptide 1glucose metabolismmalepreventresponse
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Recent research findings have implicated several gastrointestinal (GI) peptides in the development of type 2 diabetes. In addition, manipulation of GI peptides may prove to be an effective means of treating and preventing the disorder. In particular, the modulation of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), peptide YY (PYY), and ghrelin concentrations have been shown to be effective in treating glucose intolerance or type 2 diabetes in rodent models. Moreover, the striking resolution of type 2 diabetes following roux-en Y gastric bypass surgery in humans has been attributed to the alterations in these peptides. Thus, these observations suggest that simultaneous manipulation of two or more of these GI peptides may provide new treatment modalities for type 2 diabetes. Hence, the development of animal models to study the effects of gastric bypass surgery and GI peptides on glucose metabolism is a high priority in diabetes research. Given, the large blood volumes that can be safely attained, the baboon represents a strong candidate for such a model. However, a clearer understanding of normal baboon GI peptide physiology will be an important initial step. The current Southwest National Primate Center pilot study will determine normal GLP-1, GIP, PYY, and ghrelin responses to an intestinal glucose challenge in ten adult male baboons. It is hypothesized that the responses observed in baboons will be similar to those of humans, i.e. increases in GLP-1, GIP, and PYY concentrations and a decrease in ghrelin concentrations. These data will be used in the design of future infusion protocols to assess the synergistic or antagonistic effects of these peptides on glucose metabolism. In addition, these data will help to determine the utility of the baboon as a model for studying the effects of GI peptide alteration resulting from gastric bypass surgery.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
最近的研究结果表明,几种胃肠道(GI)肽与2型糖尿病的发生有关。 此外,GI肽的操作可能被证明是治疗和预防该疾病的有效手段。 特别地,胰高血糖素样肽-I(GLP-1)、葡萄糖依赖性促胰岛素多肽(GIP)、肽YY(PYY)和生长素释放肽浓度的调节已显示在治疗啮齿动物模型中的葡萄糖耐受不良或2型糖尿病中有效。 此外,人类Roux-en Y胃旁路手术后2型糖尿病的显著消退归因于这些肽的改变。 因此,这些观察结果表明,同时操作两种或更多种这些GI肽可以为2型糖尿病提供新的治疗方式。 因此,开发动物模型来研究胃旁路手术和GI肽对葡萄糖代谢的影响是糖尿病研究中的一个高度优先事项。 考虑到可以安全获得的大量血液,狒狒代表了这种模型的强有力的候选者。 然而,更清楚地了解正常狒狒胃肠道肽生理学将是重要的第一步。目前的西南国家灵长类动物中心试点研究将确定正常GLP-1,GIP,PYY,和胃饥饿素的反应,肠道葡萄糖的挑战,在10个成年雄性狒狒。 假设在狒狒中观察到的反应与人类相似,即GLP-1、GIP和PYY浓度升高,胃饥饿素浓度降低。 这些数据将用于设计未来的输注方案,以评估这些肽对葡萄糖代谢的协同或拮抗作用。 此外,这些数据将有助于确定狒狒作为研究胃旁路手术引起的GI肽改变的影响的模型的实用性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anthony G. Comuzzie其他文献
ENTENDIENDO LAS CAUSAS DE LA OBESIDAD A TRAVÉS DE LA BIOLOGÍA CELULAR DEL ADIPOCITO. Revisión
ENTENDIENDO LAS CAUSAS DE LA OBESIDAD A TRAVÉS DE LA BIOLOGÍA CELULAR DEL ADIPOCITO。
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
Raul A. Bastarrachea;Ramón E. Fuenmayor;I. Brajkovich;Anthony G. Comuzzie - 通讯作者:
Anthony G. Comuzzie
Heritability of Ambulatory and Beat-to-Beat Office Blood Pressure in Large Multigenerational Arab Pedigrees: The ‘Oman Family Study’
大型多代阿拉伯谱系中动态血压和逐次搏动办公室血压的遗传性:“阿曼家庭研究”
- DOI:
10.1017/thg.2012.59 - 发表时间:
2012 - 期刊:
- 影响因子:0.9
- 作者:
S. Albarwani;M. Munoz;V. S. Voruganti;D. Jaju;V. Saeed Al;S. Rizvi;J. López;Zahir M Al;R. Bayoumi;Anthony G. Comuzzie;H. Snieder;M. Hassan - 通讯作者:
M. Hassan
Genómica de la regulación del peso corporal: mecanismos moleculares que predisponen a la obesidad
Genómica de la regulación del peso corporal: mecanismos moleculares que predisponen a la obesidad
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
Raul A. Bastarrachea;Shelley A. Cole;Anthony G. Comuzzie - 通讯作者:
Anthony G. Comuzzie
A Family Study in Oman: Large, Consanguineous, Polygamous Omani Arab Pedigrees
阿曼的家庭研究:庞大、近亲、一夫多妻制的阿曼阿拉伯血统
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:1.7
- 作者:
M. Hassan;S. Albarwani;S. A. Yahyaee;S. A. Haddabi;S. Rizwi;A. Jaffer;J. Al;G. Cai;Anthony G. Comuzzie;R. Bayoumi - 通讯作者:
R. Bayoumi
Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects
瘦、超重和肥胖受试者对精神和身体压力的血流动力学和自主反应
- DOI:
10.15744/2455-7633.2.105 - 发表时间:
2016 - 期刊:
- 影响因子:2.7
- 作者:
D. Jaju;M. Alabri;Hassan Mo;Alvarenga Jl;Anthony G. Comuzzie;S. Albarwani;S. AlYahyee;R. Bayoumi;K. Alhashmi - 通讯作者:
K. Alhashmi
Anthony G. Comuzzie的其他文献
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{{ truncateString('Anthony G. Comuzzie', 18)}}的其他基金
FASEB SRC on From Causes to Consequences, to Treatment: Obesity in Perspective
FASEB SRC 探讨从原因到后果,再到治疗:肥胖的视角
- 批准号:
8400279 - 财政年份:2012
- 资助金额:
$ 0.25万 - 项目类别:
IDENTIFYING GENES FOR OBESITY QTLS RELATED TO CVD
识别与 CVD 相关的肥胖 QTLS 基因
- 批准号:
8357655 - 财政年份:2011
- 资助金额:
$ 0.25万 - 项目类别:
IDENTIFYING GENES FOR OBESITY QTLS RELATED TO CVD
识别与 CVD 相关的肥胖 QTLS 基因
- 批准号:
8172661 - 财政年份:2010
- 资助金额:
$ 0.25万 - 项目类别:
Identifying Genes for Obesity QTLs Related to CVD
识别与 CVD 相关的肥胖 QTL 基因
- 批准号:
8147442 - 财政年份:2010
- 资助金额:
$ 0.25万 - 项目类别:
CHARACTERIZATION OF NHPS DISPLAYING PHENOTYPES OF HUMAN DISEASES
显示人类疾病表型的 NHPS 特征
- 批准号:
7957962 - 财政年份:2009
- 资助金额:
$ 0.25万 - 项目类别:
BASAL HEPATIC GLUCOSE AND INSULIN SENSITIVITY IN BABOONS
狒狒的基础肝葡萄糖和胰岛素敏感性
- 批准号:
7562448 - 财政年份:2007
- 资助金额:
$ 0.25万 - 项目类别:
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