CLINICAL CORE

梅奥阿尔茨海默病研究中心临床核心的总体目标是通过 招募和仔细诊断患者和对照，关于临床痴呆的各种项目是 在罗切斯特和杰克逊维尔的梅奥诊所进行。临床核心的具体目标是： 1.招募和跟踪AD退化谱上的受试者，特别关注早期疾病 (MCI)； 2.招募AD退化谱上的非裔美国人受试者，特别关注早期 疾病(MCI)； 3.招募和跟踪患有非阿尔茨海默病的受试者，例如额颞叶痴呆症、 路易小体，皮质基底部变性； 4.获得正常受试者、MCI和痴呆症患者(AD、额颞痴呆和路易)的DMA 身体痴呆症)，以支持与康复和康复中心有关的遗传项目，包括项目2和3；以及 5.为神经病理学核心和ADRC相关项目提供需要临床- 病理相关性。 在过去的拨款周期中，临床核心在招募和保留受试者方面非常成功。这个 CORE在几个领域也非常有成效，包括在轻度认知障碍的成像方面， 阿尔茨海默病和非阿尔茨海默病。核心也在很大程度上参与了 额颞叶变性的研究进展--作为PGRN基因突变的一些关键家族 基因最初被招募并在临床核心中进行评估。 对于目前的提议，我们打算继续招募包括白人和非洲人在内的正常志愿者。 美国人。我们还将招募有轻度认知障碍、阿尔茨海默病、路易体的患者 痴呆症、额颞叶变性和皮质基底膜变性。我们所有的研究对象都会 根据国家反腐败委员会规定的统一数据集的标准进行表征。 相关性(请参阅说明)： 临床核心是梅奥ADRC的核心。核心招聘，特点和遵循一个大型 正常对照组以及轻度认知障碍和各种痴呆患者的数量， 那么，谁是亚洲发展研究中心支持的各种研究项目的参与者。

The overall goal of the Mayo Alzheimer Disease Research Center Clinical Core is to support, through the recruitment and careful diagnosis of patients and controls, the various projects on clinical dementia that are ongoing at the Mayo Clinic Rochester and Jacksonville. The specific aims of the Clinical Core are to: 1. Recruit and follow subjects on the AD degenerative spectrum with a particular focus on early disease (MCI); 2. Recruit African-Americansubjects on the AD degenerative spectrum with special focus on early disease (MCI); 3. Recruit and follow subjects with non-AD dementia, e.g., frontotemporal dementia, dementia with Lewy bodies, corticobasal degeneration; 4. Obtain DMA on control subjects, MCI and dementia patients (AD, frontotemporal dementia and Lewy Body Dementia) in order to support ADRC related genetic projects including Projects 2 and 3; and 5. Supply subjects for the Neuropathology Core and ADRC related projects that require clinical- pathological correlation. In the past grant cycle, the Clinical Core has been very successful in recruiting and retaining subjects. The Core has also been very productive in several areas including in imaging in mild cognitive impairment, Alzheimer disease and the non-Alzheimer Dementias. The Core was also heavily involved in the genetic advances in frontotemporal lobar degeneration, as some of the pivotal families the mutations in the PGRN gene were initially recruited and evaluated in the Clinical Core. For the current proposal, we intend to continue to recruit normal volunteers including both whites and African Americans. We will also recruit patients with mild cognitive impairment, Alzheimer disease, Lewy body dementia, frontotemporal lobar degeneration and corticobasal degeneration. All of our subjects will be characterized according to the criteria of the Uniform Data Set specified by the NACC. RELEVANCE (Seeinstructions): The Clinical Core is the centerpiece of the Mayo ADRC. The Core recruits, characterizes and follows a large number of normal control subjects as well as patients with mild cognitive impairment and various dementias, who then are the participants in the various research projects supported by the ADRC.