CLINICAL CORE
CLINICAL CORE
批准号:
7624820
负责人:
RONALD C PETERSEN
金额:
$65.83万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-05-01 至 2014-04-30
关键词:
AfricanAfrican AmericanAlzheimer&aposs DiseaseAreaClinicClinicalData SetDementiaDiagnosisDiseaseFamilyFrontotemporal DementiaFrontotemporal Lobar DegenerationsGeneticGoalsGrantImageLewy BodiesLewy Body DiseaseMutationPGRN geneParticipantPatientsRecruitment ActivityResearchResearch Project GrantsSpecific qualifier valueSyndromecorticobasal degenerationmild neurocognitive impairmentneuropathologynon-alzheimer dementiavolunteer
中文摘要
梅奥阿尔茨海默病研究中心临床核心的总体目标是通过
招募和仔细诊断患者和对照,关于临床痴呆的各种项目是
在罗切斯特和杰克逊维尔的梅奥诊所进行。临床核心的具体目标是:
1.招募和跟踪AD退化谱上的受试者,特别关注早期疾病
(MCI);
2.招募AD退化谱上的非裔美国人受试者,特别关注早期
疾病(MCI);
3.招募和跟踪患有非阿尔茨海默病的受试者,例如额颞叶痴呆症、
路易小体,皮质基底部变性;
4.获得正常受试者、MCI和痴呆症患者(AD、额颞痴呆和路易)的DMA
身体痴呆症),以支持与康复和康复中心有关的遗传项目,包括项目2和3;以及
5.为神经病理学核心和ADRC相关项目提供需要临床-
病理相关性。
在过去的拨款周期中,临床核心在招募和保留受试者方面非常成功。这个
CORE在几个领域也非常有成效,包括在轻度认知障碍的成像方面,
阿尔茨海默病和非阿尔茨海默病。核心也在很大程度上参与了
额颞叶变性的研究进展--作为PGRN基因突变的一些关键家族
基因最初被招募并在临床核心中进行评估。
对于目前的提议,我们打算继续招募包括白人和非洲人在内的正常志愿者。
美国人。我们还将招募有轻度认知障碍、阿尔茨海默病、路易体的患者
痴呆症、额颞叶变性和皮质基底膜变性。我们所有的研究对象都会
根据国家反腐败委员会规定的统一数据集的标准进行表征。
相关性(请参阅说明):
临床核心是梅奥ADRC的核心。核心招聘,特点和遵循一个大型
正常对照组以及轻度认知障碍和各种痴呆患者的数量,
那么,谁是亚洲发展研究中心支持的各种研究项目的参与者。
英文摘要
The overall goal of the Mayo Alzheimer Disease Research Center Clinical Core is to support, through the
recruitment and careful diagnosis of patients and controls, the various projects on clinical dementia that are
ongoing at the Mayo Clinic Rochester and Jacksonville. The specific aims of the Clinical Core are to:
1. Recruit and follow subjects on the AD degenerative spectrum with a particular focus on early disease
(MCI);
2. Recruit African-Americansubjects on the AD degenerative spectrum with special focus on early
disease (MCI);
3. Recruit and follow subjects with non-AD dementia, e.g., frontotemporal dementia, dementia with
Lewy bodies, corticobasal degeneration;
4. Obtain DMA on control subjects, MCI and dementia patients (AD, frontotemporal dementia and Lewy
Body Dementia) in order to support ADRC related genetic projects including Projects 2 and 3; and
5. Supply subjects for the Neuropathology Core and ADRC related projects that require clinical-
pathological correlation.
In the past grant cycle, the Clinical Core has been very successful in recruiting and retaining subjects. The
Core has also been very productive in several areas including in imaging in mild cognitive impairment,
Alzheimer disease and the non-Alzheimer Dementias. The Core was also heavily involved in the genetic
advances in frontotemporal lobar degeneration, as some of the pivotal families the mutations in the PGRN
gene were initially recruited and evaluated in the Clinical Core.
For the current proposal, we intend to continue to recruit normal volunteers including both whites and African
Americans. We will also recruit patients with mild cognitive impairment, Alzheimer disease, Lewy body
dementia, frontotemporal lobar degeneration and corticobasal degeneration. All of our subjects will be
characterized according to the criteria of the Uniform Data Set specified by the NACC.
RELEVANCE (Seeinstructions):
The Clinical Core is the centerpiece of the Mayo ADRC. The Core recruits, characterizes and follows a large
number of normal control subjects as well as patients with mild cognitive impairment and various dementias,
who then are the participants in the various research projects supported by the ADRC.
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会议论文
MarkVCID Validation in the General Community
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批准号:10364014
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项目类别:
-
资助金额:$245.42万
-
财政年份:2021
-
负责人:RONALD C PETERSEN
-
依托单位:
MarkVCID Validation in the General Community
-
批准号:10619433
-
项目类别:
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资助金额:$364.68万
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财政年份:2021
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负责人:RONALD C PETERSEN
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依托单位:
Administrative Core
-
批准号:10413830
-
项目类别:
-
资助金额:$57.77万
-
财政年份:2019
-
负责人:RONALD C PETERSEN
-
依托单位:
Administrative Core
-
批准号:10657550
-
项目类别:
-
资助金额:$61.06万
-
财政年份:2019
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:10413829
-
项目类别:
-
资助金额:$300.45万
-
财政年份:2019
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:10657549
-
项目类别:
-
资助金额:$321.81万
-
财政年份:2019
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center Supplement (Identification and measurement of influences on brain donation decision making in African Americans)
-
批准号:10602684
-
项目类别:
-
资助金额:$24.04万
-
财政年份:2019
-
负责人:RONALD C PETERSEN
-
依托单位:
ADMINISTRATIVE CORE
-
批准号:7624819
-
项目类别:
-
资助金额:$14.45万
-
财政年份:2009
-
负责人:RONALD C PETERSEN
-
依托单位:
ADMINISTRATIVE CORE
-
批准号:6798065
-
项目类别:
-
资助金额:$9.4万
-
财政年份:2004
-
负责人:RONALD C PETERSEN
-
依托单位:
MAYO ALZHEIMERS DISEASE RESEARCH CENTER
-
批准号:6788404
-
项目类别:
-
资助金额:$7.16万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
MAYO ALZHEIMERS DISEASE RESEARCH CENTER
-
批准号:6631492
-
项目类别:
-
资助金额:$173.41万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
MAYO ALZHEIMERS DISEASE RESEARCH CENTER
-
批准号:6509781
-
项目类别:
-
资助金额:$182.4万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:7283853
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:7065699
-
项目类别:
-
资助金额:$185.61万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:8676245
-
项目类别:
-
资助金额:$195.71万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:8065956
-
项目类别:
-
资助金额:$191.84万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:6901821
-
项目类别:
-
资助金额:$181.93万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:7104568
-
项目类别:
-
资助金额:$6.64万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
Mayo Alzheimer's Disease Research Center
-
批准号:6952569
-
项目类别:
-
资助金额:$0.2万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
MAYO ALZHEIMER'S DISEASE RESEARCH CENTER-SUPPLEMENT
-
批准号:6230382
-
项目类别:
-
资助金额:$26.95万
-
财政年份:1999
-
负责人:RONALD C PETERSEN
-
依托单位:
海外基金