Mayo Alzheimer's Disease Research Center Supplement (Identification and measurement of influences on brain donation decision making in African Americans)

梅奥阿尔茨海默病研究中心增刊（识别和测量对非裔美国人大脑捐赠决策的影响）

• 批准号: 10602684
• 负责人: RONALD C PETERSEN
• 金额: $ 24.04万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10602684
• 关键词: Address; African American population; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Area; Basic Science; Biological; Biological Markers; Biological Models; Brain; Cells; Clinic; Clinical; Decision Making; Dementia; Development; Diagnosis; Disease; Environment; Evolution; Florida; Frontotemporal Lobar Degenerations; Functional disorder; General Population; Genes; Geographic Locations; Goals; Grant; Industrialization; Investigation; Lewy Body Dementia; Lewy Body Disease; Link; Liquid substance; Measurement; Minnesota; National Institute on Aging; Neurodegenerative Disorders; Participant; Pathologic; Patient Recruitments; Process; Randomized Controlled Trials; Research; Research Personnel; Resources; Site; Stem Cell Research; Structure; Theoretical model; Training; Translations; clinical biomarkers; cohort; data management; education research; education resources; effective therapy; frontotemporal degeneration; heuristics; imaging genetics; induced pluripotent stem cell; innovation; monocyte; neuroimaging; neuropathology; operation; outreach; peripheral blood; ranpirnase; recruit; research and development

PROJECT SUMMARY/ABSTRACT - OVERALL The overall goal of Mayo Clinic Alzheimer's Disease Research Center (ADRC) is to provide a structured environment that supports innovative research and enables translation aimed at accelerating the development of effective treatment and prevention for AD patients at all stages of the disease. Our comprehensive ADRC is located in Rochester, Minnesota (MCR), and Jacksonville, Florida (MCF), and shares its operations in all of the Cores between the two geographic sites. The sites are linked electronically yielding a seamless operation. The ADRC will be comprised of seven cores: Administrative Core, Clinical Core, Neuropathology Core, Data Management and Statistical Core, Outreach, Recruitment and Engagement Core, Neuroimaging Core and a new Biomarker Core. In addition, the Center will have a Research Education Component. The Mayo ADRC focuses on both Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) such as frontotemporal lobar degeneration and Lewy body disorders. As such, the theme of the ADRC is Similarities and Differences among Neurodegenerative Diseases. This focus will expand on previous accomplishments of the ADRC across the neurodegenerative disease spectra. The acquisition and development of new biomarkers for the neurodegenerative diseases will be a major focus of the Center, and the recruitment of research participants in all three disorders will enhance randomized controlled trial studies. A major emphasis of the new grant period will be the development of the Research Education Component with activities for trainees at all levels. Mayo Clinic has extensive educational resources for both local and national impact and these resources will be leveraged to attract and retain early stage investigators and those who are new to dementia research with an emphasis on diversity. The Mayo ADRC will interact with other ADRCs on various collaborative efforts and will continue to be a major contributor to the field.

项目概要/摘要 - 总体 梅奥诊所阿尔茨海默病研究中心 (ADRC) 的总体目标是提供 支持创新研究并实现旨在加速翻译的结构化环境 为 AD 患者在疾病的各个阶段开发有效的治疗和预防方法。我们的 综合 ADRC 位于明尼苏达州罗彻斯特 (MCR) 和佛罗里达州杰克逊维尔 (MCF)，并且 在两个地理位置之间的所有核心中共享其运营。这些网站已链接 以电子方式实现无缝操作。 ADRC 将由七个核心组成： 行政核心、临床核心、神经病理学核心、数据管理和统计核心、 外展、招聘和参与核心、神经影像核心和新的生物标记核心。在 此外，该中心还将设有研究教育部分。梅奥 ADRC 重点关注这两方面 阿尔茨海默病 (AD) 和阿尔茨海默病相关痴呆 (ADRD)，例如额颞叶痴呆 脑叶变性和路易体疾病。因此，ADRC 的主题是相似性和 神经退行性疾病之间的差异。这一重点将扩大以前的成就 ADRC 涵盖神经退行性疾病谱系。新产品的收购和开发 神经退行性疾病的生物标志物将成为该中心的主要关注点，并且招募 所有三种疾病的研究参与者将加强随机对照试验研究。一个专业 新资助期的重点将是研究教育部分的发展 为各级学员开展的活动。梅奥诊所拥有广泛的教育资源，适用于当地和 国家影响力和这些资源将被用来吸引和留住早期研究人员 那些刚接触痴呆症研究并强调多样性的人。梅奥 ADRC 将互动 与其他 ADRC 进行各种合作，并将继续成为该领域的主要贡献者。