Mayo Alzheimer's Disease Research Center

项目摘要/摘要--总体 梅奥诊所阿尔茨海默病研究中心(ADRC)的总体目标是提供 支持创新研究并支持旨在加速翻译的结构化环境 制定有效治疗和预防阿尔茨海默病患者疾病各个阶段的方法。我们的 综合ADRC位于明尼苏达州罗切斯特(MCR)和佛罗里达州杰克逊维尔(MCF)，以及 在两个地理位置之间的所有核心共享其运营。这些站点是链接的 以电子方式实现无缝操作。ADRC将由七个核心组成： 行政核心，临床核心，神经病理学核心，数据管理和统计核心， 外展、招聘和参与核心、神经成像核心和新的生物标记核心。在……里面 此外，该中心还将有一个研究教育部分。梅奥ADRC专注于这两个方面 阿尔茨海默病(AD)和阿尔茨海默病相关痴呆(ADRD)，如额颞部 脑叶变性和路易体疾病。因此，ADRC的主题是相似性和 神经退行性疾病之间的区别。这一重点将在以往成就的基础上扩展 神经退行性疾病谱系中的ADRC。新技术的获取和发展 神经退行性疾病的生物标记物将是该中心的主要重点，招募 所有三种疾病的研究参与者将加强随机对照试验研究。一位少校 新的赠款期间的重点将是研究教育部分的发展， 为各级学员举办活动。梅奥诊所拥有丰富的教育资源，适合当地和 国家影响力和这些资源将被用来吸引和留住早期调查人员和 那些对痴呆症研究不熟悉的人，强调多样性。梅奥ADRC将与 与其他区域发展研究中心开展各种协作努力，并将继续成为该领域的主要贡献者。

PROJECT SUMMARY/ABSTRACT - OVERALL The overall goal of Mayo Clinic Alzheimer's Disease Research Center (ADRC) is to provide a structured environment that supports innovative research and enables translation aimed at accelerating the development of effective treatment and prevention for AD patients at all stages of the disease. Our comprehensive ADRC is located in Rochester, Minnesota (MCR), and Jacksonville, Florida (MCF), and shares its operations in all of the Cores between the two geographic sites. The sites are linked electronically yielding a seamless operation. The ADRC will be comprised of seven cores: Administrative Core, Clinical Core, Neuropathology Core, Data Management and Statistical Core, Outreach, Recruitment and Engagement Core, Neuroimaging Core and a new Biomarker Core. In addition, the Center will have a Research Education Component. The Mayo ADRC focuses on both Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) such as frontotemporal lobar degeneration and Lewy body disorders. As such, the theme of the ADRC is Similarities and Differences among Neurodegenerative Diseases. This focus will expand on previous accomplishments of the ADRC across the neurodegenerative disease spectra. The acquisition and development of new biomarkers for the neurodegenerative diseases will be a major focus of the Center, and the recruitment of research participants in all three disorders will enhance randomized controlled trial studies. A major emphasis of the new grant period will be the development of the Research Education Component with activities for trainees at all levels. Mayo Clinic has extensive educational resources for both local and national impact and these resources will be leveraged to attract and retain early stage investigators and those who are new to dementia research with an emphasis on diversity. The Mayo ADRC will interact with other ADRCs on various collaborative efforts and will continue to be a major contributor to the field.