Mayo Alzheimer's Disease Research Center

项目总结/摘要-总体 马约诊所阿尔茨海默病研究中心（ADRC）的总体目标是提供一个 结构化的环境，支持创新研究，并实现旨在加速 发展有效的治疗和预防AD患者在疾病的各个阶段。我们 综合ADRC位于明尼苏达州的罗切斯特（MCR）和佛罗里达的杰克逊维尔（MCF）， 在两个地理站点之间的所有核心中共享其操作。网站链接 电子地产生无缝操作。ADRC将由七个核心组成： 管理核心、临床核心、神经病理学核心、数据管理和统计核心， 外展，招募和参与核心，神经影像核心和一个新的生物标志物核心。在 此外，该中心将有一个研究教育部分。马约ADRC关注这两个方面 阿尔茨海默氏病（AD）和阿尔茨海默氏病相关痴呆（ADRD），例如额颞叶痴呆（frontotemporal dementias）。 脑叶变性和路易体疾病。因此，ADRC的主题是相似性， 神经退行性疾病之间的差异这一重点将扩大以往的成就 ADRC在神经退行性疾病谱中的作用收购和开发新的 神经退行性疾病的生物标志物将是该中心的一个主要重点， 所有三种疾病的研究参与者将加强随机对照试验研究。一个主要 新补助金期间的重点将是研究教育部分的发展， 为各级学员举办的活动。马约诊所拥有广泛的教育资源， 这些资源将用于吸引和留住早期调查人员， 那些新的痴呆症研究，强调多样性。马约抗抑郁药中心将与 在各种合作努力中，发展筹资问题区域中心将与其他发展筹资问题区域中心合作，并将继续为实地工作作出主要贡献。

PROJECT SUMMARY/ABSTRACT - OVERALL The overall goal of Mayo Clinic Alzheimer's Disease Research Center (ADRC) is to provide a structured environment that supports innovative research and enables translation aimed at accelerating the development of effective treatment and prevention for AD patients at all stages of the disease. Our comprehensive ADRC is located in Rochester, Minnesota (MCR), and Jacksonville, Florida (MCF), and shares its operations in all of the Cores between the two geographic sites. The sites are linked electronically yielding a seamless operation. The ADRC will be comprised of seven cores: Administrative Core, Clinical Core, Neuropathology Core, Data Management and Statistical Core, Outreach, Recruitment and Engagement Core, Neuroimaging Core and a new Biomarker Core. In addition, the Center will have a Research Education Component. The Mayo ADRC focuses on both Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) such as frontotemporal lobar degeneration and Lewy body disorders. As such, the theme of the ADRC is Similarities and Differences among Neurodegenerative Diseases. This focus will expand on previous accomplishments of the ADRC across the neurodegenerative disease spectra. The acquisition and development of new biomarkers for the neurodegenerative diseases will be a major focus of the Center, and the recruitment of research participants in all three disorders will enhance randomized controlled trial studies. A major emphasis of the new grant period will be the development of the Research Education Component with activities for trainees at all levels. Mayo Clinic has extensive educational resources for both local and national impact and these resources will be leveraged to attract and retain early stage investigators and those who are new to dementia research with an emphasis on diversity. The Mayo ADRC will interact with other ADRCs on various collaborative efforts and will continue to be a major contributor to the field.