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Mayo Alzheimer's Disease Research Center

梅奥阿尔茨海默病研究中心

基本信息

批准号：
10657549
负责人：
RONALD C PETERSEN
金额：
$ 321.81万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10657549
关键词：
Acceleration Address Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Alzheimer’s disease biomarker Area Basic Science Biological Biological Markers Biological Models Cells Clinic Clinical Dementia Development Diagnosis Disease Environment Evolution Florida Frontotemporal Lobar Degenerations Functional disorder General Population Genes Genetic Geographic Locations Goals Grant Image Industrialization Institution Investigation Lewy Body Dementia Lewy Body Disease Link Liquid substance Minnesota National Institute on Aging Neurodegenerative Disorders Participant Pathologic Patient Recruitments Process Randomized, Controlled Trials Research Research Personnel Resources Site Stem Cell Research Structure Theoretical model Training Translations cohort data management education research education resources effective therapy frontotemporal degeneration heuristics induced pluripotent stem cell innovation monocyte neuroimaging neuropathology operation outreach peripheral blood recruit research and development

项目摘要

PROJECT SUMMARY/ABSTRACT - OVERALL The overall goal of Mayo Clinic Alzheimer's Disease Research Center (ADRC) is to provide a structured environment that supports innovative research and enables translation aimed at accelerating the development of effective treatment and prevention for AD patients at all stages of the disease. Our comprehensive ADRC is located in Rochester, Minnesota (MCR), and Jacksonville, Florida (MCF), and shares its operations in all of the Cores between the two geographic sites. The sites are linked electronically yielding a seamless operation. The ADRC will be comprised of seven cores: Administrative Core, Clinical Core, Neuropathology Core, Data Management and Statistical Core, Outreach, Recruitment and Engagement Core, Neuroimaging Core and a new Biomarker Core. In addition, the Center will have a Research Education Component. The Mayo ADRC focuses on both Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) such as frontotemporal lobar degeneration and Lewy body disorders. As such, the theme of the ADRC is Similarities and Differences among Neurodegenerative Diseases. This focus will expand on previous accomplishments of the ADRC across the neurodegenerative disease spectra. The acquisition and development of new biomarkers for the neurodegenerative diseases will be a major focus of the Center, and the recruitment of research participants in all three disorders will enhance randomized controlled trial studies. A major emphasis of the new grant period will be the development of the Research Education Component with activities for trainees at all levels. Mayo Clinic has extensive educational resources for both local and national impact and these resources will be leveraged to attract and retain early stage investigators and those who are new to dementia research with an emphasis on diversity. The Mayo ADRC will interact with other ADRCs on various collaborative efforts and will continue to be a major contributor to the field.

项目摘要/摘要-总体

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Progressive supranuclear palsy can mimic idiopathic normal pressure hydrocephalus: A case series.

DOI：
10.1093/jnen/nlad090
发表时间：
2023-11-20
期刊：
Journal of neuropathology and experimental neurology
影响因子：
3.2
作者：
通讯作者：

Computerized Cognitive Training (CCT) versus Yoga Impact on 12 Month Post Intervention Cognitive Outcome in Individuals with Mild Cognitive Impairment.

计算机化认知训练（CCT）与瑜伽对患有轻度认知障碍患者的干预后认知结果的影响对瑜伽的影响。

DOI：
10.3390/brainsci11080988
发表时间：
2021-07-27
期刊：
Brain sciences
影响因子：
3.3
作者：
Phatak VS;Smith GE;Locke D;Shandera-Ochsner A;Dean PM;Ball C;Gutierrez G;Chandler MJ
通讯作者：
Chandler MJ

Charting the meningeal lymphatic network.

绘制脑膜淋巴网络。