DATA MANAGEMENT AND STATISTICAL CORE

UCSF ADRC将整合基础科学和临床资源，研究临床，成像， 早期阿尔茨海默病（AD）、非AD痴呆、轻度的分子和神经病理学特征 认知障碍（MCI）和健康老龄化。数据管理和统计（DMS）核心将支持 这一使命与研究设计，生物统计学，和数据管理基础设施，确保1） 行为、认知、神经、成像和遗传信息的测量得到以下方面的支持： 科学和临床上合理的技术，导致信息的一致分类（即，表示“间” 2）观察到的现象被准确记录; 3）记录的 测量结果准确地反映在数据库中; 4）数据库是安全的， 未经授权的更改; 5）研究者可以访问分析数据集;以及6）有意义的 使用适当的研究设计和生物统计方法确定数据中的模式。 我们的具体目标是：1）为ADRC提供高质量的研究设计和生物统计咨询- 相关的核心，项目和试点，并促进利用ADRC数据的合作研究项目， 2）开发和维护集中的、集成的数据管理系统， 确保行政、临床和研究信息的准确性、可用性和保密性的程序 来自ADRC核心、项目和试点的数据; 3）开发和维护适当的数据管理， 质量保证流程，以确保及时准确地收集、验证和提交所有 数据库到NACC。 相关性（参见说明）： UCSF ADRC对阿尔茨海默病、非典型痴呆、轻度认知障碍和正常人的研究 衰老依赖于全面和可用的数据库，这些数据库可以准确地捕捉诊断、自然 病史，基因型和表型之间的相互作用，临床病理关系，相互作用 脑结构和功能变化与神经行为障碍以及其他临床 特色

The UCSF ADRC will integrate basic science and clinical resources to investigate the clinical, imaging, molecular, and neuropathological features of early Alzheimer's disease (AD), non-AD dementias, mild cognitive impairment (MCI) and healthy aging. The Data Management and Statistics (DMS) core will support this mission with a research design, biostatistics, and data management infrastructure that ensures 1) the measurement of behavioral, cognitive, neurological, imaging and genetic information is supported by scientifically and clinically sound techniques that result in a consistent classification of information (i.e., inter- rater reliability); 2) that the observed phenomena are accurately recorded; 3) that the recorded measurements are accurately reflected in the database; 4) that the database is secure, preventing unauthorized changes; 5) that analytical data sets are accessible to investigators; and 6) that meaningful patterns in the data are identified using appropriate research design and biostatistical methods. Our specific aims are 1) Provide high-quality research design and biostatistical consultation for ADRC- related cores, projects, and pilots and promote collaborative research projects utilizing ADRC data, specimens, and subjects; 2) Develop and maintain centralized, integrated, data management systems and procedures to ensure the accuracy, availability, and confidentiality of administrative, clinical and research data from ADRC cores, projects, and pilots; 3) Develop and maintain appropriate data management and quality assurance processes to ensure the timely and accurate collection, verification, and submission of all datasets to the NACC. RELEVANCE (See instructions): The UCSF ADRC studies of Alzheimer's disease, atypical dementias, mild cognitive impairment, and normal aging depend upon comprehensive and available databases that accurately capture diagnosis, natural history, interactions between genotype and phenotype, clinico-pathological relationships, interactions between structural and functional brain changes and neurobehavioral disturbance, and other clinical characteristics.