Predictors of cognitive aging across the lifecourse

描述（由申请人提供）：该提案要求继续NIA资助Kristine Yaffe博士的以患者为导向的研究（K24）中期职业研究者奖。K24更新申请的总体目标有三个方面：1）在一个新的方向上进行严格的以患者为基础的研究，旨在确定认知老化和结构性大脑完整性的预测因素，这些预测因素贯穿了birthday成年人的整个生命过程，2）将申请人的研究作为认知老化流行病学中以患者为导向的研究人员的指导平台，以及3）使申请人能够追求新的研究方向，并继续支持她作为国际公认的导师，为来自对认知老化感兴趣的广泛学科的学员提供发展。在K24奖提供的前5年支持期间，Yaffe博士既是一位非常富有成效的导师，也是一位独立资助的研究者。在此期间，她获得了八项以患者为导向的研究赠款（3个R01，2个NIH项目核心，阿尔茨海默氏症协会的研究者发起的研究资助，国防部资助和美国健康基金会资助）。在2007年至2012年的K24项目初期，Yaffe博士曾担任19名学员的初级或中级导师，涉及广泛的学科和不同级别的培训。Yaffe博士的长期目标是成为老龄化研究的国际领导者，为我们对认知障碍的治疗和预防的理解和方法做出实质性贡献，并指导对认知老化流行病学感兴趣的“下一代”研究人员。职业中期发展奖的一次性续期将帮助她实现这些目标。

DESCRIPTION (provided by applicant): This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient- Oriented Research (K24) to Dr. Kristine Yaffe. The overarching aims of this K24 renewal application are three-fold: 1) To perform rigorous patient-based research studies in a new direction aimed at the identification of the predictors of cognitive aging and structural brain integrity across the lifecourse among biracial adults, 2) To use the applicant's research as a platform for the mentorship of patient-oriented researchers in the epidemiology of cognitive aging and 3) To enable the applicant to pursue new research directions and to continue to support her development as an internationally recognized mentor for trainees from a wide range of disciplines interested in cognitive aging. During the first 5 years of support provided by the K24 award, Dr. Yaffe has been both a very productive mentor and independently funded investigator. During this period, she has obtained eight patient-oriented research grants (3 R01s, 2 Project Cores on Program Projects from NIH, an Investigator-Initiated Research Grant from the Alzheimer's Association, a Department of Defense grant and an American Health Foundation grant). Over the initial K24 project period from 2007 to 2012, Dr. Yaffe has served as primary or secondary mentor to 19 trainees in a wide range of disciplines and at various levels of training. Dr. Yaffe's long-term goals are to become an international leader in aging research, to contribute substantially to our understanding and approaches to the treatment and prevention of cognitive impairment and to mentor the "next generation" of investigators interested in the epidemiology of cognitive aging. This one-time renewal of a mid-career development award will help her to reach these goals.