Predictors & Outcomes of Cognitive Trajectories in the Oldest Old

描述（由申请人提供）：这是一份申请K24中年职业研究者奖在与衰老相关的面向患者的研究。该候选人是加州大学旧金山分校（UCSF）精神病学、神经病学和流行病学副教授，具有研究人员、临床医生和导师的良好记录。本提案的总体目标是确定老年人在9岁和10岁之间的认知轨迹，其预测因素和结果。我们建议从两项正在进行的nih资助的前瞻性研究中进行我们的目标，骨质疏松性骨折研究（SOF）和健康老龄化和身体成分研究（Health ABC）。我们将确定10至20年的认知功能纵向轨迹，生活在80和90岁的老年人，并确定预测，主要是新的生物标志物，这些认知轨迹。此外，我们将确定这些不同的轨迹如何影响重要的健康结果，如功能状态，死亡率和养老院安置。申请人将利用她的研究作为指导以患者为导向的研究人员的平台，并将促进认知衰老的多学科研究方法。受训者将参加研究研讨会、职业发展和拨款写作研讨会，以及正式的教学培训，包括K30临床研究课程和UCSF新资助的CTSA项目。候选人的优势包括她在研究方法方面的正式培训，她的研究生产力和NIH资助的历史，包括几个活跃的r01，以及她早期指导初级学员的记录。该所的优势包括拥有K30和CTSA的资源、若干T32和K12培训补助金，以获得潜在的学员，以及提供资源以促进初级研究人员的研究。该奖项将有助于推进申请人在认知衰老流行病学方面的研究，并指导“下一代”致力于认知衰老患者导向研究的研究人员。

DESCRIPTION (provided by applicant): This is an application for a K24 Midcareer Investigator Award in aging-related patient-oriented research. The candidate is an associate professor of psychiatry, neurology and epidemiology at the University of California, San Francisco (UCSF) with an established record as a researcher, clinician, and mentor. The overarching aims of this proposal are to identify cognitive trajectories, their predictors and outcomes among elders in their 9th and 10 decade of life. We propose to conduct our aims from two ongoing NIH-funded prospective studies, the Study of Osteoporotic Fractures (SOF) and the Health Aging and Body Composition Study (Health ABC). We will determine the 10- to 20-year longitudinal trajectories of cognitive function of elders living into their 80's and 90's and to identify the predictors, primarily novel biomarkers, of these cognitive trajectories. In addition, we will determine how these different trajectories influence important health outcomes such as functional status, mortality and nursing home placement. The applicant will use her research as a platform for the mentorship of patient-oriented researchers and will promote a multidisciplinary research approach to cognitive aging. Trainees will participate in research seminars, career development and grant-writing workshops, and in formal didactic training including the K30 Clinical Research Curriculum and the newly funded CTSA program at UCSF. Strengths of the candidate include her formal training in research methods, her history of research productivity and NIH funding including several active R01s, and her early track record of mentoring junior trainees. Strengths of the institution include the resources of the K30 and CTSA, several T32 and K12 training grants from which to garner potential mentees, and the availability of resources to foster research of junior investigators. This award will be instrumental in advancing the applicant's research in the epidemiology of cognitive aging and in mentoring the "next generation" of investigators committed to cognitive aging patient-oriented research.