Population Based Research for Alzheimer's Innovation (POP BRAIN)

摘要 博士Yaffe的背景和成就使她成为R35领导层的理想人选 ADRD奖，重点是人口研究的AD/ADRD研究实施里程碑， 精准医疗和健康差距。在过去的20年里，PI和她的团队领导了一项研究， ADRD的流行病学项目。在这一广泛的主题下，Yaffe博士专注于旨在 确定风险因素，特别是那些可以改变的风险因素（问题的关键组成部分）， 临床认知能力下降和ADRD。她的团队领导了对身体活动、睡眠质量、 心血管风险因素、创伤性脑损伤和其他关键风险因素。为了实现下一个 研究和培训平台符合人口研究里程碑，该团队将创造一个令人兴奋的 多学科计划题为，UCSF人口为基础的研究阿尔茨海默氏症的创新或流行， 个脑袋Yaffe博士组建了一个杰出的多学科领导小组，以推进ADRD 人口健康沿着一个高度创新和有影响力的路线图， 研究人员的发展。R35机制是一个理想的平台，以提高博士Yaffe的以前的线， 调查人口健康，但也转向更加重视三个主题， 里程碑1.B：1）风险因素的生命过程方法和研究生命的新分析方法- 2）强调不同的人群，以及如何麻烦和生命过程中的暴露可能 不同的群体（按种族/民族和性别），并提供深入了解风险机制和3）和 健康和生物途径的麻烦、社会决定因素之间相对未探索的相互关系 的ADRD。我们将使用现有的和新的分析方法进行这些研究， 研究者领导或具有丰富经验的几个队列。实施这一创新 调查路线将突出新的预防战略，强调健康的基础， ADRD风险的差异，并为ADRD的生命过程病因学提供新的见解。在一个同样重要的 作为一项使命，Pop-Brain计划将培养来自不同学科的初级调查员的职业生涯 关注ADRD的人群健康。这将涉及新的资源以及利用和协调 加州大学旧金山分校现有但不同的项目。该计划将提供指导，教学，研究设计和 生物统计指导，试点资金和职业发展活动，在统一的几个部门 致力于人口健康的中心。由于她的成就和对改善的深刻承诺， 通过严格的科学调查和培养下一代调查人员， 和她的Pop-Brain多学科专家团队处于理想的位置，可以获得领导奖 实现人口健康的里程碑。

ABSTRACT Dr. Yaffe's background and accomplishments make her ideally positioned for the proposed R35 Leadership Award in ADRD focusing on the AD/ADRD Research Implementation Milestones for population studies, precision medicine and health disparities. Over the past 20 years, the PI and her team have led a research program in the epidemiology of ADRD. Within this broad theme, Dr. Yaffe has focused on studies aimed at identifying risk factors, particularly those that are modifiable (a key component of the exposome), for pre- clinical cognitive decline and ADRD. Her team has led seminal investigations on physical activity, sleep quality, cardiovascular risk factors, traumatic brain injury and other key risk factors. In order to achieve the next platform of research and training in line with the Population Studies Milestone, the team will create an exciting multidisciplinary program entitled, the UCSF Population Based Research for Alzheimer's Innovation or Pop- BRAIN. Dr. Yaffe has assembled an outstanding multidisciplinary leadership group to advance ADRD population health along a highly innovative and impactful roadmap for discovery and next generation of researchers' development. The R35 mechanism is an ideal platform to enhance Dr. Yaffe's previous line of investigation in population health but also to pivot to greater emphasis on three themes that are nicely aligned with Milestone 1.B: 1) a life-course approach to risk factors and novel analytic approaches to studying the life- course exposome, 2) emphasis on diverse populations and how the exposome and life-course exposures may differ across groups (by race/ethnicity and sex) and provide insight into risk mechanisms and 3) and the relatively unexplored inter-relationship of the exposome, social determinants of health and biological pathways of ADRD. We will conduct these studies using established and novel analytic approaches for investigation in several cohorts that the investigators lead or have extensive experience with. Implementation of this innovative line of investigation will highlight new strategies for prevention, underscore the underpinnings for health disparities in risk of ADRD and offer new insights to the life-course etiology of ADRD. In an equally important mission, the Pop-BRAIN program will foster the careers of junior investigators from a variety of disciplines focused on population health for ADRD. This will involve new resources as well as leveraging and harmonizing existing but disparate programs at UCSF. The program will provide mentoring, didactics, research design and biostatistics guidance, pilot funding and career development activities across several departments in a unified hub dedicated to population health. Due to the caliber of her achievements and deep commitment to improving public health through rigorous scientific inquiry and developing the next generation of investigators, Dr. Yaffe and her Pop-BRAIN multidisciplinary team of experts are in an ideal position to embrace a Leadership Award and deliver on the Milestone in Population Health.