Population Based Research for Alzheimer's Innovation (POP BRAIN)

摘要 亚菲博士的背景和成就使她成为R35领导层的理想人选 ADRD奖，重点是AD/ADRD人口研究的实施里程碑， 精准医疗和健康差距。在过去的20年里，PI和她的团队领导了一项研究 ADRD流行病学研究项目。在这个广泛的主题中，亚菲博士专注于旨在 确定风险因素，特别是那些可修改的因素(曝光组的关键组成部分)，以预防 临床认知功能减退与ADRD她的团队领导了对体力活动、睡眠质量、 心血管危险因素、创伤性脑损伤等关键危险因素。为了实现下一步 研究和培训平台符合人口研究的里程碑，团队将创造一个令人兴奋的 名为加州大学旧金山分校基于人群的阿尔茨海默氏症创新研究或Pop- 大脑。亚菲博士组建了一个杰出的多学科领导小组，推动ADRD 人口健康，沿着高度创新和有影响力的路线图，发现和下一代 研究人员的发展。R35机制是一个理想的平台，可以增强雅菲博士之前的系列 调查人口健康，但也要更多地强调三个主题，这三个主题很好地结合在一起 里程碑1.B：1)风险因素的生命过程方法和研究生命的新分析方法- 课程暴露，2)强调不同的人群，以及暴露和生命过程暴露如何 不同群体之间的差异(按种族/民族和性别)，并提供对风险机制的洞察3)和 暴露组、健康的社会决定因素和生物途径之间相对未被探索的相互关系 是ADRD的。我们将使用现有的和新的分析方法进行这些研究，以便在#年进行调查 调查人员领导或有丰富经验的几个队列。实施这一创新 调查路线将突出新的预防战略，强调健康的基础 ADRD风险的差异，为ADRD的生命过程病因学提供了新的见解。在一个同样重要的领域 任务，流行大脑计划将促进来自不同学科的初级调查人员的职业生涯 ADRD的重点是人口健康。这将涉及新的资源以及杠杆和协调 加州大学旧金山分校现有但截然不同的项目。该计划将提供指导、教学、研究设计和 几个部门的生物统计指导、试点筹资和职业发展活动统一进行 致力于人口健康的中心。由于她取得的成就和对改进的坚定承诺 通过严格的科学研究和培养下一代研究人员，雅菲博士，公共卫生 她的Pop-Brain多学科专家团队处于获得领导力奖的理想位置 并实现人口健康的里程碑。

ABSTRACT Dr. Yaffe's background and accomplishments make her ideally positioned for the proposed R35 Leadership Award in ADRD focusing on the AD/ADRD Research Implementation Milestones for population studies, precision medicine and health disparities. Over the past 20 years, the PI and her team have led a research program in the epidemiology of ADRD. Within this broad theme, Dr. Yaffe has focused on studies aimed at identifying risk factors, particularly those that are modifiable (a key component of the exposome), for pre- clinical cognitive decline and ADRD. Her team has led seminal investigations on physical activity, sleep quality, cardiovascular risk factors, traumatic brain injury and other key risk factors. In order to achieve the next platform of research and training in line with the Population Studies Milestone, the team will create an exciting multidisciplinary program entitled, the UCSF Population Based Research for Alzheimer's Innovation or Pop- BRAIN. Dr. Yaffe has assembled an outstanding multidisciplinary leadership group to advance ADRD population health along a highly innovative and impactful roadmap for discovery and next generation of researchers' development. The R35 mechanism is an ideal platform to enhance Dr. Yaffe's previous line of investigation in population health but also to pivot to greater emphasis on three themes that are nicely aligned with Milestone 1.B: 1) a life-course approach to risk factors and novel analytic approaches to studying the life- course exposome, 2) emphasis on diverse populations and how the exposome and life-course exposures may differ across groups (by race/ethnicity and sex) and provide insight into risk mechanisms and 3) and the relatively unexplored inter-relationship of the exposome, social determinants of health and biological pathways of ADRD. We will conduct these studies using established and novel analytic approaches for investigation in several cohorts that the investigators lead or have extensive experience with. Implementation of this innovative line of investigation will highlight new strategies for prevention, underscore the underpinnings for health disparities in risk of ADRD and offer new insights to the life-course etiology of ADRD. In an equally important mission, the Pop-BRAIN program will foster the careers of junior investigators from a variety of disciplines focused on population health for ADRD. This will involve new resources as well as leveraging and harmonizing existing but disparate programs at UCSF. The program will provide mentoring, didactics, research design and biostatistics guidance, pilot funding and career development activities across several departments in a unified hub dedicated to population health. Due to the caliber of her achievements and deep commitment to improving public health through rigorous scientific inquiry and developing the next generation of investigators, Dr. Yaffe and her Pop-BRAIN multidisciplinary team of experts are in an ideal position to embrace a Leadership Award and deliver on the Milestone in Population Health.