Population Based Research for Alzheimer's Innovation (POP BRAIN)

基于人群的阿尔茨海默病创新研究 (POP BRAIN)

• 批准号: 10653866
• 负责人: Kristine Yaffe
• 金额: $ 94.53万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10653866
• 关键词: Achievement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Award; Biological; Biometry; Caliber; Dedications; Development; Discipline; Disparate; Epidemiology; Ethnic Origin; Etiology; Fostering; Funding; Impaired cognition; Investigation; Lead; Leadership; Life Cycle Stages; Mentors; Mission; Pathway interactions; Physical activity; Population Heterogeneity; Population Research; Population Study; Positioning Attribute; Precision Health; Prevention; Prevention strategy; Public Health; Race; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Scientific Inquiry; Seminal; Training; Traumatic Brain Injury; cardiovascular risk factor; career; career development; cohort; experience; health disparity; improved; innovation; insight; multidisciplinary; next generation; novel; population health; pre-clinical; precision medicine; programs; sex; sleep quality; social health determinants

ABSTRACT Dr. Yaffe's background and accomplishments make her ideally positioned for the proposed R35 Leadership Award in ADRD focusing on the AD/ADRD Research Implementation Milestones for population studies, precision medicine and health disparities. Over the past 20 years, the PI and her team have led a research program in the epidemiology of ADRD. Within this broad theme, Dr. Yaffe has focused on studies aimed at identifying risk factors, particularly those that are modifiable (a key component of the exposome), for pre- clinical cognitive decline and ADRD. Her team has led seminal investigations on physical activity, sleep quality, cardiovascular risk factors, traumatic brain injury and other key risk factors. In order to achieve the next platform of research and training in line with the Population Studies Milestone, the team will create an exciting multidisciplinary program entitled, the UCSF Population Based Research for Alzheimer's Innovation or Pop- BRAIN. Dr. Yaffe has assembled an outstanding multidisciplinary leadership group to advance ADRD population health along a highly innovative and impactful roadmap for discovery and next generation of researchers' development. The R35 mechanism is an ideal platform to enhance Dr. Yaffe's previous line of investigation in population health but also to pivot to greater emphasis on three themes that are nicely aligned with Milestone 1.B: 1) a life-course approach to risk factors and novel analytic approaches to studying the life- course exposome, 2) emphasis on diverse populations and how the exposome and life-course exposures may differ across groups (by race/ethnicity and sex) and provide insight into risk mechanisms and 3) and the relatively unexplored inter-relationship of the exposome, social determinants of health and biological pathways of ADRD. We will conduct these studies using established and novel analytic approaches for investigation in several cohorts that the investigators lead or have extensive experience with. Implementation of this innovative line of investigation will highlight new strategies for prevention, underscore the underpinnings for health disparities in risk of ADRD and offer new insights to the life-course etiology of ADRD. In an equally important mission, the Pop-BRAIN program will foster the careers of junior investigators from a variety of disciplines focused on population health for ADRD. This will involve new resources as well as leveraging and harmonizing existing but disparate programs at UCSF. The program will provide mentoring, didactics, research design and biostatistics guidance, pilot funding and career development activities across several departments in a unified hub dedicated to population health. Due to the caliber of her achievements and deep commitment to improving public health through rigorous scientific inquiry and developing the next generation of investigators, Dr. Yaffe and her Pop-BRAIN multidisciplinary team of experts are in an ideal position to embrace a Leadership Award and deliver on the Milestone in Population Health.

抽象的 Yaffe 博士的背景和成就使她成为拟议的 R35 领导层的理想人选 ADRD 奖项重点关注人口研究的 AD/ADRD 研究实施里程碑， 精准医疗和健康差异。在过去的 20 年里，PI 和她的团队领导了一项研究 ADRD 流行病学计划。在这个广泛的主题中，Yaffe 博士专注于旨在 识别风险因素，特别是那些可改变的因素（暴露组的关键组成部分），以便预防 临床认知能力下降和ADRD。她的团队领导了关于身体活动、睡眠质量、 心血管危险因素、创伤性脑损伤和其他关键危险因素。为了实现下一步 符合人口研究里程碑的研究和培训平台，该团队将创建一个令人兴奋的 题为“加州大学旧金山分校基于人口的阿尔茨海默病创新或流行研究”的多学科计划 脑。 Yaffe 博士组建了一支杰出的多学科领导小组来推进 ADRD 沿着高度创新和有影响力的路线图探索和下一代人口健康 研究人员的发展。 R35 机制是增强 Yaffe 博士之前系列产品的理想平台 人口健康调查，同时也更加重视三个紧密结合的主题 里程碑 1.B：1）针对风险因素的生命历程方法和研究生命的新颖分析方法 当然暴露组，2) 强调不同人群以及暴露组和生命历程暴露如何可能 不同群体之间存在差异（按种族/民族和性别），并提供对风险机制的深入了解，3) 和 暴露组、健康社会决定因素和生物途径之间相对尚未探索的相互关系 ADRD 的。我们将使用已建立的和新颖的分析方法进行这些研究，以进行调查 研究人员领导或拥有丰富经验的几个群体。这一创新的实施 调查路线将突出新的预防战略，强调健康的基础 ADRD 风险的差异，并为 ADRD 的生命过程病因学提供新的见解。在一个同样重要的 Pop-BRAIN 计划将促进各个学科的初级研究人员的职业生涯 ADRD 重点关注人口健康。这将涉及新资源以及利用和协调 加州大学旧金山分校现有但不同的项目。该计划将提供指导、教学、研究设计和 跨多个部门的生物统计指导、试点资助和职业发展活动统一进行 致力于人口健康的中心。由于她取得的成就和对提高的坚定承诺 亚菲博士通过严格的科学探究和培养下一代研究人员来促进公共卫生 和她的 Pop-BRAIN 多学科专家团队处于获得领导奖的理想位置 并实现人口健康的里程碑。

项目成果

Association of Adverse Childhood Experiences With Accelerated Epigenetic Aging in Midlife.

• DOI: 10.1001/jamanetworkopen.2023.17987
• 发表时间: 2023-06-01
• 期刊: JAMA network open
• 影响因子: 13.8

Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study.

• DOI: 10.1002/dad2.12263
• 发表时间: 2022
• 期刊: Alzheimer's & dementia (Amsterdam, Netherlands)
• 作者: King KS;Vintimilla RM;Braskie MN;Wei K;Hall JR;Borzage M;Johnson LA;Yaffe K;Toga AW;O'Bryant SE;HABLE Study Team
• 通讯作者: HABLE Study Team

The Metabolic Syndrome Is Associated With Lower Cognitive Performance and Reduced White Matter Integrity in Midlife: The CARDIA Study.

• DOI: 10.3389/fnins.2022.942743
• 发表时间: 2022
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Dintica, Christina S.;Hoang, Tina;Allen, Norrina;Sidney, Stephen;Yaffe, Kristine
• 通讯作者: Yaffe, Kristine

Long-term depressive symptoms and midlife brain age.

• DOI: 10.1016/j.jad.2022.09.164
• 发表时间: 2023-01-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Dintica, Christina S.;Habes, Mohamad;Erus, Guray;Simone, Tamar;Schreiner, Pamela;Yaffe, Kristine
• 通讯作者: Yaffe, Kristine

Constricting Life Space and Likelihood of Neurodegenerative Disease in Community-Dwelling Older Men.

• DOI: 10.1001/jamanetworkopen.2023.42670
• 发表时间: 2023-11-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Bock, Meredith A.;Hoang, Tina;Cawthon, Peggy;Mackey, Dawn C.;Patel, Sheena;Hillier, Teresa A.;Yaffe, Kristine
• 通讯作者: Yaffe, Kristine