VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Epidemiology Study
VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Epidemiology Study
批准号:
10595627
负责人:
Kristine Yaffe
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-10-01 至 2024-09-30
关键词:
AgeBrain InjuriesCaringCharacteristicsChronicClinicalCollaborationsComplexDataData PoolingData SetData SourcesDatabasesDementiaDiagnosisEthnic OriginEvolutionGenderGoalsHealthcare SystemsImageIndividualInterventionInvestigationLong-Term EffectsMedicalMedical centerMental HealthMilitary PersonnelModelingNerve DegenerationNervous System TraumaNeurodegenerative DisordersOutcomePatientsPharmaceutical PreparationsPhenotypePositioning AttributePost-Traumatic Stress DisordersPreventionPublic HealthRaceResearch PersonnelResourcesRiskRisk FactorsRisk ReductionSocioeconomic StatusSubgroupSubstance abuse problemTimeTranslatingTraumatic Brain InjuryUpdateVeteransWorkadverse outcomecare systemsclinical carecomorbiditycostdata repositorydementia riskearly onsetepidemiology studyfollow-uphealth care service utilizationimprovedlongitudinal coursemild traumatic brain injurymilitary servicemortalityneurosensorynovelphysical conditioningprognostic modelprognosticationprospectiverepositoryresiliencerisk stratificationtool
中文摘要
该项目的主要目标是通过集成和
以新颖的方式分析它们,以回答与轻度药物长期疗效相关的关键问题
随着时间的推移,退伍军人的创伤性脑损伤(MTBI)。尽管先前的研究发现,适度的
而严重的颅脑损伤与各种不良的临床结局有关,mTBI的影响是
不太为人所知。我们建议在过去几年工作的基础上,在慢性
神经创伤联盟的影响(CENC-流行病学研究),我们在其中组建了一个
近200万名退伍军人(包括所有患有脑外伤的退伍军人)的非常大或“巨型”数据存储库
诊断),包括多个不同的国家综合数据库。我们非常好
准备利用这一国家资源,继续最大限度地研究患有mTBI的退伍军人。
具体地说,我们现在拥有前所未有的能力,能够前瞻性地跟踪这些退伍军人
嵌入退伍军人管理局国家保健系统,我们可以调查过程和结果
TBI的。我们建议通过四个互补的方法来研究mTBI及其长期结果
边缘的三个目标下的具体目标。在目标1目标1中,我们建议维持,
扩充和改进我们当前的存储库,包括创建和改进相关的新变量
使用TBI。在目标2目标1中,我们将确定精神疾病风险和恢复力最高的亚群
MTBI后的健康和神经生成结果,包括极早发病的痴呆。在目标2中
目的2我们建议检查和阐明mTBI和mTBI之间的复杂联系。
合并症,如药物滥用、创伤后应激障碍等。在目标3目标1中,我们将制定预后
模型,以确定哪些退伍军人在mTBI后下降或维持/改善。我们的总体目标是
调查mTBI如何与其他共病,特别是精神健康因素交织在一起,以及
这些其他因素可能是如何协同或相加的,mTBI的远程不良后果是如何演变的
随着时间的推移,以及是什么预测了这种演变。此外,我们将把我们的发现转化为
将指导临床医生和研究人员更好地护理和预防mTBI的预后模型
以及相关的结果。
英文摘要
The primary objective of this project is to utilize a variety of existing data sources by integrating and
analyzing them in novel ways to answer key questions related to the long-term effects of mild
traumatic brain injury (mTBI) in veterans over time. Although prior studies have found that moderate
and severe TBI are associated with a variety of adverse clinical outcomes, the effects of mTBI are
less well understood. We propose to build on our past several years of work within The Chronic
Effects of Neurotrauma Consortium (CENC - Epidemiology Study) in which we have assembled a
very large or “mega” data repository of nearly 2 million veterans (including all veterans with a TBI
diagnosis) that comprises multiple different national synthesized databases. We are extremely well
positioned to capitalize on this national resource to continue to maximally study veterans with mTBI.
Specifically, we now have the unprecedented ability to follow these veterans prospectively as they are
embedded within the VA national care system and we can investigate both the course and outcomes
of TBI. We propose to investigate mTBI and its long-term outcomes through four complementary
Specific Aims under the three Objectives of LIMBIC. In Objective 1 Aim 1 we propose to maintain,
augment, and refine our current repository, including creating and refining new variables associated
with TBI. In Objective 2 Aim 1 we will identify subgroups at the greatest risk and resilience for mental
health and neurogenerative outcomes after mTBI, including very-early onset dementia. In Objective 2
Aim 2 we propose to examine and elucidate the complex associations between mTBI and
comorbidities such as substance abuse, PTSD, etc. In Objective 3 Aim 1 we will develop prognostic
models to determine which veterans decline versus sustain/improve after mTBI. Our overall goal is to
investigate how mTBI is interwoven with other comorbidities, especially mental health factors, and
how these other factors may be synergistic or additive, how mTBI remote adverse outcomes evolve
over time and what predicts this evolution. Furthermore, we will translate our findings to develop
prognostic models that will guide clinician and researchers toward better care and prevention of mTBI
and associated outcomes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Population Based Research for Alzheimer's Innovation (POP BRAIN)
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批准号:10415151
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项目类别:
-
资助金额:$94.53万
-
财政年份:2021
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负责人:Kristine Yaffe
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依托单位:
Population Based Research for Alzheimer's Innovation (POP BRAIN)
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批准号:10653866
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项目类别:
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资助金额:$94.53万
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财政年份:2021
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负责人:Kristine Yaffe
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依托单位:
Population Based Research for Alzheimer's Innovation (POP BRAIN)
-
批准号:10199565
-
项目类别:
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资助金额:$94.53万
-
财政年份:2021
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负责人:Kristine Yaffe
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依托单位:
VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Epidemiology Study
-
批准号:10426048
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Kristine Yaffe
-
依托单位:
Research Education Component
-
批准号:10647914
-
项目类别:
-
资助金额:$24.49万
-
财政年份:2019
-
负责人:Kristine Yaffe
-
依托单位:
Research Education Component
-
批准号:10431787
-
项目类别:
-
资助金额:$27.48万
-
财政年份:2019
-
负责人:Kristine Yaffe
-
依托单位:
Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment
-
批准号:9217270
-
项目类别:
-
资助金额:$194.85万
-
财政年份:2017
-
负责人:Kristine Yaffe
-
依托单位:
Chronic Effects of Neurotrauma Consortium (CENC) Epidemiology Study
-
批准号:9278103
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2015
-
负责人:Kristine Yaffe
-
依托单位:
Chronic Effects of Neurotrauma Consortium (CENC) Epidemiology Study
-
批准号:8997995
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2015
-
负责人:Kristine Yaffe
-
依托单位:
Long Term Depressive Symptom Course & Adverse Health Outcomes among Older Women
-
批准号:8037713
-
项目类别:
-
资助金额:$33.45万
-
财政年份:2010
-
负责人:Kristine Yaffe
-
依托单位:
Long Term Depressive Symptom Course & Adverse Health Outcomes among Older Women
-
批准号:8230682
-
项目类别:
-
资助金额:$33.1万
-
财政年份:2010
-
负责人:Kristine Yaffe
-
依托单位:
Long Term Depressive Symptom Course & Adverse Health Outcomes among Older Women
-
批准号:7883873
-
项目类别:
-
资助金额:$35.42万
-
财政年份:2010
-
负责人:Kristine Yaffe
-
依托单位:
DATA MANAGEMENT AND STATISTICAL CORE
-
批准号:7624798
-
项目类别:
-
资助金额:$13.73万
-
财政年份:2009
-
负责人:Kristine Yaffe
-
依托单位:
Predictors & Outcomes of Cognitive Trajectories in the Oldest Old
-
批准号:7499633
-
项目类别:
-
资助金额:$13.6万
-
财政年份:2007
-
负责人:Kristine Yaffe
-
依托单位:
Predictors of cognitive aging across the lifecourse
-
批准号:8509550
-
项目类别:
-
资助金额:$15.92万
-
财政年份:2007
-
负责人:Kristine Yaffe
-
依托单位:
Predictors & Outcomes of Cognitive Trajectories in the Oldest Old
-
批准号:7355843
-
项目类别:
-
资助金额:$13.36万
-
财政年份:2007
-
负责人:Kristine Yaffe
-
依托单位:
Predictors & Outcomes of Cognitive Trajectories in the Oldest Old
-
批准号:8113207
-
项目类别:
-
资助金额:$14.36万
-
财政年份:2007
-
负责人:Kristine Yaffe
-
依托单位:
Predictors & Outcomes of Cognitive Trajectories in the Oldest Old
-
批准号:7675216
-
项目类别:
-
资助金额:$13.84万
-
财政年份:2007
-
负责人:Kristine Yaffe
-
依托单位:
Cognitive Decline in Chronic Renal Insufficiency
-
批准号:6984301
-
项目类别:
-
资助金额:$50.68万
-
财政年份:2005
-
负责人:Kristine Yaffe
-
依托单位:
Cognitive Decline in Chronic Renal Insufficiency
-
批准号:7286385
-
项目类别:
-
资助金额:$47.0万
-
财政年份:2005
-
负责人:Kristine Yaffe
-
依托单位:
海外基金