VERMONT INBRE: BIOINFORMATICS CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 佛蒙特州遗传学网络生物信息学核心(BC)亮点 对于BC的三个目标，我们重印目标，然后总结要点。 目标1提供生物信息学服务，使研究人员在研究资金方面更具竞争力。服务包括实验设计以及数据管理和分析。这些服务将包括支持涉及寡核苷酸微阵列、LC-MS和蛋白质结构/功能的实验计划。更广泛地说，BC支持定制数据库的开发。 生物信息学核心正在帮助发展蛋白质组学设施的工作流程和能力。我们正在使用非常成功的微阵列设施作为最佳做法的指南。一台用于蛋白质组学处理的专用服务器已经集成到佛蒙特州高级计算中心集群中。这将使蛋白质组学处理能够根据需要进行扩展。我们正在与大学在这一领域的其他努力一起制定一项长期后备计划。 为了辅助蛋白质组学工作流程，已经实现了在线咨询系统。该系统允许研究人员在研究开始之前与蛋白质组学设施工作人员和生物信息学核心主管进行初步咨询。与微阵列设施一起开发了一个在线样品提交和跟踪系统。 生物信息学核心正在招聘一个额外的微阵列分析职位。微阵列设施的成功吸引了大量用户，需要更多的人员。 生物信息学核心为密歇根州立大学和合作伙伴大学内的许多研究项目提供咨询。 目标2向文凭院校(BPI)提供实验室/讲座单元。 VGN外联协调员Janet Murray博士继续开发和交付她的生物信息学和微阵列模块。为了协助管理这些模块，生物信息学核心为外联方案提供了一个新的内容管理系统。 目标3支持发展电子网络的行政基础设施。 生物信息学核心开发了一个区域核心设施数据库和在线应用程序。该应用程序维护东北地区核心设施的后端关系数据库。前端应用程序允许以各种方式进行搜索和过滤。目前对139个核心设施进行了跟踪。 VGN开发了一个佛蒙特州科学和技术专家的邮寄名单，称为Eris项目。ERIS已经存在了几年。在过去的一年里，它被用来在全州范围内发布39项公告。 作为这个邮件列表的扩展，生物信息学核心开发了一个网络网站，旨在促进佛蒙特州科学家和工程师之间的合作。佛蒙特州科学、工程和环境网络vSEEN.org允许用户发布他们的专业知识和兴趣的简介，以及关于他们工作的文章。这些信息可以通过简单的关键字进行搜索。私人联系是通过网站进行的，不会泄露任何一方的电子邮件地址。可以使用各种工具来帮助交互。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vermont Genetics Network Bioinformatics Core (BC) Highlights For each of the three BC Aims we reprint the aim and then summarize highlights. AIM 1 Provide bioinformatics services that make investigators more competitive for research funding. Services include experimental design as well as data management and analysis. These services will include support for experimental programs involving oligonucleotide microarrays, LC-Mass spectrometry, and protein structure/function. More generally, the BC supports development of custom databases. The Bioinformatics Core is helping to develop the workflow and capacity of the Proteomics Facility. We are using the highly successful Microarray Facility as a guide for best practices. A dedicated server for proteomics processing has been integrated into the Vermont Advanced Computing Center cluster. This will enable proteomics processing to scale as the need arises. We are in the process of developing a long term backup plan in conjunction with other University efforts in this area. To aid in the proteomics workflow on online consultation system has been implemented. This system allows research to sign themselves up for an initial consultation with the Proteomics Facility staff and the Bioinformatics Core director before research begins. An online sample submission and tracking system has been developed in conjunction with the Microarray Facility. The Bioinformatics Core is in the process of hiring for an additional microarray analysis position. The success of the Microarray Facility has attracted an abundance of users, requiring additional personnel. The Bioinformatics Core has provided consultation on numerous research projects within UVM and at partner colleges. AIM 2 Provide laboratory/lecture modules to Baccalaureate Institutions (BPI). Dr. Janet Murray, VGN Outreach coordinator, continues development and delivery of her Bioinformatics and Microarray modules. To aid the management of these modules the Bioinformatics Core provided a new content management system for the Outreach Program. AIM 3 Support the development of administrative infrastructure for electronic networks. The Bioinformatics Core has developed a Regional Core Facilities database and online application. This application maintains a backend relational database of core facilities in the northeast. A front end application allows searching and filtering in various ways. Currently 139 core facilities are tracked. The VGN developed a mailing list of Vermont Experts in Science and Technology, called the ERIS Project. ERIS has been in place for several years. It was used to make 39 statewide announcements during the past year. As an expansion of this mailing list the Bioinformatics Core has developed a networking website aimed at fostering collaboration among scientists and engineers in the state of Vermont. The Vermont Science, Engineering and Environment Network, vSEEN.org, allows user to publish a profile of their expertise and interests, and articles about their work. This information can be searched by simple keyword. Private contact is made through the website without divulging the email addresses of either party. A variety of tools to aid interaction are available.