THE ROLE OF C/EBPS IN ALZHEIMER'S DISEASE INFLAMMATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 博士Strohmeyer目前的研究兴趣是研究一个转录因子家族，该家族在调节阿尔茨海默病（AD）的几个细胞程序中起着核心作用。这个家族被称为CCAAT/增强子结合蛋白（C/EBP），有六个成员。Strohmeyer博士目前正专注于研究C/EBP在调节大脑小胶质细胞中炎症基因表达中的作用。已知小胶质细胞在脑炎症期间表达C/EBP，并且预期在这些细胞中调节该过程。Strohmeyer博士的研究目标是证明这是事实，并确定淀粉样蛋白B（AD的经典标志）是否诱导小胶质细胞中C/EBP的激活。通过进行进一步了解这些过程的研究，我们可能会获得新的见解，这些见解可能被证明对阿尔茨海默氏症和其他具有炎症成分的神经退行性疾病有治疗意义。 博士Strohmeyer的研究目前包括以下四个详细目标： ¿ 表征人脑组织和小胶质细胞系培养物中每种C/EBP同种型的表达模式。 ¿ 评估C/EBP在调节小胶质细胞系培养物中细胞因子、趋化因子、补体、iNOS和其他炎性基因表达中的功能。 ¿ 评估C/EBP在炎症刺激和B淀粉样蛋白诱导的小胶质细胞活化和分化中的作用。 ¿ 确定C/EBP是否可以通过抗炎药如非甾体抗炎药（NSAID）（即布洛芬）、统称为他汀类的降胆固醇药物和天然化合物如植物来源的多酚调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Strohmeyer's current research interests are in studying a transcription factor family that plays a central role in regulating several cellular programs of interest in Alzheimer's disease (AD). This family is known as the CCAAT/Enhancer Binding Proteins (C/EBPs) and has six members. Dr. Strohmeyer is currently focusing on studying the role of C/EBPs in regulating the expression of inflammatory genes in microglia cells in the brain. Microglia are known to express C/EBPs during brain inflammation and are expected to regulate this process in these cells. Dr. Strohmeyer's research objective is to show this to be the case and to determine whether amyloid b, a classical hallmark of AD, induces the activation of C/EBPs in microglia. By conducting studies that further our understanding of these processes, we may obtain novel insights that might prove to be therapeutically useful in Alzheimer's and other neurodegenerative diseases having an inflammatory component. Dr. Strohmeyer's research currently encompasses the following four detailed objectives: ¿ Characterizing the expression pattern of each C/EBP isoform in human brain tissue and in microglia cell line cultures. ¿ Assessing the functionality of C/EBPs in modulating the expression of cytokine, chemokine, complement, iNOS, and other inflammatory genes in microglia cell line cultures. ¿ Assessing the role of C/EBPs in microglial cell activation and differentiation in response to inflammatory stimuli and b amyloid protein. ¿ Determining whether C/EBPs may be modulated by anti-inflammatory drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. ibuprofen), cholesterol-lowering drugs collectively known as statins, and natural compounds such as plant-derived polyphenols.