Project 2 - Improving HIV prevention among postpartum women in Lilongwe, Malawi: the postpartum prevention package [Parent Title: PREVENTING INFANT INFECTIONS WITH IMPLEMENTATION SCIENCE IN MALAWI]

项目 2 - 改善马拉维利隆圭产后妇女的艾滋病毒预防：产后预防一揽子计划[父标题：在马拉维通过实施科学预防婴儿感染]

• 批准号: 10701196
• 负责人: Sarah E. Rutstein
• 金额: $ 20.31万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701196
• 关键词: AIDS prevention; Abstinence; Address; Adherence; Africa South of the Sahara; Appointment; Behavioral; Biological; Breast Feeding; Caring; Childhood; Clinic; Cluster randomized trial; Communities; Cost Effectiveness Analysis; Counseling; Cross-Sectional Studies; Data; Diagnostic Reagent Kits; Dose; Eligibility Determination; Female genitalia; Formulation; Goals; Guidelines; HIV; HIV Infections; HIV Seronegativity; HIV risk; Health; Health care facility; Hormonal; Human immunodeficiency virus test; Hybrids; Immunization Programs; Improve Access; Incidence; Infant; Infection; Injectable; International; Intervention; Interview; Late pregnancy; Link; Malawi; Measures; Methods; Modeling; Mothers; Oral; Outcome; Parents; Partner Notification; Patient Self-Report; Patients; Perinatal transmission; Persons; Pharmacy facility; Physiological; Policies; Policy Maker; Postpartum Period; Postpartum Women; Pregnancy; Prevention; Prevention program; Proctor framework; Provider; Randomized; Recommendation; Research Personnel; Risk; Risk Assessment; Services; Sex Behavior; Site; Testing; Time; Training; Treatment outcome; Unsafe Sex; Vaccination; Vertical Disease Transmission; Visit; Woman; budget impact; cost; cost effective; effectiveness evaluation; effectiveness outcome; follow-up; high risk; implementation outcomes; implementation science; implementation strategy; implementation/effectiveness; improved; incremental cost; infant infection; intervention cost; male; microcosting; novel; pediatric human immunodeficiency virus infection; peer; perinatal HIV; post implementation; pre-exposure prophylaxis; pregnant; premature; prevent; primary outcome; programs; prospective; reproductive tract; scale up; screening; secondary outcome; self testing; seroconversion; service delivery; sex; standard of care; stem; synergism; theories; tool; transmission process; treatment arm; uptake

PROJECT SUMMARY Impressive progress has been made towards the ambitious goal of eliminating mother to child transmission (EMTCT) globally. In efficient EMTCT programs with high rates of ART uptake, an increasing proportion of new infant infections stem from incident maternal infections; in sub-Saharan Africa nearly one third of infant transmissions are linked to HIV infections that are acquired during pregnancy or breastfeeding. Driven by physiological shifts and behavioral changes, including resumption of condomless intercourse, the postpartum period is a particularly high-risk period for HIV acquisition. In Malawi, one-third of all new pediatric HIV infections are attributed to women who acquired HIV infection while breastfeeding. Improved postpartum HIV prevention is needed to prevent pediatric infections. One promising HIV prevention opportunity is HIV pre- exposure prophylaxis (PrEP). Taken as prescribed, daily oral PrEP effectively prevents HIV and is safe during breastfeeding. Unfortunately, uptake of and adequate adherence to PrEP among postpartum women in sub- Saharan Africa, including in Malawi, has been poor. Newer long-acting PrEP formulations, including injectable PrEP, is a promising and potentially paradigm shifting advance for HIV prevention, offering more discrete and convenient dosing. However, to maximize the prevention potential of PrEP (oral, injectable, or other), programs must address shortfalls across the prevention cascade –increasing rates of postpartum HIV testing, reducing barriers to PrEP initiation, and improving retention in PrEP care by tracing defaulters. This study will test an intervention that mobilizes an integrated, task-shifting strategy to improve effective PrEP use among postpartum women in Malawi. Leveraging maternal attendance at early infant vaccination visits, the integrated intervention deploys effective strategies to increase HIV testing, promote partner engagement, enhance access to oral or injectable PrEP, and retain women in PrEP care. The intervention uses task-shifting to integrate HIV testing and PrEP services into infant vaccination visits, and builds on the highly-effective community-facility linkage model “peers”, expanding tracing to include PrEP defaulters. In Aim 1, investigators evaluate the effectiveness the integrated “postpartum prevention package” intervention, examining primary outcome of PrEP persistence at 12 months among breastfeeding women. Secondary outcomes include PrEP uptake, PrEP adherence, and seroconversions. Aim 2 focuses on implementation outcomes, examining fidelity to and acceptability of the integrated intervention among postpartum women, a subset of their male partners, clinic providers, and policymakers. In Aim 3 investigators conduct a cost-effectiveness analysis using effectiveness outcomes and prospectively collected costs, modelling cost per new PrEP initiation and per person retained on PrEP. A budget impact analysis identifies drivers of cost, informing Ministry of Health staffing and implementation. If successful at increasing effective PrEP use and cost-effective, this intervention can be scaled to other clinics in Malawi and across sub-Saharan Africa.

项目总结