EXERCISE TRAINING REDUCES CENTRAL ADIPOSITY AND IMPROVES METABOLIC INDICES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 据报道，经高效抗逆转录病毒疗法(HAART)治疗的HIV患者体内脂肪再分配(BFR)和代谢紊乱与心血管疾病和糖尿病风险增加有关。随着HAART变得更容易获得，一个挑战是如何管理艾滋病毒和HAART代谢综合征。尽管运动在HIV血清阴性人群中有代谢和身体成分紊乱的风险，但很少有试验研究运动对HAART治疗的患有BFR的HIV患者的影响。我们进行了一项为期6个月的随机对照试验，以测试运动训练是否改善了患有BFR的HAART治疗的HIV患者的代谢和身体组成参数，并增强了他们的心肺功能。6个月后，运动组腰围(7.13±4.4 cm，p&lt；0.0001)、腰臀比(0.10±0.1，p&lt；0.0001)、皮褶厚度(6.15±8.2 mm，p&lt；0.0001)和体脂百分比(1.5±3.3，p&lt；0.0001)显著下降。所有组的臀围均无变化。运动训练显著降低空腹总胆固醇[-0.03±1.11 mm，p&lt；0.05]甘油三酯[-0.22？0.48 mm，p&lt；0.05]和血糖水平[-0.21？0.71 mM，p&lt；0.05](p&lt；0.0001)。运动训练后高密度脂蛋白、低密度脂蛋白和HOMA值无明显变化。有趣的是，在非运动组中，艾滋病毒感染者的空腹血糖水平显著升高，而艾滋病毒血清阴性对照组则没有(p&lt；0.001)。运动组预计VO2峰值较其他组升高更明显(4.7ml/kg/min，p&lt；0.0001)。运动训练积极地调节了身体成分和代谢特征，并改善了心肺健康。这些发现为改善心血管和糖尿病状况提供了证据，有助于降低发病率和死亡率。我们的发现支持了运动训练对接受HAART治疗的艾滋病毒患者的好处，主要是在资源有限的撒哈拉以南地区和其他国家，那里的艾滋病毒治疗正在改善，但管理艾滋病毒和HAART相关疾病的资源很少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Body fat redistribution (BFR) and metabolic disorders, reported in highly active antiretroviral therapy (HAART) -treated HIV patients have been associated with increased cardiovascular disease and diabetes risks. As HAART becomes more accessible, one challenge is how to manage HIV- and HAART-metabolic syndromes. Despite the benefits of exercise in HIV seronegative population at risk of metabolic and body composition disorders, few trials have studied the effects of exercise in HAART-treated HIV patients with BFR. We conducted a 6-month, randomized controlled trial to test whether exercise training improves metabolic and body composition parameters, and enhances cardiorespiratory fitness in HAART-treated HIV patients with BFR. At 6 months, the exercise group experienced a significant decrease in waist circumference (7.13 ¿ 4.4 cm, p<0.0001), WHR (0.10 ¿ 0.1, p<0.0001), sum skinfold thickness (6.15 ¿ 8.2 mm, p<0.0001) and % BFM (1.5 ¿ 3.3, p<0.0001). Hip circumference was unchanged in all groups. Exercise training significantly reduced fasting total cholesterol [-0.03 ¿1.11 mM, p<0.05] triglycerides [-0.22 ¿0.48 mM, p<0.05] and glucose levels [(-0.21¿0.71mM, p<0.05] (p<0.0001). HDL-, LDL-cholesterol and HOMA values were unchanged after exercise training. Interestingly, HIV-infected subjects in non-exercising groups exhibited significant increases in fasting glucose levels, whereas HIV seronegative controls did not (p<0.001). Predicted VO2 peak increased more in the exercise group than in all other groups (4.7¿3.9 ml/kg/min, p<0.0001). Exercise training positively modulated body composition and metabolic profiles, and improved cardiorespiratory fitness. The findings provide evidence for improved cardiovascular and diabetic profile, contributing to decreased morbidity and mortality rates. Our findings underpin the benefits of exercise training in HAART-treated HIV patients, mainly in resource-limited sub-Saharan and other countries, where HIV treatment is improving but with minimal resources to manage HIV- and HAART-associated disorders.