EXERCISE TRAINING REDUCES CENTRAL ADIPOSITY AND IMPROVES METABOLIC INDICES

运动训练可减少中心性肥胖并改善代谢指数

• 批准号: 7721565
• 负责人: Eugene Mutimura
• 金额: $ 1.77万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721565
• 关键词: Body Composition; Body fat; Cardiovascular Diseases; Cardiovascular system; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Country; Disease; Exercise; Exhibits; Fasting; Funding; Glucose; Grant; HIV; High Density Lipoproteins; Highly Active Antiretroviral Therapy; Hip region structure; Institution; LDL Cholesterol Lipoproteins; Metabolic; Metabolic Diseases; Metabolic syndrome; Morbidity - disease rate; Obesity; Patients; Populations at Risk; Randomized Controlled Trials; Rate; Reporting; Research; Research Personnel; Resources; Skinfold Thickness; Source; Sum; Testing; Training; Triglycerides; United States National Institutes of Health; diabetes risk; diabetic; experience; fitness; improved; indexing; mortality; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Body fat redistribution (BFR) and metabolic disorders, reported in highly active antiretroviral therapy (HAART) -treated HIV patients have been associated with increased cardiovascular disease and diabetes risks. As HAART becomes more accessible, one challenge is how to manage HIV- and HAART-metabolic syndromes. Despite the benefits of exercise in HIV seronegative population at risk of metabolic and body composition disorders, few trials have studied the effects of exercise in HAART-treated HIV patients with BFR. We conducted a 6-month, randomized controlled trial to test whether exercise training improves metabolic and body composition parameters, and enhances cardiorespiratory fitness in HAART-treated HIV patients with BFR. At 6 months, the exercise group experienced a significant decrease in waist circumference (7.13 ¿ 4.4 cm, p<0.0001), WHR (0.10 ¿ 0.1, p<0.0001), sum skinfold thickness (6.15 ¿ 8.2 mm, p<0.0001) and % BFM (1.5 ¿ 3.3, p<0.0001). Hip circumference was unchanged in all groups. Exercise training significantly reduced fasting total cholesterol [-0.03 ¿1.11 mM, p<0.05] triglycerides [-0.22 ¿0.48 mM, p<0.05] and glucose levels [(-0.21¿0.71mM, p<0.05] (p<0.0001). HDL-, LDL-cholesterol and HOMA values were unchanged after exercise training. Interestingly, HIV-infected subjects in non-exercising groups exhibited significant increases in fasting glucose levels, whereas HIV seronegative controls did not (p<0.001). Predicted VO2 peak increased more in the exercise group than in all other groups (4.7¿3.9 ml/kg/min, p<0.0001). Exercise training positively modulated body composition and metabolic profiles, and improved cardiorespiratory fitness. The findings provide evidence for improved cardiovascular and diabetic profile, contributing to decreased morbidity and mortality rates. Our findings underpin the benefits of exercise training in HAART-treated HIV patients, mainly in resource-limited sub-Saharan and other countries, where HIV treatment is improving but with minimal resources to manage HIV- and HAART-associated disorders.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 据报道，在接受高效抗逆转录病毒疗法（HAART）治疗的艾滋病毒患者中，体脂再分布（BFR）和代谢紊乱与心血管疾病和糖尿病风险增加有关。随着HAART变得越来越容易获得，一个挑战是如何管理HIV和HAART代谢综合征。尽管运动对有代谢和身体成分紊乱风险的HIV血清阴性人群有益，但很少有试验研究运动对HAART治疗的BFR HIV患者的影响。我们进行了一项为期6个月的随机对照试验，以测试运动训练是否能改善代谢和身体成分参数，并增强HAART治疗的BFR HIV患者的心肺适应性。 在6个月时，运动组的腰围显著减少（7.13 00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000.10 0.0001），皮褶厚度总和（6.15 0.0001）和% BFM（1.5 3.3，p<0.0001）。所有组中的臀围均无变化。运动训练显著降低了空腹总胆固醇[-0.03 <$1.11 mM，p<0.05]、甘油三酯[-0.22 <$0.48 mM，p<0.05]和葡萄糖水平[（-0.21 <$0.71 mM，p<0.05]（p<0.0001）。HDL-，LDL-胆固醇和HOMA值在运动训练后没有变化。有趣的是，非运动组的HIV感染者空腹血糖水平显著升高，而HIV血清阴性对照组则没有（p<0.001）。运动组的预测VO 2峰值比所有其他组增加更多（4.7 <$3.9 ml/kg/min，p<0.0001）。运动训练积极调节身体成分和代谢概况，并改善心肺功能。这些发现为改善心血管和糖尿病状况提供了证据，有助于降低发病率和死亡率。我们的研究结果支持HAART治疗的艾滋病患者运动训练的好处，主要是在资源有限的撒哈拉以南非洲和其他国家，艾滋病治疗正在改善，但管理艾滋病和HAART相关疾病的资源很少。